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Home >> Signaling Pathways >> Ubiquitination/ Proteasome

Ubiquitination/ Proteasome(泛素化/蛋白酶体)

  1. Cat.No. 产品名称 Information
  2. GC47735 N-acetyl Desethylchloroquine-d4

    N-acetyl-(mono) Desethylchloroquine

     An internal standard for the quantification of N-acetyl desethylchloroquine
  3. GC47470 Isovaleryl-L-carnitine-d3 (chloride)

    CAR 5:0-d3, C5:0 Carnitine-d3, L-Carnitine isovaleryl ester-d3, L-Isovalerylcarnitine-d3

     A neuropeptide with diverse biological activities
  4. GC47445 Hydroxychloroquine-d4 (sulfate)

    HCQ-d4 sulfate

     An internal standard for the quantification of hydroxychloroquine
  5. GC47436 HT-2 Toxin-13C22

    HT-2毒素-13C22溶液

     An internal standard for the quantification of HT-2 toxin
  6. GC47408 Glycochenodeoxycholic Acid-d4

    甘氨鹅脱氧胆酸-D4,Chenodeoxycholylglycine-d4

     An internal standard for the quantification of glycochenodeoxycholic acid
  7. GC47407 Glycochenodeoxycholic Acid (sodium salt hydrate)

    GCDCA, NSC 681056

     A neuropeptide with diverse biological activities
  8. GC47303 Erlotinib-d6 (hydrochloride)

    埃罗替尼-D6盐酸盐,CP-358774-d6 hydrochloride; NSC 718781-d6 hydrochloride; OSI-774-d6 hydrochloride

     An internal standard for the quantification of erlotinib
  9. GC47284 Elaidic Acid-d17

    C18:1(9E)-d17, 9(E)-Oleic Acid-d17, trans-Oleic Acid-d17

     A neuropeptide with diverse biological activities
  10. GC47271 D-Pyrohomoglutamic Acid

    D-6-氧代哌啶-2-甲酸

     A building block
  11. GC47195 Desethylchloroquine-d4

    N-Desethylchloroquine-d4

     An internal standard for the quantification of desethylchloroquine
  12. GC47194 Desethylchloroquine

    羟基氯喹EP杂质D-d5二盐酸

     An active metabolite of chloroquine
  13. GC47193 Desethyl Hydroxychloroquine-d4

    Desethylhydroxychloroquine-d4

     An internal standard for the quantification of desethyl hydroxychloroquine
  14. GC47065 CAY10773 A derivative of sorafenib
  15. GC47042 Carfilzomib-d8

    来那度胺-D8

     An internal standard for the quantification of carfilzomib
  16. GC47016 Cabergoline-d6

    FCE-21336-d6

     A neuropeptide with diverse biological activities
  17. GC46989 C18 dihydro Ceramide-d3 (d18:0/18:0-d3)

    N-octadecanoyl-D-erythro-Dihydrosphingosine-d3

     An internal standard for the quantification of C18 dihydro ceramide
  18. GC46942 Bortezomib-d15

    LDP-341-d15, MG-341-d15, PS-341-d15

     A neuropeptide with diverse biological activities
  19. GC46923 Bexarotene-d4

    LGD1069 D4

     A neuropeptide with diverse biological activities
  20. GC46897 AUTEN-99

    Autophagy enhancer-99 hydrobromide

     An inhibitor of MRMR14/Jumpy
  21. GC46792 Ac-Nle-Pro-Nle-Asp-AMC (trifluoroacetate salt)

    Ac-Nle-Pro-Nle-Asp-7-amido-4-Methylcoumarin, Ac-nLPnLD-AMC

     A neuropeptide with diverse biological activities
  22. GC61267 SAR439859

    SAR439859

     Amcenestrant (SAR439859, compound 43d) is an orally available and nonsteroidal selective estrogen receptor degrader (SERD) with potential antineoplastic activity. SAR439859 is a potent estrogen receptor (ER) antagonist with EC50 of 0.2 nM for ERα degradation.
  23. GC61263 Salvigenin

    三裂鼠尾草素

     A polyphenol flavonoid with diverse biological activities
  24. GC61256 Rupatadine D4 fumarate

    UR-12592 D4 fumarate

     RupatadineD4fumarate(UR-12592D4fumarate)是Rupatadinefumarate的氘代标记物。RupatadineFumarate(UR-12592Fumarate)富马酸盐是PAF/H1受体双抑制剂，Ki值分别为0.55μM和0.1μM。
  25. GC61251 Rosuvastatin D3

    ZD 4522 D3

     RosuvastatinD3(ZD4522D3)是Rosuvastatin的一种氘代化合物。Rosuvastatin(ZD4522)是一种竞争性HMG-CoA还原酶抑制剂，IC50为11nM。Rosuvastatin有效阻断人类醚-a-go-go相关基因(hERG)电流，IC50为195nM，延迟心脏复极化，从而延长动作电位持续时间(APDs)和校正QT间期(QTc)间隔。
  26. GC61229 Quinacrine dihydrochloride

    阿的平; Mepacrine dihydrochloride; SN-390 dihydrochloride

     Quinacrine 2HCl(Quinacrine dihydrochloride) is a lipophilic cationic drug with multiple actions that is commonly used as an anti-protozoal agent. Quinacrine is an effective phospholipase A2 inhibitor.
  27. GC61227 Quercetin D5

    槲皮素 d5

     QuercetinD5是Quercetin的一种氘代化合物。Quercetin是一种天然黄酮类化合物，可激活或抑制许多蛋白质的活性。Quercetin可激活SIRT1，也可抑制PI3K，抑制PI3Kγ，PI3Kδ，PI3Kβ的IC50分别为2.4μM,3.0μM,5.4μM。
  28. GC61221 PTP1B-IN-9

    NSC 638643

     An inhibitor of the ubiquitin-proteasome system
  29. GC61183 Physalin B

    酸浆苦味B

     PhysalinB是Capegooseberry中主要的甾体活性成分之一，通过调节p53依赖的凋亡途径，诱导乳腺癌细胞周期阻滞和诱导凋亡(apoptosis)。PhysalinB抑制人结肠癌细胞泛素-蛋白酶体通路并诱导不完全自噬反应。
  30. GC61155 Omeprazole sodium

    奥美拉唑钠,H 16868 sodium

     An irreversible inhibitor of the gastric proton pump
  31. GC61093 MSAB MSAB is a selective inhibitor of Wnt/β-catenin signaling that binds to β-catenin, promoting its degradation, and specifically downregulates Wnt/β-catenin target genes. MSAB shows potent anti-tumor effects.
  32. GC61045 Metformin D6 hydrochloride

    二甲双胍盐酸,1,1-Dimethylbiguanide-d6 hydrochloride

     An internal standard for the quantification of metformin
  33. GC61003 Loperamide D6 hydrochloride

    4-[4-(4-氯苯基)-4-羟基哌啶-1-基]-2,2-二苯基-N,N-二(三氘甲基)丁酰胺盐酸盐,R-18553-d6 hydrochloride

     LoperamideD6hydrochloride(R-18553D6hydrochloride)是Loperamidehydrochloride的氘代化合物。Loperamidehydrochloride是一种阿片受体(opioidreceptor)的激动剂，可用于腹泻的研究。
  34. GC60935 Indomethacin sodium hydrate

    吲哚美辛钠盐三水合物; Indometacin sodium hydrate

     A non-selective COX inhibitor
  35. GC60930 Imatinib D4

    [2H4]-伊马替尼,STI571 D4; CGP-57148B D4

     ImatinibD4(STI571D4)是Imatinib(STI571)的氘代物。Imatinib是一种口服生物可用的酪氨酸激酶抑制剂，可选择性抑制BCR/ABL，v-Abl，PDGFR，c-kit激酶活性。
  36. GC60891 GW406108X

    GW108X

     GW406108X (GW108X) is an inhibitor of Kif15 (Kinesin-12) with an IC50 of 0.82 μM in the ATPase assay. GW406108X inhibits recombinant ULK1 kinase activity with a pIC50 of 6.37 and blocks autophagy in cells, without affecting the upstream signalling kinases mTORC1 and AMPK.
  37. GC60882 Glyphosate

    草甘膦

     An herbicide
  38. GC60868 Gefitinib D8

    吉非替尼杂质-D8,ZD1839-d8

     GefitinibD8(ZD1839D8)是Gefitinib的氘代物。Gefitinib是一种有效的(EGFR)抑制剂，在NR6wtEGFR细胞中IC50值为2-37nM。
  39. GC60826 Etoposide phosphate

    磷酸依托泊苷; BMY-40481

     Etoposidephosphate(BMY-40481)是一种有效的抗癌(anti-cancer)化疗试剂和一种选择性拓扑异构酶II(topoisomeraseII)抑制剂，可以防止DNA链的重新连接。Etoposidephosphate是依托泊苷的磷酸酯前药，被认为与Etoposide活性相当。Etoposidephosphate诱导细胞周期阻滞、凋亡(apoptosis)和自噬(autophagy)。
  40. GC60700 Chloroquine D5

    氯喹 d5

     An internal standard for the quantification of chloroquine
  41. GC60688 Cereblon modulator 1

    CC-90009

     A modulator of cereblon
  42. GC60668 Calcimycin hemimagnesium

    CALIMYCIN半镁盐,A-23187 hemimagnesium; Antibiotic A-23187 hemimagnesium

     Calcimycin(A-23187)hemimagnesium是一种抗生素和独特的二价阳离子离子载体(divalentcationionophore)，如钙离子和镁离子。Calcimycinhemimagnesium通过增加细胞内钙浓度诱导Ca2+依赖性细胞死亡。Calcimycinhemimagnesium抑制革兰氏阳性细菌和一些真菌的生长，还抑制ATP酶的活性并解耦哺乳动物细胞的氧化磷酸化(OXPHOS)，诱导细胞凋亡(apoptosis)。
  43. GC60567 Afatinib impurity 11 Afatinib impurity 11 is an impurity of afatinib, an EGFR family inhibitor.
  44. GC60395 (3S,5R)-Fluvastatin D6

    (3S,5R)-XU 62-320 free acid D6

     (3S,5R)-FluvastatinD6是(3S,5R)-Fluvastatinsodium的氘代物。Fluvastatin是第一个完全合成的，竞争性的HMG-CoAreductase还原酶抑制剂，IC50为8nM。Fluvastatin通过依赖Nrf2的抗氧化通路保护血管平滑肌细胞免受氧化应激。
  45. GC60325 Rilmenidine

    利美尼啶

     An antihypertensive agent
  46. GC60257 MSC1094308 MSC1094308 是一种可逆的、II 型 AAA ATPase (VCP)/p97 和I型 AAA ATPase VPS4B 的变构抑制剂，对VPS4B 和 p97 的IC50 值分别为 0.71 μM 和 7.2 μM。
  47. GC60245 Metformin

    二甲双胍; 1,1-Dimethylbiguanide

     二甲双胍（1,1-二甲基双胍）主要介导 AMPK 的激活，AMPK 是一种参与调节细胞能量代谢的丝氨酸/苏氨酸蛋白激酶，可导致癌细胞中 mTOR 信号传导和蛋白质合成的减少。
  48. GC60241 Melatonin D5

    褪黑素 D5; N-Acetyl-5-methoxytryptamine-d4

     An internal standard for the quantification of melatonin
  49. GC60159 Ezetimibe ketone

    (3R,4S)-1-(4-氟苯基)-3-[3-(4-氟苯基)-3-氧代丙基]-4-(4-羟基苯基)氮杂环丁烷-2-酮,EZM-K

     Ezetimibe ketone (EZM-K) 是 Ezetimibe 的 I 期代谢产物。Ezetimibe 是一种 NPC1L1 抑制剂，是有效的 Nrf2 激活剂，Ezetimibe 还是有效的胆固醇吸收抑制剂。
  50. GC60076 Bigelovin

    锦菊素

     Bigelovin是可从海百合中分离得到的一种倍半萜内酯，是选择性的视黄素X受体α(retinoidXreceptorα)的激动剂。Bigelovin可通过诱导凋亡和自噬来发挥抗肿瘤活性。Bigelovin通过抑制ROS的生成来调节mTOR信号通路。
  51. GC39708 DT2216 DT2216 是一种蛋白水解靶向嵌合体 (PROTAC)，靶向 Bcl-xL 降解依赖于 Bcl-2 家族过表达蛋白（例如 Bcl-2、Bcl-xL 和 Mcl）的 T 细胞淋巴瘤-1.DT2216 抑制 G-68 细胞，IC50 值为 4.02 μM（72 小时）。

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