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Home >> Signaling Pathways >> Ubiquitination/ Proteasome

Ubiquitination/ Proteasome(泛素化/蛋白酶体)

Cat.No. 产品名称 Information
GC15854 Mefloquine hydrochloride
盐酸甲氟喹,Mefloquin hydrochloride
An antimalarial compound
GC17874 Matrine
苦参碱; Matridin-15-one; Vegard; α-Matrine
苦参碱（Matrine）是一种存在于槐属植物中的生物碱，可作为 kappa 阿片受体和µ-受体激动剂。
GC15094 LY2183240
5-([1,1'-联苯]-4-甲基)-N,N-二甲基-1H-四氮唑-1-甲酰胺,LY 2183240; LY-2183240
A potent, competitive inhibitor of anandamide uptake
GC10629 KN-93
N-[2-[N-(4-氯肉桂)-N-甲基氨基]苯基]-N-(2-羟乙基)-4-甲氧苯磺酰胺磷酸酯盐,KN 93;KN93
Selective inhibitor of Ca²⁺/calmodulin-dependent kinase type II
GC16981 KN-92 phosphate
KN-92磷酸盐,KN 92 phosphate;KN92 phosphate
KN-92 phosphate 是 KN-93 的无活性衍生物，没有 CaM 激酶抑制活性。 KN-92 磷酸盐旨在用作旨在阐明 KN-93 拮抗剂活性的研究中的对照化合物。 KN-93 是一种细胞渗透性、可逆性和竞争性 CaMKII 抑制剂。
GC15988 KN-92 hydrochloride
KN-92盐酸盐,KN 92 hydrochloride;KN92 hydrochloride
An inactive control compound for a CaMKII inhibitor
GC14132 KN-92
KN 92;KN92
An inactive control compound for a CaMKII inhibitor
GC15684 KB-R7943 mesylate
KB-R7943甲磺酰酸盐,KB-R7943; KB-R 7943
An inhibitor of the reverse Na⁺/Ca²⁺ exchanger
GC15730 Kaempferide
山奈素; Kaempferol 4'-O-methyl ether
A flavonoid with diverse biological activities
GC13316 Ivacaftor hydrate
VX-770 hydrate;VX 770 hydrate;VX770 hydrate;Kalydeco hydrate
A CFTR potentiator
GC12489 Ivacaftor benzenesulfonate
VX-770 benzenesulfonate;VX 770 benzenesulfonate;VX770 benzenesulfonate;Kalydeco benzenesulfonate
A CFTR potentiator
GC13795 Isobavachalcone
补骨脂乙素; Corylifolinin; Isobacachalcone
A chalcone and flavonoid with diverse biological activities
GC10939 Hoechst 33342 trihydrochloride
2'-(4-乙氧基苯基)-5-(4-甲基-1-哌嗪基)-2,5'-联-1H-苯并咪唑三盐酸盐,bisBenzimide H 33342;HOE 33342;Hoechst-33342;Hoechst33342

Hoechst 33342 trihydrochloride是一种DNA荧光染料，最大激发/发射光分别为350/460nm。
GC17534 GSK343
GSK-343;GSK 343
A selective, cell-permeable EZH2 inhibitor
GC17450 GSK2606414
GSK 2606414;GSK-2606414
GSK2606414是一种具有口服活性的选择性蛋白激酶R样内质网激酶（PERK）抑制剂，IC₅₀值为0.4nM。
GC16154 GDC-0941 dimethanesulfonate
GDC-0941 (2 MeSO3H salt);GDC0941 dimethanesulfonate;GDC-0941;GDC0941;GDC 0941
A pan inhibitor of class I PI3K isoforms
GC12139 Gambogic Acid
藤黄酸; Beta-Guttiferrin
Gambogic Acid 是一种细胞渗透性 caspase 激活剂和细胞凋亡诱导剂，常用于乳腺癌、肺癌和肝癌等的研究。
GC13535 Fluvastatin
氟伐他汀; XU 62-320 free acid
An HMG-CoA reductase inhibitor
GC16063 Flavopiridol
夫拉平度; HMR-1275; Alvocidib; L86-8275
An inhibitor of cyclin-dependent kinases
GC17143 Fenretinide
芬维A胺; 4-HPR
A synthetic retinoic acid derivative
GC13022 Esomeprazole Magnesium trihydrate
埃索美拉唑镁三水合物; (S)-Omeprazole magnesium trihydrate; (-)-Omeprazole magnesium trihydrate
An H⁺/K⁺-ATPase inhibitor
GC10627 Erlotinib
埃罗替尼; CP-358774; NSC 718781; OSI-774
Erlotinib是一种有效且口服生物可利用的表皮生长因子受体（EGFR）酪氨酸激酶抑制剂，IC₅₀值为2 nM。
GC16044 Emodin
大黄素; Frangula emodin
Natural CK2 inhibitor and ER agonist
GC10466 EMD-1214063
特泊替尼
EMD-1214063（Tepotinib，MSC2156119J）是一种新型强效、高选择性、可逆、ATP 竞争性小分子 c-Met 抑制剂。
GC16073 Dronedarone
决奈达隆; SR 33589
An antiarrhythmic agent
GC13202 D4476
4-[4-(2,3-二氢-1,4-苯并二氧杂环己-6-基)-5-(2-吡啶基)-1H-咪唑-2-基]苯甲酰胺,Casein Kinase I Inhibitor;D 4476;D-4476
Inhibitor of CK1 and ALK5
GC16468 CYT387 sulfate salt
N-(氰基甲基)-4-[2-[[4-(4-吗啉基)苯基]氨基]-4-嘧啶基]苯甲酰胺硫酸盐(1:2),CYT-387 sulfate;CYT 387 sulfate
A potent inhibitor of JAK1 and JAK2
GC14787 Curcumin
姜黄素; Diferuloylmethane; Natural Yellow 3; Turmeric yellow
A yellow pigment with diverse biological activities
GC13261 Colchicine
秋水仙碱
Colchicine（秋水仙碱）是一种可口服的生物碱，通过抑制β-微管蛋白聚合成微管来破坏细胞骨架功能，Colchicine抑制微管的IC₅₀为3 nM。
GC13065 Chelerythrine Chloride
盐酸白屈菜红碱
Potent inhibitor of PKC and Bcl-xL
GC13365 CGI-1746
N-[3-[4,5-二氢-4-甲基-6-[[4-(4-吗啉基羰基)苯基]氨基]-5-氧代-2-吡嗪基]-2-甲基苯基]-4-(叔丁基)苯甲酰胺,CGI1746;CGI 1746
A potent, selective BTK inhibitor
GC14065 Capsaicin
辣椒素; (E)-Capsaicin
辣椒素是一种高度选择性的瞬时受体电位阳离子通道激动剂，亚家族 V，成员 1 (TRPV1)，一种配体门控的非选择性阳离子通道，优先在小直径感觉神经元上表达 < /sup>。
GC12541 Bilobalide
白果内酯; (-)-Bilobalide
A neuroprotective natural product
GC13271 BEZ235 Tosylate
BEZ235对甲苯磺酸盐,NVP-BEZ 235 Tosylate; BEZ-235 Tosylate
BEZ235 Tosylate (BEZ235 Tosylate) 是一种双重 PI3K 和 mTOR 激酶抑制剂，对 PI3Kα, β, γ, δ 的 IC50 值分别为 4, 75, 7, 5 nM。 BEZ235 Tosylate (BEZ235 Tosylate) 抑制 mTORC1 和 mTORC2。
GC10480 Betulinic acid
白桦脂酸; Lupatic acid; Betulic acid
白桦脂酸（Betulinic acid）是一种天然的五环三萜类化合物，是真核细胞拓扑异构酶I的抑制剂，IC₅₀值为5μM。
GC11572 Bardoxolone methyl
甲基巴多索隆; RTA 402; NSC 713200; CDDO Methyl ester
A synthetic triterpenoid with potent anticancer and antidiabetic activity
GC11081 Avermectin B1
阿维菌素 B1; Abamectin; Avermectin B1a-Avermectin B1b mixt.
An insecticide and anthelmintic
GC11106 AT-101
(-)-棉子素,(R)-(-)-Gossypol;R-(-)-gossypol acetic acid;AT 101;AT101
AT-101 (AT-101) 是天然产物棉酚的左旋异构体。 AT-101 与 Bcl-2、Mcl-1 和 Bcl-xL 蛋白结合，Kis 分别为 260±30 nM、170±10 nM 和 480±40 nM。
GC15451 Aliskiren
阿利克仑; CGP 60536; CGP60536B; SPP 100

Aliskiren 是一种具有口服活性的高效选择性肾素抑制剂，IC50 为 1.5 nM。
GC10707 Afatinib dimaleate
双马来酸盐阿法替尼; BIBW 2992MA2
An inhibitor of EGFR and ErbB2
GC15014 A-867744
4-[5-(4-氯苯基)-2-甲基-3-丙酰基吡咯-1-基]苯磺酰胺,A 867744;A867744
A positive allosteric modulator of α7 nAChRs
GC17710 A-317491
A 317491;A317491
A P2X₃ and P2X_2/3 receptor antagonist
GC12791 3,3'-Diindolylmethane
3,3'-二吲哚甲烷,diindolylmethane, 3,3'-Methylenediindole,DIM,Arundine,HB236
A phytochemical with antiradiation and chemopreventative effects
GC12511 Paclitaxel (Taxol)
紫杉醇
紫杉醇是从短叶红豆杉的树皮和针叶中提取出来的三环二萜化合物。
GC11610 Pemetrexed
培美曲塞二钠盐; LY231514 disodium
An antifolate with anticancer activity
GC16966 VER 155008
adenosine-derived inhibitor, VER155008, VER-155008
An Hsp70 inhibitor
GC14308 FK866 (APO866)
达珀利奈; FK866; APO866

Inhibitor of nicotinamide phosphoribosyltransferase
GC10330 Lonafarnib
洛那法尼,Sch 66336, Sch66336, Sch-66336
A farnesyltransferase inhibitor with antitumor activity
GC16984 PF-3845 Inhibitor of FAAH
GC15951 URB597
FAAH Inhibitor II, URB-597, URB 597, KDS-4103
An inhibitor of FAAH