FLT3(FMS样酪氨酸激酶3)

FLT3 (FMS-like tyrosine kinase 3) is a cytokine receptor which belongs to the receptor tyrosine kinase class III and plays a role in cell survival, proliferation, and differentiation.

Products for FLT3

Cat.No. 产品名称 Information
GC14582 SU5614
(3Z)-5-氯-3-[(3,5-二甲基-1H-吡咯-2-基)亚甲基]-1,3-二氢-2H-吲哚-2-酮
A multi-kinase inhibitor
GC17959 AZD2932 A multi-kinase inhibitor
GC16604 Altiratinib
DCC-2701
A multiple kinase inhibitor
GC15556 UNC2025
反式-4-[2-(丁基氨基)-5-[4-[(4-甲基-1-哌嗪基)甲基]苯基]-7H-吡咯并[2,3-D]嘧啶-7-基]-环己醇
An orally bioavailable inhibitor of Mer and Flt3
GC12178 G-749
G-749
An FLT3 kinase inhibitor
GC11205 5'-Fluoroindirubinoxime
5'-FIO
An inhibitor of FLT3 kinase
GC14007 DCC-2036 (Rebastinib)
N-[3-叔丁基-1-(喹啉-6-基)-1H-吡唑-5-基]-N'-[2-氟-4-[(2-(甲基氨基甲酰基)吡啶-4-基)氧]苯基]脲,DCC-2036
An orally bioavailable tyrosine kinase inhibitor
GC15254 Tandutinib (MLN518)
坦度替尼; MLN518; CT53518
An antagonist of PDGFRβ, FLT3, and c-Kit
GC14974 AMG 925 A dual inhibitor of FLT3 and Cdk4
GC15739 CHIR-124
4-[((3S)-1-氮杂双环[2,2,2]辛-3-基)氨基]-3-(1H-苯并咪唑-2-基)-6-氯喹啉-2(1H)-酮
A selective Chk1 inhibitor
GC14906 Crenolanib (CP-868596)
[1-[2-[5-(3-甲基氧杂环丁烷-3-基甲氧基)苯并咪唑-1-基]喹啉-8-基]哌啶-4-基]胺,CP-868596;CP 868596;CP868596
An inhibitor of PDGFRα/β and FLT3
GC12058 TCS 359
Fms-like Tyrosine Kinase Inhibitor, TCS 359
A cell-permeable FLT3 inhibitor
GC17615 Quizartinib (AC220)
奎扎替尼; AC220
An inhibitor of FLT3
GC14396 Ponatinib (AP24534)
普纳替尼; AP24534
An inhibitor of native and mutant Bcr-Abl
GC15779 Cabozantinib (XL184, BMS-907351)
卡博替尼; XL184; BMS-907351
Cabozantinib (XL184,BMS-907351) 是一种新型 MET 和 VEGFR2 抑制剂，可同时抑制转移、血管生成和肿瘤生长。
GC13547 Dovitinib (TKI-258, CHIR-258)
多韦替尼; CHIR-258; TKI258
A multi-kinase inhibitor
GC17958 Linifanib (ABT-869)
利尼伐尼,ABT-869; AL-39324
A dual VEGFR and PDGFR family kinase inhibitor
GC16499 Sorafenib Tosylate
甲苯磺酸索拉非尼; Bay 43-9006 Tosylate
A multi-kinase inhibitor
GC17033 Lestaurtinib
来他替尼; CEP-701; KT-5555
A potent JAK2 and PRK1 kinase inhibitor
GC15307 SU5416
司马沙尼; SU5416; Semaxanib
SU5416 是一种有效的小分子血管内皮生长因子受体 (VEGFR) 抑制剂。
GC11455 Silvestrol
(1R,2R,3S,3AR,8BS)-6-[[(2S,3R,6R)-6-[(1R)-1,2-二羟基乙基]-3-甲氧基-1,4-二氧己环-2-基]氧基]-2,3,3A,8B-四氢-1,8B-二羟基-8-甲氧基-3A-(4-甲氧基苯基)-3-苯基-1H-环戊烯并[B]苯并呋喃-2-羧酸甲酯,(-)-Silvestrol
Silvestrol 是一种真核翻译起始因子 4A (eIF4A) 抑制剂，从 Agave americana Linn 中分离出来。Silvestrol 诱导自噬和半胱天冬酶介导的细胞凋亡。
GC12064 SB1317
14-甲基-20-氧杂-5,7,14,27-四氮杂四环[19.3.1.1(2,6).1(8,12)]二十七碳-1(25),2,4,6(27),8,10,12(26),16,21,23-十烯,TG02;SB 1317;TG 02;SB-1317;TG-02
A multi-kinase inhibitor
GC11057 LY2801653
梅沙替尼,LY-2801653;LY 2801653
A MET kinase inhibitor
GC10914 AST 487
NVP-AST 487
A multi-kinase inhibitor
GC16391 Amuvatinib (MP-470, HPK 56)
N-(1,3-苯并二氧戊环-5-基甲基)-4-苯并呋喃并[3,2-D]嘧啶-4-基-1-哌嗪硫代甲酰胺,MP470,MP 470,HPK56
A multi-targeted RTK inhibitor
GC14592 KW 2449
[4-[2-(1H-吲唑-3-基)乙烯基]苯基]-1-哌嗪基甲酮
A multi-kinase inhibitor
GC10638 AT9283 A broad spectrum kinase inhibitor
GC16519 ENMD-2076
6-(4-甲基-1-哌嗪基)-N-(5-甲基-1H-吡唑-3-基)-2-[(1E)-2-苯乙烯基]-4-嘧啶胺
A multi-kinase inhibitor
GC12145 ENMD-2076 L-(+)-Tartaric acid ENMD-2076 L-(+)-Tartaric acid 是一种多靶点激酶抑制剂，对 Aurora A、Flt3、KDR/VEGFR2、Flt4/VEGFR3、FGFR1 的 IC50 为 1.86、14、58.2、15.9、92.7、70.8、56.4 nM , FGFR2, Src, PDGFRα, 分别。
GC13848 LY2784544
Gandotinib
Potent inhibitor of JAK2
GC10035 TG101209
N-(1,1-二甲基乙基)-3-[[5-甲基-2-[[4-(4-甲基-1-哌嗪基)苯基]氨基]-4-嘧啶基]氨基]苯磺酰胺,TG-101209
An inhibitor of JAK2, FLT3, RET, and JAK3
GC17369 Sorafenib
索拉非尼; Bay 43-9006
索拉非尼Sorafenib是Raf-1和B-Raf的多激酶抑制剂，IC50分别为6 nM和22 nM;Sorafenib对VEGFR-2 VEGFR-3 PDGFR-β Flt-3和c-KIT也有抑制作用，IC50值分别为90 nM、20 nM、57 nM、59 nM和68 nM;索拉非尼能诱导自噬细胞凋亡和激活铁死亡，并具有抗肿瘤活性。