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Home >> Signaling Pathways >> Tyrosine Kinase >> EGFR

EGFR(表皮生长因子受体)

EGFR (epidermal growth factor receptor) is the cell-surface receptor of its specific ligands, including epidermal growth factor and TGFα (transforming growth factor α) and is a receptor tyrosine kinase.

Products for  EGFR

  1. Cat.No. 产品名称 Information
  2. GC18030 JNJ 28871063 hydrochloride JNJ 28871063 hydrochloride 是一种具有口服活性、高选择性和 ATP 竞争性的 pan-ErbB 激酶抑制剂，对 ErbB1、ErbB2 和 ErbB4 的 IC50 值分别为 22 nM、38 nM 和 21 nM。 JNJ 28871063 hydrochloride 抑制 EGFR 和 ErbB2 中功能重要的酪氨酸残基的磷酸化。 JNJ 28871063 hydrochloride 可穿过血脑屏障，在过度表达 EGFR 和 ErbB2 的人类肿瘤异种移植模型中具有抗肿瘤活性。
  3. GC15674 HDS 029 HDS 029 (compound 29) 是一种有效的酪氨酸激酶抑制剂，对 erbB1、erbB2、erbB4、EGF、HER 的 IC50 分别为 0.3、1.1、0.5、2.5、24 nM。
  4. GC15925 PD 158780

    N4-(3-溴苯基)-N6-甲基-吡啶并[3,4-D]嘧啶-4,6-二胺

     An ErbB receptor family inhibitor
  5. GC10815 BIBU 1361 dihydrochloride

    N-(3-氯-4-氟苯基)-6-[4-[(二乙基氨基)甲基]-1-哌啶基]嘧啶并[5,4-D]嘧啶-4-胺

     EGFR inhibitor
  6. GC15927 GW 583340 dihydrochloride dual EGFR/ErbB2 tyrosine kinase inhibitor
  7. GC13168 AG 825

    酪氨酸磷酸化抑制剂AG825,Tyrphostin AG-825

     An inhibitor of Her2/Neu tyrosine kinase activity
  8. GC17489 AG 494

    Tyrphostin AG 494

     An inhibitor of EGF receptor kinase
  9. GC11744 AG 555

    Tyrphostin AG 555

     A tyrphostin EGFR inhibitor
  10. GC12233 AG 556

    (E)-Tyrphostin AG 556

     An EGFR inhibitor
  11. GC15038 Tyrphostin B44, (+) enantiomer

    酪氨酸磷酸化抑制剂AG835,Tyrphostin AG 835; Tyrphostin B 50

     Tyrphostin B44, (+) enantiomer (Tyrphostin AG 835) (Compound B50) 是一种具有抗肿瘤活性的 EGRF 抑制剂。
  12. GC12977 Tyrphostin B44, (-) enantiomer EGFR-kinase inhibitor
  13. GC12069 Methyl 2,5-dihydroxycinnamate

    2,5-二羟基肉桂酸甲酯

     An EGFR tyrosine kinase inhibitor
  14. GC14494 AG 99

    酪氨酸磷酸化抑制剂A46,(E)-Tyrphostin 46; (E)-Tyrphostin AG 99

     An inhibitor of EGF receptor kinase
  15. GC14136 BMS 599626 dihydrochloride EGFR and ErbB2 inhibitor,potent and selective
  16. GC16021 Lavendustin A

    薰草菌素; RG-14355

     A selective inhibitor of EGF receptor-associated tyrosine kinase
  17. GC15271 Tyrphostin AG 879

    AG 879

     A non-specific tyrphostin ErbB2 inhibitor
  18. GC10250 Mubritinib (TAK 165)

    木利替尼; TAK-165

     Mubritinib (TAK 165)是一种有效的选择性 HER2/ErbB2 抑制剂，其IC50为6nM。
  19. GC13854 AG-490 (Tyrphostin B42)

    酪氨酸磷酸化抑制剂AG490

     AG-490 (Tyrphostin B42)是EGFR抑制剂,IC50为0.1 µM, AG-490对JAK2也有抑制作用。
  20. GC16698 AZD-9291 mesylate

    奥希替尼甲磺酸盐; AZD-9291 mesylate; Mereletinib mesylate

    An inhibitor of mutant EGFR
  21. GC16308 AZD-9291

    奥希替尼; AZD-9291; Mereletinib

    An inhibitor of mutant EGFR
  22. GC17982 Icotinib

    埃克替尼; BPI-2009

     An EGFR inhibitor
  23. GC11126 Mutant EGFR inhibitor

    N-[5-[[5-氯-4-(1H-吲哚-3-基)-2-嘧啶基]氨基]-2-[[2-(二甲基氨基)乙基]甲基氨基]-4-甲氧基苯基]-2-丙烯酰胺

     Mutant EGFR inhibitor 是从专利WO 2013014448 A1中提取的一种有效的选择性突变EGFR抑制剂；抑制 EGFRL858R、EGFRExon 19 缺失和 EGFRT790M。
  24. GC15669 AST-1306 TsOH

    艾力替尼; AST-1306 (TsOH)

     An irreversible inhibitor of EGFR, HER2, and HER4
  25. GC17530 OSI-420

    OSI-420; CP-373420 hydrochloride

     OSI-420 (OSI-420) 是厄洛替尼的活性代谢物。厄洛替尼是一种有效的 EGFR 酪氨酸激酶抑制剂。
  26. GC11264 CNX-2006 An irreversible inhibitor of mutant EGFRs
  27. GC16000 WHI-P180

    3-[(6,7-二甲氧基-4-喹唑啉基)氨基]苯酚,Janex 3

     A multi-kinase inhibitor
  28. GC11172 TAK-285 A dual inhibitor of EGFR and HER2
  29. GC13761 AZD8931 (Sapitinib)

    沙普替尼; AZD-8931

     A reversible inhibitor of ErbB1/EGFR, ErbB2/HER2, and ErbB3/HER3
  30. GC11691 AST-1306

    AST1306; AST 1306

     An irreversible inhibitor of EGFR, HER2, and HER4
  31. GC12478 ARRY-380

    ARRY380; ARRY 380

     An inhibitor of EGFR
  32. GC12249 Varlitinib (ARRY334543)

    泛EGFR小分子抑制剂(VARLITINIB),ARRY-334543; ARRY 334543

     An inhibitor of EGFR and HER2
  33. GC17226 AG-1478

    Tyrphostin AG-1478; AG 1478; NSC 693255; AG1478

     An inhibitor of EGF receptor kinase
  34. GC10362 Neratinib (HKI-272)

    来那替尼; HKI-272

     A dual inhibitor of EGFR and HER2
  35. GC10225 Dacomitinib (PF299804, PF299)

    达克替尼; PF-00299804; PF-299804

     A pan-ErbB receptor tyrosine kinase inhibitor
  36. GC17283 AP26113

    Brigatinib analog

     A potent ALK inhibitor
  37. GC10944 Butein

    紫铆因; 2’,3,4,4’-tetrahydroxy Chalcone

     A plant polyphenol
  38. GC17647 AG-18

    酪氨酸磷酸化抑制剂23,Tyrphostin A23; RG-50810; AG 18

     An inhibitor of EGF receptor kinase
  39. GC11015 PD168393 An irreversible EGFR kinase inhibitor
  40. GC11892 AEE788 (NVP-AEE788)

    6-[4-[(4-乙基-1-哌嗪)甲基]苯基]-N-[(1R)-1-苯基乙基]-7H-吡咯并[2,3-D]嘧啶-4-胺,NVP-AEE 788

     An inhibitor of EGFR and VEGFR tyrosine kinases
  41. GC12910 Canertinib (CI-1033)

    卡奈替尼; CI-1033; PD-183805

     Canertinib (CI-1033) (CI-1033;PD-183805) 是一种有效且不可逆的 EGFR 抑制剂；抑制细胞 EGFR 和 ErbB2 自磷酸化，IC50 为 7.4 和 9 nM。
  42. GC13257 AC480 (BMS-599626)

    AC480

     A dual inhibitor of EGFR and HER2
  43. GC11250 WZ8040 An inhibitor of mutant EGFR
  44. GC17473 Pelitinib (EKB-569)

    培利替尼; EKB-569; WAY-EKB 569

     An EGFR receptor tyrosine kinase inhibitor
  45. GC13091 CP-724714

    2-甲氧基-N-[(2E)-3-[4-[[3-甲基-4-[(6-甲基-3-吡啶基)氧基]苯基]氨基]-6-喹唑啉基]-2-丙烯-1-基]乙酰胺

     A selective HER2/ErbB2 tyrosine kinase inhibitor
  46. GC15494 WZ4002 A potent inhibitor of EGFR-T790M kinase activity
  47. GC14102 Genistein

    染料木素; NPI 031L

     染料木黄酮是一种异黄酮，属于类黄酮化合物，存在于多种植物中。
  48. GC13296 Afatinib(BIBW2992)

    阿法替尼

     A selective dual inhibitor of EGFR/HER2
  49. GC15600 Erlotinib Hydrochloride

    盐酸埃罗替尼; CP-358774 hydrochloride; NSC 718781 hydrochloride; OSI-774 hydrochloride

     An EGFR tyrosine kinase inhibitor
  50. GC16737 Gefitinib (ZD1839)

    吉非替尼; ZD1839

    吉非替尼(Gefitinib, ZD1839)是一种强效的表皮生长因子受体酪氨酸激酶抑制剂(EGFR-TKI),IC50为0.033 µM,能选择性抑制表皮生长因子刺激的肿瘤细胞生长,IC50为0.054 µM,并能阻断表皮生长因子刺激的表皮生长因子受体(EGFR)在肿瘤细胞中的自身磷酸化。
  51. GC13608 Lapatinib

    拉帕替尼; GW572016; GW2016

     A dual inhibitor of EGFR and ErbB2

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