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Home >> Signaling Pathways >> Ubiquitination/ Proteasome

Ubiquitination/ Proteasome(泛素化/蛋白酶体)

  1. Cat.No. 产品名称 Information
  2. GC35832 Dehydrocorydaline chloride

    盐酸脱氢紫堇碱; 13-Methylpalmatine chloride

     An alkaloid with diverse biological activities
  3. GC35820 DDD107498 succinate

    DDD107498 succinate; DDD-498 succinate; M5717 succinate

     DDD107498 (M-5717, DDD-498) is a P. falciparum translation elongation factor 2 inhibitor. DDD107498 exhibits a potent and novel spectrum of antimalarial activity against multiple life-cycle stages of the Plasmodium parasite.
  4. GC35812 Dasatinib hydrochloride

    达沙替尼盐酸盐; BMS-354825 hydrochloride

     An inhibitor of Abl and Src
  5. GC35668 CG-200745

    CG-200745

     CG-200745 (CG-200745) 是一种具有口服活性的强效 pan-HDAC 抑制剂，其异羟肟酸部分可与催化袋底部的锌结合。 CG-200745 抑制组蛋白 H3 和微管蛋白的去乙酰化。 CG-200745 诱导 p53 的积累，促进 p53 依赖性反式激活，并增强 MDM2 和 p21 (Waf1/Cip1) 蛋白的表达。 CG-200745 增强了吉西他滨耐药细胞对吉西他滨和 5-氟尿嘧啶 (5-FU;) 的敏感性。 CG-200745 诱导细胞凋亡并具有抗肿瘤作用。
  6. GC35667 CFTR corrector 1

    VX-445

     An F508del-CFTR corrector and potentiator
  7. GC35613 Carvedilol phosphate hemihydrate

    卡维地洛磷酸盐,BM 14190 phosphate hemihydrate

     A β-adrenergic receptor antagonist
  8. GC35601 CaMKII-IN-1

    3-氯-2-甲基-N-[5,6,7,8-四氢-2-[(2-苯基乙基)氨基]-6-(苯基甲基)吡啶并[4,3-D]嘧啶-4-基]苯磺酰胺

     CaMKII-IN-1是CaMKII高效选择性抑制剂，IC50值为63nM,对CaMKIV, MLCK, p38a, Akt1,和PKC几乎无作用。
  9. GC35555 Britannin

    旋覆花内酯

     Britannin，分离于 Inula aucheriana，是倍半萜内酯。Britannin 通过激活由 ROS 调节的 AMPK 来诱导肝癌细胞凋亡和自噬。Britannin 具有抗增殖和抗炎活性。
  10. GC35554 Brevilin A

    短叶老鹳草素A

     A sesquiterpene lactone with anticancer activity
  11. GC35509 BGT226

    NVP-BGT226

     BGT226 (NVP-BGT226) maleate is a novel class I PI3K/mTOR inhibitor for PI3Kα/β/γ with IC50 of 4 nM/63 nM/38 nM. Phase 1/2.
  12. GC35497 Berberine chloride hydrate

    盐酸黄连素水合物; Natural Yellow 18 chloride hydrate

     As isoquinoline alkaloid with diverse biological activities
  13. GC35462 Bafetinib

    巴氟替尼; INNO-406; NS-187

     A Bcr-Abl inhibitor
  14. GC35445 Azathramycin

    去甲基阿奇霉素; Azaerythromycin A; Desmethyl Azithromycin

     Azathramycin (Azaerythromycin A, Azaerythromycin) is a macrolide antibiotic containing cladinose.
  15. GC35434 Autogramin-2 Autogramin-2 有效抑制由饥饿诱导的自噬 (autophagy)，IC50 为 0.27 μM。Autogramin-2 也抑制 Rapamycin (通过抑制 mTORC1) 诱导的自噬 (autophagy)，IC50 为 0.14 μM。
  16. GC35433 Autogramin-1 Autogramin-1 有效抑制由饥饿诱导的自噬 (autophagy)，IC50 为 0.17 μM。Autogramin-1 也抑制 Rapamycin (通过抑制 mTORC1) 诱导的自噬 (autophagy)，IC50 为 0.44 μM。
  17. GC35432 Autocamtide-2-related inhibitory peptide (TFA) A CaMKII inhibitor
  18. GC35419 Atorvastatin

    阿托伐他汀

    阿托伐他汀（Atorvastatin）是一种口服活性HMG-CoA还原酶抑制剂，可以有效降低血脂
  19. GC35322 Amiodarone

    胺碘酮

     Amiodarone (NSC 85442,Amiodar,Amiodarone hydrochloride,Nexterone) HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias.
  20. GC35268 AGN 205728 AGN 205728是选择性RARγ拮抗剂，Ki/IC95分别为3 nM/ 0.6 nM，对RARα和RARβ无抑制性。
  21. GC35267 AGN 205327 AGN 205327是RAR激动剂，对RARα/β/γ的EC50分别为3766/734/32 nM，对RXR无抑制性。
  22. GC35266 AGN 196996 AGN 196996是高活性RARα选择性抑制剂，Ki为2 nM，对RARβ和RARγ的亲和性极低（Ki分别为1087 nM和8523 nM）。
  23. GC35265 AGN 195183

    IRX-5183; VTP-195183; NRX-195183

     AGN 195183是RARα选择性激动剂，Kd为3 nM，相对于AGN 193836有更好的结合选择性，对RARβ/γ无活性。
  24. GC35262 Afzelin

    阿福豆苷,Kaempferol-3-O-rhamnoside

     A polyphenolic glycoside flavone with diverse biological activities
  25. GC35242 Actein

    黄肉楠碱

     Actein 是从 Cimicifuga foetida 的根茎中分离的三萜糖苷。Actein 通过促进 ROS/JNK 活化和钝化人膀胱癌中的 AKT 途径来抑制细胞增殖，诱导自噬和凋亡。Actein 在体内几乎没有毒性。
  26. GC35238 Aclacinomycin A hydrochloride

    盐酸阿柔比星; Aclarubicin hydrochloride

     Aclacinomycin A hydrochloride (Aclarubicin hydrochloride) 是一种荧光分子，是第一个发现对 20S 蛋白酶体 (20S proteasome) 的CTRL (糜凝乳蛋白酶样) 活性具有离散特异性的非肽性抑制剂。同时也是 拓扑异构酶 I 和 II (topoisomerase I and II) 的双抑制剂。是一种有效治疗血癌和实体肿瘤的蒽环类化疗药物。
  27. GC35228 Aceglutamide

    乙酰谷酰胺; α-N-Acetyl-L-glutamine; N2-Acetylglutamine

     An acetylated form of L-glutamine
  28. GC35211 A-317491 sodium salt hydrate A P2X3 and P2X2/3 receptor antagonist
  29. GC35132 4-Hydroxylonchocarpin

    异补骨脂色烯查耳酮

     4-Hydroxylonchocarpin 是一种查尔酮化合物，来自补骨脂 (Psoralea corylifolia) 提取物。4-Hydroxylonchocarpin 增强 p38 MAPK，JNK 和 ERK 的磷酸化。4-Hydroxylonchocarpin 具有多种药理活性，包括抗菌，抗癌，抗逆转录酶，抗结核，抗疟，抗炎和抗氧化活性。
  30. GC35112 3'-Hydroxypterostilbene

    3’-羟基紫檀茋

     3'-Hydroxypterostilbene (3'-HPT) is one of the active constituents of Sphaerophysa salsula and Pterocarpus marsupium which may be useful in treating different types of haematological malignancies. 3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells (IC50s of 9.0, 40.2, and 70.9 ?M for COLO 205, HCT-116, and HT-29 cells, respectively) by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene inhibits the PI3K/Akt/mTOR/p70S6K, and p38MAPK pathways and activates the ERK1/2, JNK1/2 MAPK pathways.
  31. GC35068 1-Monomyristin

    1-肉豆蔻酸单甘油酯

     A monoacylglycerol
  32. GC34960 (+)-Talarozole (+)-Talarozole 是视黄酸代谢的有效抑制剂，来自专利 WO 1997049704 A1。
  33. GC45187 Zoledronic Acid (hydrate)

    唑来膦酸一水合物; Zoledronate monohydrate; CGP 42446 monohydrate; CGP42446A monohydrate; ZOL 446 monohydrate

     A bisphosphonate that inhibits bone resorption
  34. GC45185 Z-LLL-AMC

    Z-Leu-Leu-Leu-AMC, Z-Leu-Leu-Leu-7-amido-4-Methylcoumarin, Proteasome Substrate I

     A fluorogenic substrate for proteasomal chymotrypsin-like activity
  35. GC45184 Z-LLE-AMC

    N-[(苯基甲氧基)羰基]-L-亮氨酰-L-亮氨酰-N-(4-甲基-2-氧代-2H-1-苯并吡喃-7-基)-L-ALPHA-谷氨酰胺

     A fluorogenic substrate for proteasomal caspase-like activity
  36. GC45099 U-0126

    1,4-二氨基-2,3-二氰基-1,4-双(邻氨基苯巯基)丁二烯

    A MEK inhibitor and AMPK activator
  37. GC45064 Tomatidine (hydrochloride)

    盐酸番茄碱

     A steroidal alkaloid with diverse biological activities
  38. GC44963 Suc-Leu-Tyr-AMC

    N-琥珀酰基-亮氨酰-酪氨酸-7-胺基-4-甲基香豆素

     A calpain and papain substrate
  39. GC44856 Rutin (hydrate)

    芦丁三水合物; Rutoside trihydrate; Quercetin 3-O-rutinoside trihydrate

     A flavonoid glycoside with diverse biological activities
  40. GC44839 Ridaifen-B An analog of tamoxifen
  41. GC44797 Quinacrine analog 34 An autophagy inhibitor
  42. GC44680 Pregnenolone sulfate (sodium salt)

    3β-Hydroxy-5-pregnen-20-one monosulfate sodium

     A metabolite of pregnenolone
  43. GC44464 NSC 109555

    DDUG, NCI C04808

     An inhibitor of Chk2
  44. GC44400 Niclosamide (ethanolamine salt)

    氯硝柳胺乙醇胺盐,BAY2353 olamine

     氯硝柳胺是一种经美国食品和药物管理局 (FDA) 批准用于治疗肠道蛔虫感染的驱虫药。
  45. GC44346 N-Desethylamiodarone (hydrochloride)

    去乙基胺碘酮,N-desethylamiodarone hydrochloride; LB 33020 hydrochloride

     A CYP3A4 metabolite of amiodarone
  46. GC44291 NAB 2 An inhibitor of α-synuclein-induced toxicity
  47. GC44290 NAADP (sodium salt)

    Nicotinic acid adenine dinucleotide phosphate

    A secondary messenger that induces calcium mobilization
  48. GC44059 LG 100268

    6-[1-(5,6,7,8-四氢-3,5,5,8,8-五甲基-2-萘基)环丙基]-3-吡啶羧酸,LG268

     An RXR agonist
  49. GC43999 Ketanserin (tartrate)

    酒石酸酮色林,R41468 tartrate

     A potent 5-HT2 receptor antagonist
  50. GC43922 Isovaleryl-L-carnitine (chloride)

    L-异戊酰基肉碱

     An acylcarnitine
  51. GC43599 Emetine (hydrochloride)

    盐酸吐根碱

     An alkaloid with diverse biological activities

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