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Home >> Signaling Pathways >> Ubiquitination/ Proteasome

Ubiquitination/ Proteasome(泛素化/蛋白酶体)

  1. Cat.No. 产品名称 Information
  2. GC32468 Lanatoside C

    毛花甙丙

    Lanatoside C is a cardiac glycoside with antiviral and anti-tumor activity. Lanatoside C induces G2/M cell cycle arrest and induces autophagy and apoptosis via attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR signaling pathways.
  3. GC32411 FR 167653 (FR 167653 sulfate)

    FR 167653 sulfate

     FR 167653 (FR 167653硫酸盐) (FR 167653 (FR 167653硫酸盐))，一种具有口服活性和选择性的p38 MAPK抑制剂，是TNF-α的强效抑制剂；和 IL-1β；通过特异性抑制 p38 MAPK 活性产生。
  4. GC32407 Rpn11-IN-1

    Capzimin intermediate

     Rpn11-IN-1是一种有效的选择性蛋白酶体亚基Rpn11抑制剂，IC50为390nM。
  5. GC32232 Pyriproxyfen (S-31183)

    吡丙醚; S-31183

     A pyridine insecticide
  6. GC32209 ITX5061 ITX5061是一个II型p38MAPK抑制剂，也是清道夫受体B1(SR-B1)的拮抗剂。
  7. GC32152 Lumefantrine (Benflumetol)

    苯芴醇; Benflumetol

     An antimalarial drug
  8. GC32107 Peretinoin (NIK333)

    NIK333

     Peretinoin (NIK333) 是一种具有维生素 A 样结构的口服无环类维生素 A，可靶向类维生素 A 核受体，如类维生素 X 受体 (RXR) 和视黄酸受体 (RAR)。
  9. GC32078 Clioquinol (Iodochlorhydroxyquin)

    氯碘羟喹,Iodochlorhydroxyquin

    A metal-chelating antimicrobial agent
  10. GC32048 Emetine dihydrochloride hydrate

    吐根碱盐酸盐水合物

    An alkaloid with diverse biological activities
  11. GC31988 p38α inhibitor 1

    p38αinhibitor1是p38α的抑制剂，来自专利WO2008076265A1。
  12. GC31964 Sulfosuccinimidyl oleate

    Sulfo-N-succinimidyl oleate

    An irreversible inhibitor of CD36
  13. GC31935 Trifarotene (CD5789)

    曲法罗汀; CD5789

     Trifarotene (CD5789) (CD5789) 是一种有效的选择性 RARγ；激动剂。
  14. GC31924 AZD7624 AZD7624是一种可吸入的p38抑制剂，具有高效的抗炎活性。
  15. GC31899 KZR-504 KZR-504是具有口服活性的、高度选择性的免疫原体低分子质量多肽2(LMP2)的抑制剂、其对LMP2和LMP7的IC50值分别为51nM,4.274μM。
  16. GC31809 Yangonin

    甲氧醉椒素

     A kavalactone with affinity for the CB1 receptor
  17. GC31717 Ginkgetin

    银杏双黄酮

     A biflavonoid with diverse biological activities
  18. GC31705 Sofalcone

    索法酮

     Gastroprotective chalcone derivative
  19. GC31697 Dilmapimod (SB-681323)

    度马莫得; SB-681323; GW 681323

     Dilmapimod (SB-681323,GW 681323) is a potent p38 MAPK inhibitor that potentially suppresses inflammation in chronic obstructive pulmonary disease.
  20. GC31665 (R)-BPO-27 (R)-BPO-27是有效的CFTR抑制剂，IC50值为4nM。
  21. GC31586 Monacolin J (Antibiotic MB 530A)

    辛伐他汀内酯二醇,Antibiotic MB 530A; Lovastatin diol lactone

     Monacolin J (Antibiotic MB 530A) 是一种胆固醇生物合成抑制剂，可抑制 HMG-CoA 还原酶的活性。
  22. GC31563 FK-448 Free base FK-448Freebase是一种有效的，特异性的糜蛋白酶(chymotrypsin)抑制剂，IC50值为720nM。
  23. GC31395 PX20606 trans racemate (PX-102 trans racemate)

    CPDD1220反式消旋体,PX-102 trans racemate

     PX20606 trans racemate (PX-102 trans racemate) (PX-102 trans racemate) 是一种 FXR 激动剂，在 FRET 和 M1H 试验中对 FXR 的 EC50 分别为 32 和 34 nM。
  24. GC31386 (-)-PX20606 trans isomer ((-)-PX-102 trans isomer)

    PX-20606手性,(-)-PX-102 trans isomer; (-)-PX-104

     (-)-PX20606 trans isomer ((-)-PX-102 trans isomer) 是一种 FXR 激动剂，在 FRET 和 M1H 试验中对 FXR 的 EC50 分别为 18 和 29 nM。
  25. GC31317 Sitagliptin (MK0431)

    西格列汀; MK-0431

     Sitagliptin (MK-0431) is an oral and highly selective DPP-4 inhibitor with an IC50 of 18 nM. It is used for the treatment of type 2 diabetes.
  26. GC31239 SA72 SA72是高度选择性的脂肪酸酰胺水解酶(FAAH)抑制剂。
  27. GC31170 Calmodulin-Dependent Protein Kinase II 290-309

    A CaMKII inhibitor
  28. GC31058 FR 167653 free base FR-167653是一种选择性的p38MAPK抑制剂。
  29. GC30992 Paroxetine hydrochloride hemihydrate (BRL29060 hydrochloride hemihydrate)

    盐酸帕罗西汀半水合物; BRL29060 hydrochloride hemihydrate; BRL29060A hemihydrate

     Paroxetine HCl (BRL-29060A, FG-7051) is an antidepressant drug of the SSRI type.
  30. GC30990 Calcineurin substrate

    钙调神经磷酸酶底物

     A synthetic peptide substrate
  31. GC30884 LX2343 An inhibitor of BACE1 and PI3K
  32. GC30871 Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride)

    6-羟基多巴胺盐酸盐; 6-Hydroxydopamine hydrochloride; 6-OHDA hydrochloride

     Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride)（6-OHDA）是神经递质多巴胺的拮抗剂。
  33. GC30842 Androsterone (5α-Androstan-3α-ol-17-one)

    雄酮; 5α-Androstan-3α-ol-17-one

    An androgenic steroid
  34. GC30790 Triflupromazine hydrochloride

    盐酸三氟丙嗪

     A phenothiazine with diverse biological activities
  35. GC30787 Sertindole (Lu 23-174)

    舍吲哚; Lu 23-174

     An atypical antipsychotic
  36. GC30785 4E2RCat 4E2RCat是eIF4E-eIF4G相互作用的抑制剂，IC50值为13.5μM。
  37. GC30761 α-Hydroxylinoleic acid

    α-羟基油酸; α-Hydroxylinoleic acid

     ABTL0812 (α-Hydroxylinoleic acid, LP-10218, SCLN-0812) inhibits Akt/mTOR axis by inducing the overexpression of TRIB3 and activating autophagy in lung squamous carcinoma cell lines. ABTL0812 also induces AMPK activation and ROS accumulation.
  38. GC30751 FAAH-IN-1 FAAH-IN-1是脂肪酸酰胺水解酶(FAAH)抑制剂，对大鼠和人FAAH的IC50值分别为145nM和650nM。
  39. GC30744 Norepinephrine (Adrenor)

    去甲肾上腺素; Levarterenol; L-Noradrenaline

    (-)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline) is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively.
  40. GC30676 MAPK13-IN-1 MPAK13-IN-1是MAPK13(p38δ)的一个抑制剂，其IC50值为620nM。
  41. GC30646 Skatole(3-Methylindole)

    粪臭素; 3-Methylindole; 3-Methyl-1H-indole

     Skatole (3-methylindole, Scatole) is a mildly toxic white crystalline organic compound that occurs naturally in feces. It has a fairly broad bacteriostatic effect.
  42. GC30609 p38 MAPK-IN-2 p38MAPK-IN-2是一种p38kinase的抑制剂。
  43. GC30608 Ipsalazide

    伊普柳氮

    Ipsalazide是一种新的柳氮磺吡啶类似物，旨在释放胃肠道中的5-氨基水杨酸和无毒载体分子。
  44. GC30565 BAR502 A dual agonist of GP-BAR1 and FXR
  45. GC30537 BPO-27 racemate BPO-27racemate是有效的CFTR抑制剂，IC50值为8nM。
  46. GC30366 FAAH-IN-2

    4-(3-氯-4-氟苯氨基)-7-甲氧基喹唑啉-6-醇,O-Desmorpholinopropyl Gefitinib

     FAAH-IN-2是摘自专利WO/2008/100977A2中的FAAH抑制剂。
  47. GC30360 Cresol (Cresol mixture of isomers) Cresol是一种有机化合物，是芳香族有机化合物广泛存在的天然及合成基团。
  48. GC30356 Metofenazate (Methophenazine)

    美托奋乃酯,Methophenazine

     Metofenazate (Methophenazine) 是一种选择性钙调蛋白抑制剂。
  49. GC30343 Selenomethionine (Seleno-DL-methionine)

    硒代蛋氨酸; Seleno-DL-methionine; DL-Selenomethionine

    硒代蛋氨酸（Seleno-DL-methionine）是一种天然存在的含硒氨基酸，是硒的常见天然食物来源。
  50. GC30263 Glucosamine (D-Glucosamine)

    氨基葡萄糖; D-Glucosamine; Chitosamine

     Glucosamine (2-amino-2-deoxy-D-glucose) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. It is commonly used as a treatment for osteoarthritis. Glucosamine（GS） treatment selectively downregulates HIF-1α at the protein level in YD-8 cells via interference of production of the citric acid cycle metabolites.
  51. GC30158 p38-α MAPK-IN-1

    p38-α MAPK-IN-1 is an inhibitor of p38-α, with IC50 value of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay.

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