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Home >> Signaling Pathways >> Ubiquitination/ Proteasome

Ubiquitination/ Proteasome(泛素化/蛋白酶体)

  1. Cat.No. 产品名称 Information
  2. GC30072 Dansylcadaverine (Monodansyl cadaverine)

    丹酰尸胺; Monodansyl cadaverine

    A fluorescent marker for autophagic vacuoles
  3. GC30056 Danthron (Dantron)

    1,8-二羟基蒽醌; Dantron; Chrysazin; 1,8-Dihydroxyanthraquinone

     Danthron (Chrysazin, Antrapurol) functions in regulating glucose and lipid metabolism by activating AMPK. Danthron is a natural product extracted from the traditional Chinese medicine rhubarb. Danthron used to be a laxativa and now is currently used as an antioxidant in synthetic lubricants, in the synthesis of experimental antitumor agents, as a fungicide and as an intermediate for making dyes.
  4. GC30054 Dantrolene sodium hemiheptahydrate (Dantrolene sodium hydrate)

    丹曲林钠,Dantrolene sodium hydrate

     Dantrolene sodium hemiheptahydrate (Dantrium) ia a skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber.
  5. GC30011 20-Deoxyingenol

    20-去氧巨大戟醇；20-去氧巨大戟萜醇

     A diterpenoid with antioxidant and osteoprotective activities
  6. GC19479 AZ304 AZ304 是一种 ATP 竞争性双 BRAF 激酶抑制剂，有效抑制野生型 BRAF、V600E 突变型 BRAF 和野生型 CRAF，IC50 分别为 79 nM、38 nM 和 68 nM。 AZ304 对其他激酶也有显着影响，例如 p38 (IC50, 6 nM)、CSF1R (IC50, 35 nM)。抗肿瘤活性。
  7. GC19453 Autophinib A VPS34 inhibitor
  8. GC19451 SBI-0640756

    SBI-756

     SBI-0640756 (SBI-756) 是 eIF4G1 的抑制剂，可破坏 eIF4F 复合物。
  9. GC19411 IITZ-01 IITZ-01 是一种有效的溶酶体自噬抑制剂，具有单剂抗肿瘤活性，对 PI3Kγ 的 IC50 为 2.62 μM。
  10. GC19421 LY2562175 An FXR agonist
  11. GC19400 JPH203 Dihydrochloride

    KYT-0353

     An inhibitor of LAT1
  12. GC19396 H 89

    N-[2-[P-溴苯丙烯盐基氨基]乙基]-5-异喹啉磺酰胺

    A PKA inhibitor
  13. GC19366 UM-164

    DAS-DFGO-II

     An inhibitor of Src and p38 MAPK kinases
  14. GC19363 Tropifexor

    LJN452

     An FXR agonist
  15. GC19325 SD 0006

    3-[N-(2-羟基乙酰基)-4-哌啶基]-4-(4-嘧啶基)-5-(4-氯苯基)吡唑,SD-06

     An inhibitor of p38α MAPK
  16. GC19304 R1487 Hydrochloride An inhibitor of p38α MAPK
  17. GC19293 PFK-158 PFK-158 是一种有效的选择性 PFKFB3 抑制剂，通过减少癌细胞中葡萄糖的摄取、ATP 的产生、乳酸的释放以及诱导细胞凋亡和自噬，显示出广泛的抗肿瘤活性.PFK-158 在 EC 细胞中以剂量和时间依赖性方式抑制细胞活力。
  18. GC19279 PD-166866 A potent inhibitor of FGFR1
  19. GC19237 Lys01 trihydrochloride

    Lys01 trihydrochloride

     An inhibitor of autophagy
  20. GC19236 LYN-1604 A ULK1 activator
  21. GC19232 LY2955303 A potent RARγ antagonist
  22. GC19188 HA15 An inhibitor of GRP78
  23. GC19169 GLPG1837

    ABBV-974

     A CFTR potentiator
  24. GC19083 Briciclib

    ON 014185

     An eIF4E inhibitor
  25. GC19040 AS1842856

    5-氨基-7-(环己基氨基)-1-乙基-6-氟-1,4-二氢-4-氧代-3-喹啉羧酸

     AS1842856是一种细胞渗透性抑制剂,抑制Foxo1转录活性,IC50=33 nM。
  26. GC19035 AR7 A RARα antagonist
  27. GC19019 Acumapimod

    BCT197

     An inhibitor of p38α MAPK
  28. GC18487 BC-1215 An inhibitor of FBXO3
  29. GC18304 Bicyclol

    双环醇; SY801

     A hepatoprotective agent
  30. GC18269 SR 18292 SR 18292是一种过氧化物酶体增殖物激活受体γ（PPARγ）共激活因子-1α（PGC-1α）的抑制剂，可促进PGC-1α乙酰化，抑制糖异生基因的表达，并减少肝细胞中葡萄糖的产生。
  31. GC18212 Cilofexor

    GS-9674

     An FXR ligand
  32. GC18174 BIA 10-2474

    3-(1-(环己基(甲基氨基甲酰基)-1H-咪唑-4-基)吡啶1-氧化物

     An inhibitor of FAAH
  33. GC15168 Urolithin A

    尿石素A

    A metabolite of ellagic acid with diverse biological activities
  34. GC14820 (S)-Naproxen

    萘普生; (S)-Naproxen

     An NSAID and COX inhibitor
  35. GC14918 10074-G5

    N-2-联苯基-7-硝基-2,1,3-苯并恶二唑-4-胺

     An inhibitor of c-Myc/Max dimerization
  36. GC17768 Lasalocid

    那塞罗; Lasalocid-A; Ionophore X-537A; Antibiotic X-537A

     An ionophore antibiotic
  37. GC13063 N-Benzylpalmitamide

    N-苄基棕榈酰胺,N-Benzylhexadecanamide

     A long-chain fatty acid amide
  38. GC10593 BMS-582949 hydrochloride A p38α MAP kinase inhibitor
  39. GC14749 ALLO-1 A smoothened antagonist
  40. GC11989 Nortriptyline (hydrochloride)

    盐酸去甲替林; Desmethylamitriptyline hydrochloride; Desitriptilina hydrochloride

     A tricyclic antidepressant
  41. GC10133 JNJ-42165279

    N-(4-氯-3-吡啶基)-4-[(2,2-二氟-1,3-苯并二恶茂-5-基)甲基]-1-哌嗪甲酰胺

     An irreversible FAAH inhibitor
  42. GC16699 HMB-Val-Ser-Leu-VE A vinyl ester tripeptide inhibitor of proteasome trypsin-like activity
  43. GC13311 Triclosan

    三氯生

     A broad-spectrum antibacterial agent
  44. GC10331 Ebselen

    依布硒; SPI-1005; PZ-51; CCG-39161

     A peroxynitrite scavenger
  45. GC12235 Sitagliptin (phosphate)

    磷酸西他列汀; MK-0431 phosphate

     A DPP-4 inhibitor
  46. GC14591 Hemin chloride

    氯化血红素; Hemin chloride

     氯化血红素是血红素加氧酶(HO)-1的底物，可诱导多种细胞表达HO-1，发挥抗氧化和抗炎作用。
  47. GC17912 C598-0466

    USP7 inhibitor
  48. GC10601 Ubiquitin Isopeptidase Inhibitor I

    NSC 144303

     An activator of caspases
  49. GC14413 KJ Pyr 9 An inhibitor of c-Myc and v-Myc interaction with Max
  50. GC15814 Pamapimod (R-1503, Ro4402257)

    Ro4402257; R1503

     An orally bioavailable inhibitor of p38α MAP kinase
  51. GC10436 VPS34-IN1

    Vacuolar Protein Sorting 34 Inhibitor 1, Vps34 Inhibitor 1

     A potent and selective inhibitor of Vps34

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