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Home >> Signaling Pathways >> Tyrosine Kinase >> PDGFR

PDGFR(血小板衍生生长因子受体)

PDGFR (platelet-derived growth factor receptor) is a group of cell surface tyrosine kinase receptors for members of the PDGF (platelet-derived growth factor) family.

Products for  PDGFR

  1. Cat.No. 产品名称 Information
  2. GC32835 PP58

    PP58是吡啶[2,3-d]嘧啶化合物，抑制PDGFR，FGFR和Src家族活性的IC50值在纳摩尔级。
  3. GC32458 Trapidil (AR-12008)

    唑嘧胺; AR-12008

     An inhibitor of PDGF-induced activity and an antiplatelet agent
  4. GC19074 Avapritinib

    阿伐普替尼,BLU-285

     A dual inhibitor of KIT and PDGFRα mutant kinases
  5. GC18168 JI-101

    CGI1842

     An inhibitor of VEGFR2, PDGFRβ, and EphB4
  6. GC18167 AC710

    N-[4-[[[[5-(叔丁基)-3-异恶唑基]氨基]羰基]氨基]苯基]-5-[(1-乙基-2,2,6,6-四甲基-4-哌啶基)氧基]-2-吡啶甲酰胺

     A PDGFR family kinase inhibitor
  7. GC16235 AG-1295

    酪氨酸磷酸化抑制剂AG1295,NSC 380341,Tyrphostin AG-1295

     A selective inhibitor of PDGF receptor kinase
  8. GC11712 AG-370

    NSC 651712

     A selective inhibitor of PDGF receptor kinase.
  9. GC14544 JNJ-10198409

    3-氟-N-(6,7-二甲氧基-2,4-二氢茚并[1,2-C〕吡唑-3-基)苯基胺

     A potent PDGF tyrosine kinase inhibitor
  10. GC17959 AZD2932 A multi-kinase inhibitor
  11. GC12686 SU 16f

    SU16F

     A potent inhibitor of PDGFRβ
  12. GC17024 DMPQ dihydrochloride An potent inhibitor of PDGFRβ
  13. GC10314 Imatinib (STI571)

    伊马替尼; STI571; CGP-57148B

     伊马替尼 (STI571) (STI571) 是一种口服生物可利用的酪氨酸激酶抑制剂，可选择性抑制 BCR/ABL、v-Abl、PDGFR 和 c-kit 激酶活性。伊马替尼 (STI571) (STI571) 通过在 ATP 结合位点附近结合而起作用，将其锁定在封闭或自我抑制的构象中，从而半竞争性地抑制蛋白质的酶活性。伊马替尼 (STI571) 也是 SARS-CoV 和 MERS-CoV 的抑制剂。
  14. GC12980 CP-673451 A selective PDGFRα/β kinase inhibitor
  15. GC11003 PP121 A potent dual inhibitor of tyrosine and phosphoinositide kinases
  16. GC17651 Sunitinib

    舒尼替尼; SU 11248

     舒尼替尼Sunitinib（SU 11248）是一种具口服活性的多靶点受体酪氨酸激酶抑制剂，对血管内皮生长因子受体（VEGFR2）和血小板衍生生长因子受体（PDGFRβ）的IC50分别为80nM和2nM。
  17. GC15254 Tandutinib (MLN518)

    坦度替尼; MLN518; CT53518

     An antagonist of PDGFRβ, FLT3, and c-Kit
  18. GC10220 TAK-593 TAK-593 是一种有效的 VEGFR 和 PDGFR 家族抑制剂，对 VEGFR1、VEGFR2、VEGFR3、PDFGRα 和 PDFGRβ 的 IC50 分别为 3.2、0.95、1.1、4.3 和 13 nM。
  19. GC14676 Pacritinib (SB1518)

    帕克替尼

     An equipotent inhibitor of FLT3 and JAK2
  20. GC13914 Flumatinib mesylate

    甲磺酸氟马替尼; HHGV678 mesylate

     A Bcr-Abl inhibitor
  21. GC11763 Telatinib (BAY 57-9352)

    替拉替尼,BAY 579352;BAY 57 9352

     A multi-kinase inhibitor
  22. GC15739 CHIR-124

    4-[((3S)-1-氮杂双环[2,2,2]辛-3-基)氨基]-3-(1H-苯并咪唑-2-基)-6-氯喹啉-2(1H)-酮

     A selective Chk1 inhibitor
  23. GC16337 MK-2461 A c-MET inhibitor
  24. GC12216 Axitinib (AG 013736)

    阿昔替尼; AG-013736

     Axitinib (AG 013736)是一种具有口服活性的特异性血管内皮生长因子受体（VEGFR）抑制剂，主要靶向VEGFR-1、VEGFR-2和VEGFR-3，IC50值分别为 0.1nM、0.2nM和0.1-0.3nM。
  25. GC12730 Pazopanib Hydrochloride

    盐酸帕唑帕尼; GW786034 (Hydrochloride)

     A multi-kinase inhibitor
  26. GC14906 Crenolanib (CP-868596)

    [1-[2-[5-(3-甲基氧杂环丁烷-3-基甲氧基)苯并咪唑-1-基]喹啉-8-基]哌啶-4-基]胺,CP-868596;CP 868596;CP868596

     An inhibitor of PDGFRα/β and FLT3
  27. GC13045 Tyrphostin AG 1296

    AG1296

     An inhibitor of PDGF receptor kinase
  28. GC14396 Ponatinib (AP24534)

    普纳替尼; AP24534

     An inhibitor of native and mutant Bcr-Abl
  29. GC16732 TSU-68 (SU6668,Orantinib)

    SU6668; TSU-68

     An inhibitor of select receptor tyrosine kinases
  30. GC15454 Lenvatinib (E7080)

    仑伐替尼; E7080

     E7080，称为乐伐替尼，是一种口服多靶点酪氨酸激酶抑制剂，包括 VEGF、FGF 和 SCF 受体，已被证明可以提高放射性碘难治性甲状腺癌患者的生存率。
  31. GC16421 Cediranib (AZD217)

    西地尼布; AZD2171

     An inhibitor of VEGF receptor tyrosine kinases
  32. GC13547 Dovitinib (TKI-258, CHIR-258)

    多韦替尼; CHIR-258; TKI258

     A multi-kinase inhibitor
  33. GC11759 Imatinib Mesylate (STI571)

    甲磺酸伊马替尼; STI571 Mesylate; CGP-57148B Mesylate

     An inhibitor of c-Abl, Bcr-Abl, PDGFR, and c-Kit
  34. GC17958 Linifanib (ABT-869)

    利尼伐尼,ABT-869; AL-39324

     A dual VEGFR and PDGFR family kinase inhibitor
  35. GC13410 Masitinib (AB1010)

    马赛替尼; AB1010

     An inhibitor of c-Kit
  36. GC14683 Sunitinib malate

    苹果酸舒尼替尼,SU 11248,SU11248,SU-11248,Sunitinib

     A multi-kinase inhibitor
  37. GC11705 Nintedanib (BIBF 1120)

    尼达尼布,Vargatef

     A VEGFR, FGFR, and PDGFR inhibitor
  38. GC16499 Sorafenib Tosylate

    甲苯磺酸索拉非尼; Bay 43-9006 Tosylate

     A multi-kinase inhibitor
  39. GC12776 SKLB610

    SKLB610; SKLB 610; SKLB-610

     An inhibitor of VEGFR2
  40. GC10111 Regorafenib

    瑞戈非尼; BAY 73-4506

     A multi-kinase inhibitor
  41. GC12656 ZM323881

    ZM 323881;ZM-323881

     A potent and selective VEGFR2 inhibitor
  42. GC10719 Toceranib

    托西尼布; SU11654; PHA 291639E

     A multi-targeted receptor tyrosine kinase inhibitor
  43. GC11622 TG 100801

    4-氯-3-[5-甲基-3-[[4-[2-(1-吡咯烷基)乙氧基]苯基]氨基]-1,2,4-苯并三嗪-7-基]苯酚苯甲酸酯,TG100801;TG-100801

     TG 100801 是一种前药，可通过在开发过程中的去酯化作用产生 TG 100572，以治疗年龄相关性黄斑变性。 TG 100572 是一种多靶点激酶抑制剂，可抑制受体酪氨酸激酶和 Src 激酶；对于 VEGFR1、VEGFR2、FGFR1、FGFR2、PDGFRβ、Fgr、Fyn、Hck、Lck、Lyn、Src、Yes ， 分别。
  44. GC14315 SU14813 maleate

    5-[(Z)-(5-氟-1,2-二氢-2-氧代-3H-吲哚-3-亚基)甲基]-N-[(2S)-2-羟基-3-(4-吗啉基)丙基]-2,4-二甲基-1H-吡咯-3-甲酰胺马来酸盐,SU-14813 maleate;SU 14813 maleate

     A dual VEGFR and PDGFR family kinase inhibitor
  45. GC14733 SU14813

    SU-14813;SU 14813

     A dual VEGFR and PDGFR family kinase inhibitor
  46. GC14660 SU 5402

    2-[(1,2-二氢-2-氧代-3H-吲哚-3-亚基)甲基]-4-甲基-1H-吡咯-3-丙酸,SU-5402; SU5402

     An inhibitor of VEGFR2, FGFR1, and PDGFRβ
  47. GC14534 Regorafenib monohydrate

    瑞格非尼一水合物,BAY 73-4506 monohydrate

     A multi-kinase inhibitor
  48. GC14606 Regorafenib hydrochloride

    瑞戈非尼盐酸盐; BAY 73-4506 hydrochloride

     A multi-kinase inhibitor
  49. GC13264 Ki20227

    Ki 20227;Ki-20227

     A c-Fms kinase inhibitor
  50. GC15263 Imatinib hydrochloride

    甲磺酸伊马替尼对照品,STI571 hydrochloride;STI 571 hydrochloride;STI-571 hydrochloride

     V-Abl/c-Kit/PDGFR inhibitor
  51. GC11171 DCC-2618

    DCC2618;DCC 2618

     A dual inhibitor of c-Kit and c-MET

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