Ubiquitination/ Proteasome(泛素化/蛋白酶体)

Cat.No. 产品名称 Information

GC39658 4,4'-Dimethoxychalcone

4,4'-甲氧基查耳酮

4,4'-Dimethoxychalcone 可从植物当归中分离得到，是一种天然自噬 (autophagy) 诱导剂，具有抗衰老活性。

GC39612 Imatinib D8

伊马替尼D8,STI571-d8; CGP-57148B-d8

Imatinib D8 (STI571 D8) 是 Imatinib (STI571) 的氘代物。Imatinib 是一种口服生物可用的酪氨酸激酶抑制剂，可选择性抑制 BCR/ABL，v-Abl，PDGFR，c-kit 激酶活性。

GC39530 TFEB activator 1

(1E,4E)-1,5-二(2-甲氧基)-1,4-二烯基-3-戊酮,Curcumin analog C1

A synthetic curcuminoid and activator of TFEB

GC39481 BL-918 An ULK1 activator

GC39450 Tea polyphenol

茶多酚

Tea polyphenols are chemical compounds such as flavanoids and tannins found naturally in tea. Several biological properties have been associated to tea polyphenols (TP), including antioxidant, anti-carcinogenic and antimicrobial activities.

GC39411 NL-1 The mitochondrial mitoNEET ligand NL-1 is a mitoNEET inhibitor, which induces a concentration-dependent decrease in cell viability with an IC50 of 47.35 μM and 56.26 μM in REH and REH/Ara-C cells respectively. The docking studies using liver mitochondrial suspensions show the IC50 of NL-1 binding for [3H]-rosiglitazone is 0.9 μM and the Ki for NL-1 site 1 and site 2 was 4.78 and 2.77, respectively.

GC39407 MS1943 A PROTAC that drives EZH2 degradation

GC39395 LC3-mHTT-IN-AN1 An LC3B-mutant huntingtin linker

GC39372 Desethyl chloroquine diphosphate

脱乙基氯喹二磷酸盐

Desethyl chloroquine diphosphate 是 Chloroquine 的主要去乙基代谢产物。Chloroquine 是一种自噬和 toll-like receptors (TLRs) 的抑制剂。Desethyl chloroquine diphosphate 具有抗疟原虫活性。

GC50305 Autocamtide-2-related inhibitory peptide, myristoylated Autocamtide-2 相关抑制肽，肉豆蔻酰化是肉豆蔻酰化 Autocamtide-2 相关抑制肽。

GC50253 PF 543 hydrochloride

Sphingosine Kinase 1 Inhibitor II hydrochloride

A potent inhibitor of SPHK1

GC50234 N106

N-(4-甲氧基苯并[D]噻唑-2-基)-5-(4-甲氧基苯基)-1,3,4-噁二唑-2-胺

An activator of SERCA2A sumoylation

GC50113 Noradrenaline bitartrate

L-去甲肾上腺素酒石酸氢盐(酯),Levarterenol tartrate; L-Noradrenaline tartrate

Norepinephrine (Levarterenol; L-Noradrenaline) tartrate 是一种有效的肾上腺素能受体 (AR) 激动剂。

GC50067 ML 3403

ML 3403 是一种有效的 p38 MAPK 抑制剂，IC50 为 0.38 μM。

GC50040 SCIO 469 hydrochloride A p38 MAPK inhibitor

GC50009 LY 294002 hydrochloride Prototypical PI 3-kinase inhibitor; also inhibits other kinases

GC39318 DSHS00884

SSYA10-001

DSHS00884 是有效的人乳头瘤病毒 E6 抑制剂，IC50 为 10 μM。

GC39313 LC3-mHTT-IN-AN2

5,7-二羟基-4-苯基香豆素

LC3-mHTT-IN-AN2 (Compound AN2) 是一种 mHTT-LC3 连接化合物，LC3-mHTT-IN-AN2 与突变型亨廷顿蛋白 (mHTT) 和 LC3B 相互作用，但不与 wtHTT 或无关的对照蛋白相互作用。LC3-mHTT-IN-AN2 以等位基因选择性的方式降低了亨廷顿病 (HD) 小鼠神经元中mHTT水平。

GC39305 EACC EACC 是可逆的自噬 (autophagy) 抑制剂，可阻断自噬通量。EACC 选择性抑制自噬体特异性的 SNARE Stx17 的易位，从而阻止自噬体与溶酶体的融合。

GC39260 OR-1855

(R)-6-(4-氨基苯基)-4,5-二氢-5-甲基-3(2H)-哒嗪酮

OR-1855 是 Levosimendan 的活性代谢产物，对人体肌层收缩力有影响。Levosimendan 是一种钙敏感性药物，用于治疗急性失代偿性充血性心力衰竭。

GC46057 2,5-Dihydroxycinnamic Acid phenethyl ester An inhibitor of 5-LO

GC39166 TCH-165 TCH-165 是蛋白酶体组装的小分子调节剂，可增加 20S 水平并促进 20S 介导的蛋白质降解。

GC39109 Isodeoxyelephantopin

异去氧苦地胆苦素

Isodeoxyelephantopin 是一种倍半萜烯内酯，可从Elephantopus scaber 中分离得到。Isodeoxyelephantopin 可诱导活性氧的生成，抑制NF-κB 的激活。Isodeoxyelephantopin 还能调节LncRNA 的表达，有抗乳腺癌的作用。

GC39023 Notoginsenoside Fc

三七皂苷 FC

Notoginsenoside Fc 是从三七叶中分离得到的一种原卟啉二醇 (PPD-) 型皂苷，可有效抵消血小板聚集。Notoginsenoside Fc 可以通过促进自噬促进糖尿病大鼠血管损伤后的内皮细胞再生。

GC46008 (±)-Thalidomide-d4

沙利度胺 D4

An internal standard for the quantification of (±)-thalidomide

GC45885 Chloroquine-d5 (phosphate)

磷酸氯喹 d5 (二磷酸盐)

An internal standard for the quantification of chloroquine

GC45828 Ponatinib-d8

纳替尼-D8,AP24534-d8

An internal standard for the quantification of ponatinib

GC45719 Gymnemic Acid I

匙羹藤酸I

A triterpene glycoside

GC45639 Hexapeptide-11 (acetate)

FVAPFP, Phe-Val-Ala-Pro-Phe-Pro

A synthetic hexapeptide

GC45616 C6 Urea Ceramide

C6 Ceramide (d18:1/6:0) Urea, Cer(d18:1/6:0) Urea, D-erythro-Urea-C6-Ceramide

An inhibitor of neutral ceramidase

GC38629 Calcineurin substrate (TFA) Calcineurin substrate (TFA) 是来自 cAMP 依赖性蛋白激酶调节性RII亚基的多肽。Calcineurin substrate (TFA) 可用于钙调神经磷酸酶活力的测定。

GC38564 Deoxypodophyllotoxin

脱氧鬼臼毒素

A flavolignan with diverse biological activities

GC38562 P62-mediated mitophagy inducer

PMI

P62-mediated mitophagy inducer 是一种线粒体自噬调节剂，能激活线粒体噬但不招募 Parkin 或者使膜电位崩溃，且在缺乏完整功能的 PINK1/Parkin 通路的细胞中保留活性。

GC38528 Dehydropachymic acid

去氢茯苓酸

Dehydropachymic acid 是从茯苓 (Poria cocos) 中分离出的主要三萜类化合物之一。Dehydropachymic acid 在自噬-溶酶体途径 (ALP) 受损细胞比正常细胞中更有效。

GC38451 S29434

NMDPEF

S29434 (NMDPEF) 是一种有效、竞争性、选择性、可透过细胞膜的醌还原酶 2 (quinone reductase 2 (QR2)) 抑制剂，在不同的组织层面，对人 QR2 的 IC50 值为 5-16 nM，对其选择性高于 QR1。S29434 (NMDPEF) 可诱导自噬 (autophagy)，抑制 QR2 介导的 ROS 的产生。

GC38437 Fangchinoline

防己诺林碱

An alkaloid with diverse biological activities

GC38419 Cyclovirobuxine D

黄杨碱

An alkaloid with diverse biological activities

GC38408 Diosgenin glucoside

延龄草苷

A steroidal saponin with diverse biological activities

GC38401 rac-AZD 6482

2-[[1-[7-甲基-2-(吗啉-4-基)-4-氧代-4H-吡啶并[1,2-A]嘧啶-9-基]乙基]氨基]苯甲酸,(Rac)-KIN-193

rac-AZD 6482 (rac-KIN-193) 是 AZD 6482 的低活性外消旋体，AZD 6482 是一种有效的选择性 p110β 抑制剂，IC50 为 0.69 nM。

GC38150 Liensinine Diperchlorate

莲心碱高氯酸盐

Liensinine, a major isoquinoline alkaloid, inhibits late-stage autophagy/mitophagy through blocking autophagosome-lysosome fusion. It is a novel autophagy/mitophagy inhibitor.

GA23841 Z-Ile-Glu(OtBu)-Ala-Leu-aldehyde

Z-异亮氨酰-叔丁基谷氨酰-丙氨酸-亮氨酸缩醛,Proteasome Inhibitor 1

Z-IE(OtBu)AL-CHO is an inhibitor of chymotrypsin-like activity of the multicatalytic proteinase complex (MPC; 20S proteasome) in HT4 cells. It is the first inhibitor reported so far which can cause accumulation of ubiquitinylated proteins in neuronal cells. Furthermore, this compound induced massive apoptosis in murine leukaemia L1210 cells. Therefore, proteasome inhibitors may be considered as potential anti-neoplastic agents.