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Home >> Signaling Pathways >> Tyrosine Kinase >> Src

Src(Src激酶)

Src (proto-oncogene tyrosine-protein kinase) is a non-receptor protein tyrosine kinase family including 9 members and promotes survival, angiogenesis, proliferation and invasion pathways.

Products for  Src

  1. Cat.No. 产品名称 Information
  2. GC33181 T338C Src-IN-2

    T338CSrc-IN-2是突变型c-Src激酶抑制剂，IC50值317nM，还能抑制T338C/V323A和T338C/V323S双突变Src活性，IC50值57和19nM。
  3. GC33168 T338C Src-IN-1 T338CSrc-IN-1是突变型c-SrcT338C高效抑制剂，IC50值111nM。对WTSrc活性弱10倍以上。
  4. GC32992 7-Hydroxy-4-chromone (7-Hydroxychromone)

    7-羟基色原酮,7-Hydroxychromone

     7-Hydroxychromone is an inhibitor of Src kinase with IC50 of <300 μM.
  5. GC32875 AZM475271 (M475271)

    M475271

     An inhibitor of c-Src kinase
  6. GC32835 PP58

    PP58是吡啶[2,3-d]嘧啶化合物，抑制PDGFR，FGFR和Src家族活性的IC50值在纳摩尔级。
  7. GC32825 eCF506 An inhibitor of Src kinases
  8. GC32797 AD80 AD80, a multikinase inhibitor, shows strong activity against human RET (c-RET), BRAF, S6K, and SRC but were much less active than either AD57 or AD58 against mTOR. The IC50 value for RET is 4 nM.
  9. GC31701 RK-24466 (KIN 001-51)

    KIN 001-51

     A selective inhibitor of lymphocyte-specific protein tyrosine kinase
  10. GC19366 UM-164

    DAS-DFGO-II

     An inhibitor of Src and p38 MAPK kinases
  11. GC18438 CGP 77675 An inhibitor of Src family kinases
  12. GC17669 AMG-47A

    4-甲基-3-[2-[[2-(4-吗啉基)乙基]氨基]-6-喹唑啉基]-N-[3-(三氟甲基)苯基]苯甲酰胺

     A multi-kinase inhibitor
  13. GC17500 SU6656 Inhibitor of Src kinases
  14. GC13600 WH-4-023

    Dual LCK/SRC inhibitor

     An inhibitor of Lck and Src
  15. GC17638 KB SRC 4 KB SRC 4 是一种有效的、高选择性的 c-Src 抑制剂，Ki 为 44 nM，Kd 为 86 nM，对 c-Abl 没有抑制作用，最高可达 125 μM; KB SRC 4 具有抗肿瘤活性。
  16. GC10775 MLR 1023

    托利咪酮,MLR-1023

     An allosteric Lyn kinase activator
  17. GC12958 ER 27319 maleate Syk激酶的选择性抑制剂
  18. GC16957 Src I1

    7-二甲氧基-N-(4-苯氧基苯基)-氨基喹唑啉,Src Kinase Inhibitor 1; Src-l1

     A potent inhibitor of Src kinases
  19. GC11526 N-Acetyl-O-phosphono-Tyr-Glu Dipentylamide Phosphopeptide for binding to the src SH2 domain
  20. GC12746 N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu Phosphopeptide ligand for the src SH2 domain
  21. GC17137 pp60 c-src (521-533) (phosphorylated) Peptide corresponding to the pp60c-src carboxy terminal regulatory domain
  22. GC13797 PP 3

    4-氨基-1-苯基吡唑[3,4-D]嘧啶

     A negative control for Src tyrosine kinase inhibitors
  23. GC15211 Damnacanthal Damnacanthal 是一种从海巴戟根中分离出来的蒽醌。
  24. GC15000 Herbimycin A

    除莠霉素A

     An inhibitor of tyrosine kinases and Hsp90
  25. GC10523 KX1-004 An inhibitor of Src-PTK
  26. GC17789 A 419259 trihydrochloride

    7-[反式-4-(4-甲基-1-哌嗪基)环己基]-5-(4-苯氧基苯基)-7H-吡咯并[2,3-D]嘧啶-4-胺三盐酸盐,RK 20449 trihydrochloride

     An inhibitor of Src family kinases
  27. GC11696 1-NM-PP1

    4-氨基1-叔丁基-3-(1'-萘甲基)吡唑并[3,4-D]嘧啶,PP1 Analog II

     Inhibitor of modified 'analog-sensitive' kinases
  28. GC14292 Apatinib Mesylate

    阿帕替尼

    A selective VEGFR2 inhibitor
  29. GC14007 DCC-2036 (Rebastinib)

    N-[3-叔丁基-1-(喹啉-6-基)-1H-吡唑-5-基]-N'-[2-氟-4-[(2-(甲基氨基甲酰基)吡啶-4-基)氧]苯基]脲,DCC-2036

     An orally bioavailable tyrosine kinase inhibitor
  30. GC11003 PP121 A potent dual inhibitor of tyrosine and phosphoinositide kinases
  31. GC14288 KX2-391

    5-[4-[2-(4-吗啉基)乙氧基]苯基]-N-(苯基甲基)-2-吡啶乙酰胺,KX2-391; KX-01

     A Src kinase inhibitor
  32. GC13592 PD173955

    6-(2,6-二氯苯基)-8-甲基-2-[[3-(甲硫基)苯基]氨基]吡啶并[2,3-D]嘧啶-7(8H)-酮

     A tyrosine kinase inhibitor
  33. GC12185 ZM 306416

    CB 676475

     A VEGF receptor kinase inhibitor
  34. GC14332 NVP-BHG712

    4-甲基-3-[[1-甲基-6-(3-吡啶基)-1H-吡唑并[3,4-D]嘧啶-4-基]氨基]-N-[3-(三氟甲基)苯基]苯甲酰胺,BHG712

     A selective EphB4 kinase inhibitor
  35. GC10048 MNS

    3,4-亚甲二氧-beta-硝基苯乙烯,NSC 170724; 5-(2-Nitrovinyl)benzodioxole

     An inhibitor of Src, Syk, and platelet aggregation
  36. GC12172 1-Naphthyl PP1

    4-氨基-1-叔丁基-3-(1'-萘基)吡唑并[3,4-D]嘧啶,1-NA-PP 1

     Inhibitor of modified ‘analog-sensitive’ kinases
  37. GC14807 Fingolimod (FTY720) HCl

    盐酸芬戈莫德; FTY720

     芬戈莫德(FTY720)是一种免疫抑制剂,通常用于治疗多发性硬化症,也有抗癌作用,可以作为HDACi(组蛋白脱乙酰酶抑制剂)。
  38. GC14396 Ponatinib (AP24534)

    普纳替尼; AP24534

     An inhibitor of native and mutant Bcr-Abl
  39. GC15197 Saracatinib (AZD0530)

    塞卡替尼; AZD0530

     A dual inhibitor of c-Src and Abl
  40. GC17473 Pelitinib (EKB-569)

    培利替尼; EKB-569; WAY-EKB 569

     An EGFR receptor tyrosine kinase inhibitor
  41. GC13410 Masitinib (AB1010)

    马赛替尼; AB1010

     An inhibitor of c-Kit
  42. GC13343 Bosutinib (SKI-606)

    伯舒替尼,SKI-606

     An inhibitor of Src and Abl kinases
  43. GC10344 PP 2 (AG 1879)

    AGL 1879

     A selective inhibitor of Src tyrosine kinases
  44. GC17990 PP 1

    蛋白磷酸酯酶-1(抗原),AGL 1872; EI 275

     Potent, selective Src family tyrosine kinase inhibitor
  45. GC13102 XL228

    N4-(5-环丙基-1H-吡唑-3-基)-N2-[[3-异丙基-5-异恶唑基]甲基]-6-(4-甲基-1-哌嗪基)-2,4-嘧啶二胺,XL-228;XL 228

     A tyrosine kinase inhibitor
  46. GC11622 TG 100801

    4-氯-3-[5-甲基-3-[[4-[2-(1-吡咯烷基)乙氧基]苯基]氨基]-1,2,4-苯并三嗪-7-基]苯酚苯甲酸酯,TG100801;TG-100801

     TG 100801 是一种前药，可通过在开发过程中的去酯化作用产生 TG 100572，以治疗年龄相关性黄斑变性。 TG 100572 是一种多靶点激酶抑制剂，可抑制受体酪氨酸激酶和 Src 激酶；对于 VEGFR1、VEGFR2、FGFR1、FGFR2、PDGFRβ、Fgr、Fyn、Hck、Lck、Lyn、Src、Yes ， 分别。
  47. GC13117 Lck Inhibitor

    6-(2,6-二甲基苯基)-2-[[4-(4-甲基-1-哌嗪基)苯基]氨基]-嘧啶并[5',4':5,6]嘧啶并[1,2-A]苯并咪唑-5(6H)-酮

     A selective inhibitor of lymphocyte-specific protein tyrosine kinase
  48. GC10222 KX2-391 dihydrochloride

    5-[4-[2-(4-吗啉基)乙氧基]苯基]-N-(苯基甲基)-2-吡啶乙酰胺盐酸盐,KX2-391 2HCl; KX2-391

     A Src kinase inhibitor
  49. GC16519 ENMD-2076

    6-(4-甲基-1-哌嗪基)-N-(5-甲基-1H-吡唑-3-基)-2-[(1E)-2-苯乙烯基]-4-嘧啶胺

     A multi-kinase inhibitor
  50. GC12145 ENMD-2076 L-(+)-Tartaric acid ENMD-2076 L-(+)-Tartaric acid 是一种多靶点激酶抑制剂，对 Aurora A、Flt3、KDR/VEGFR2、Flt4/VEGFR3、FGFR1 的 IC50 为 1.86、14、58.2、15.9、92.7、70.8、56.4 nM , FGFR2, Src, PDGFRα, 分别。
  51. GC15568 Dasatinib (BMS-354825)

    达沙替尼; BMS-354825

     An inhibitor of Abl and Src

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