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Home >> Signaling Pathways >> Ubiquitination/ Proteasome

Ubiquitination/ Proteasome(泛素化/蛋白酶体)

  1. Cat.No. 产品名称 Information
  2. GC15605 Ezetimibe

    依泽替米贝; SCH 58235

     A cholesterol transport inhibitor
  3. GC13029 AZD2014

    3-[2,4-双((3S)-3-甲基吗啉-4-基)吡啶并[5,6-E]嘧啶-7-基]-N-甲基苯甲酰胺,AZD 2014; AZD-2014

     A potent dual mTORC1/2 inhibitor
  4. GC16526 Atropine

    阿托品; Tropine tropate; DL-Hyoscyamine

     A non-selective muscarinic acetylcholine receptor antagonist
  5. GC10710 3-Methyladenine

    3-甲基腺嘌呤; 3-MA

     3-甲基腺嘌呤是一种经典的自噬抑制剂。
  6. GC12730 Pazopanib Hydrochloride

    盐酸帕唑帕尼; GW786034 (Hydrochloride)

     A multi-kinase inhibitor
  7. GC15455 VX-809

    鲁玛卡托; VX-809; VRT 826809

     A F508del-CFTR corrector
  8. GC13037 CX-4945 (Silmitasertib)

    CX 4945;CX4945

     A potent, orally bioavailable CK2 inhibitor
  9. GC14482 Verteporfin

    维替泊芬; CL 318952

     维替泊芬是一种有效的 PD-L1 表达抑制剂，用于治疗年龄相关性黄斑变性、鲜红斑痣和癌症。
  10. GC10970 WP1130

    WP 1130; WP-1130

     A deubiquitinase inhibitor
  11. GC15904 PP242

    PP242; PP-242

     Potent inhibitor of mTOR kinase in both mTORC1 and mTORC2
  12. GC12573 Temsirolimus

    西罗莫司脂化物,Torisel;CCI-779;CCI 779;CCI779

     A specific inhibitor of mTOR activity
  13. GC15818 RAF265

    CHIR-265;RAF 265;RAF-265;CHIR265

     A B-Raf and VEGFR2 inhibitor
  14. GC10131 Torin 1

    1-[4-[4-(1-氧代丙基)-1-哌嗪基]-3-(三氟甲基)苯基]-9-(3-喹啉基)苯并[H]-1,6-萘啶-2(1H)-酮,Torin1;Torin-1

    Selective inhibitor of mTOR
  15. GC15680 Perifosine

    哌立福新; KRX-0401; NSC 639966; D21266

    Perifosine 是 Akt 的抑制剂 。
  16. GC10261 PH-797804

    PH797804;PH 797804

     A selective p38 MAPK inhibitor
  17. GC14906 Crenolanib (CP-868596)

    [1-[2-[5-(3-甲基氧杂环丁烷-3-基甲氧基)苯并咪唑-1-基]喹啉-8-基]哌啶-4-基]胺,CP-868596;CP 868596;CP868596

     An inhibitor of PDGFRα/β and FLT3
  18. GC16436 Tenovin-6 A small molecule activator of p53
  19. GC12021 GDC-0349

    N-ETHYL-N'-[4-[5,6,7,8-四氢-4-[(3S)-3-甲基-4-吗啉基]-7-(3-氧杂环丁基)吡啶并[3,4-D]嘧啶-2-基]苯基]脲

     A potent inhibitor of mTOR
  20. GC14920 VX-661

    VX-661

     An investigational compound that promotes the maturation of delta F508 CFTR
  21. GC10944 Butein

    紫铆因; 2’,3,4,4’-tetrahydroxy Chalcone

     A plant polyphenol
  22. GC11752 AZD5363

    4-氨基-N-[(1S)-1-(4-氯苯基)-3-羟基丙基]-1-(7H-吡咯并[2,3-D]嘧啶-4-基)-4-哌啶甲酰胺,AZD5363

     A pan-Akt inhibitor
  23. GC10359 GANT61

    2,2'-[[二氢-2-(4-吡啶基)-1,3(2H,4H)-嘧啶二基]二(亚甲基)]二[N,N-二甲基苯胺],NSC 136476

     GANT61 能够有效阻断 GLI1 和 GLI2 诱导的转录，IC50 为 5 μM。
  24. GC10395 Dynasore Dynasore 作为 GTPase 抑制剂，可以快速、可逆地抑制发动蛋白活性，从而阻止内吞作用。
  25. GC12843 MEK162 (ARRY-162, ARRY-438162)

    贝美替尼,MEK162; ARRY-162; ARRY-438162

     A MEK1/2 inhibitor
  26. GC10596 T0901317

    N-(2,2,2-三氟乙基)-N-[4-[2,2,2-三氟-1-羟基-1-(三氟甲基)乙基]苯基]苯磺酰胺

     Selective agonist for LXRα and LXRβ
  27. GC17295 10058-F4

    5-(4-乙基苯亚甲基)

     10058-F4是一种c-Myc抑制剂，抑制c-Myc-Max二聚化，阻止c-Myc靶基因表达的转录激活。
  28. GC11015 PD168393 An irreversible EGFR kinase inhibitor
  29. GC16380 AZD8055

    CCG-168

     AZD8055是一种新型的ATP竞争性mTOR抑制剂，IC50 为0.8 nmol/L，Ki为1.3 nmol/L。
  30. GC17615 Quizartinib (AC220)

    奎扎替尼; AC220

     An inhibitor of FLT3
  31. GC14289 Fasudil (HA-1077) HCl

    盐酸法舒地尔; HA-1077 Hydrochloride; AT-877 Hydrochloride

     Fasudil（法舒地尔；HA-1077；AT877）是一种非特异性RhoA/ROCK抑制剂，对ROCK1的Ki为0.33μM，IC50为0.158μM，对ROCK2和PKA、PKC、PKG的IC50分别为4.58μM、12.30μM、1.650μM。
  32. GC11497 BIRB 796 (Doramapimod)

    达马莫德; BIRB 796

     A potent inhibitor of p38 MAPK
  33. GC16835 LY2228820

    5-[2-(叔丁基)-4-(4-氟苯基)-1H-咪唑-5-基]-3-(2,2-二甲基丙基)-3H-咪唑并[4,5-B]吡啶-2-胺甲磺酸盐,LY2228820 dimesylate

     A potent inhibitor of p38α MAP kinase
  34. GC16851 AZD6482

    2-[[(1R)-1-[7-甲基-2-(4-吗啉)-4-氧代-4H-吡啶并[1,2-A]嘧啶-9-基]乙基]氨基]苯甲酸,KIN-193

     A PI3Kβ inhibitor
  35. GC14574 Tigecycline

    替加环素; GAR-936

     A glycylcycline antibiotic
  36. GC15459 Tazarotene

    他扎罗汀; AGN 190168

     A retinoid prodrug
  37. GC14396 Ponatinib (AP24534)

    普纳替尼; AP24534

     An inhibitor of native and mutant Bcr-Abl
  38. GC12474 AS-605240

    5-(6-喹喔啉亚甲基)-2,4-噻唑啉二酮

     A potent inhibitor of PI3-kinase γ
  39. GC16868 Sulfasalazine

    柳氮磺吡啶; NSC 667219

     A prodrug form of 5-aminosalicylic acid
  40. GC13882 Ranolazine 2HCl

    盐酸雷诺嗪; CVT 303 dihydrochloride; RS 43285

     A piperazine derivative with cardioprotective activity
  41. GC18072 Prazosin HCl

    哌唑嗪盐酸盐

     An α1-adrenergic receptor antagonist
  42. GC15197 Saracatinib (AZD0530)

    塞卡替尼; AZD0530

     A dual inhibitor of c-Src and Abl
  43. GC11473 Irinotecan

    伊立替康; (+)-Irinotecan; CPT-11

     Irinotecan是一种拓扑异构酶抑制剂，主要用于治疗结直肠癌。Irinotecan可通过与拓扑异构酶 I-DNA 复合物结合，阻止 DNA 链的再连接，并导致 DNA 双链断裂和细胞死亡 。
  44. GC14701 Zoledronic Acid

    唑来膦酸; Zoledronate; CGP 42446; CGP42446A; ZOL 446

     A bisphosphonate that inhibits bone resorption
  45. GC14238 Brivanib Alaninate (BMS-582664)

    1-[[4-[(4-氟-2-甲基-1H-吲哚-5-基)氧基]-5-甲基吡咯并[2,1-F][1,2,4]三嗪-6-基]氧基]-2-丙醇L-丙氨酸酯,BMS-582664

     A prodrug form of brivanib
  46. GC12963 NVP-AEW541

    AEW541

     An IGF-1R inhibitor
  47. GC17094 Acitretin

    阿维A; Ro 10-1670

     A retinoid
  48. GC11692 Brivanib (BMS-540215)

    布立尼布; BMS-540215

     A VEGFR1, VEGFR2, and FGFR1 inhibitor
  49. GC10662 WYE-354

    4-[6-[4-[(甲氧羰基)氨基]苯基]-4-(4-吗啉基)-1H-吡唑并[3,4-D]嘧啶-1-基]-1-哌啶羧酸甲酯

     Potent inhibitor of mTOR in both mTORC1 and mTORC2
  50. GC13696 GSK690693

    4-[2-(4-氨基-1,2,5-恶二唑-3-基)-1-乙基-7-[(3S)-3-哌啶基甲氧基]-1H-咪唑并[4,5-C]吡啶-4-基]-2-甲基-3-丁炔-2-醇

     GSK690693 是一种 ATP 竞争性低纳摩尔 Akt 激酶抑制剂，对 Akt1、2 和 3 的 IC50 值分别为 2、13 和 9 nM。
  51. GC16421 Cediranib (AZD217)

    西地尼布; AZD2171

     An inhibitor of VEGF receptor tyrosine kinases

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