Ubiquitination/ Proteasome(泛素化/蛋白酶体)

Cat.No. 产品名称 Information

GC43359 Cytochalasin E

细胞松弛素E

Inhibitor of actin polymerization

GC43354 Cysmethynil

Icmt Inhibitor

An inhibitor of protein prenylation

GC43321 CPTH6 (hydrobromide) A Gcn5 and pCAF HAT inhibitor

GC43265 Chromomycin A2

色霉素A2

An antibacterial and anticancer aureolic acid

GC43189 CAY10681 A dual modulator of p53-MDM2 interaction and NF-κB signaling

GC43144 Carfilzomib Impurity 13 (hydrochloride) A potential impurity found in commercial carfilzomib preparations

GC43105 C8 Ceramide (d18:1.8:0)

N-辛酰基-D-神经鞘氨醇; N-Octanoyl-D-erythro-sphingosine

A cell-permeable ceramide analog

GC43048 C18 dihydro Ceramide (d18:0/18:0)

二羟基神经酰胺,Cer(d18:0/18:0)

A bioactive sphingolipid

GC42958 Boc-LRR-AMC

Boc-Leu-Arg-Arg-AMC, Boc-Leu-Arg-Arg-7-amido-4-Methylcoumarin

A fluorogenic substrate for trypsin-like activity of the 26S proteasome or 20S proteolytic core

GC42720 Ac-WLA-AMC

Acetyl-Trp-Leu-Ala-7-amino-4-Methylcoumarin, Ac-Trp-Leu-Ala-AMC

A fluorogenic substrate for the 20S proteasome

GC42712 Ac-RLR-AMC (trifluoroacetate salt)

Ac-Arg-Leu-Arg-AMC, Ac-Arg-Leu-Arg-7-amino-4-Methylcoumarin

A fluorogenic substrate for the 26S proteasome

GC42710 Ac-PAL-AMC

Acetyl-Pro-Ala-Leu-7-amino-4-Methylcoumarin, Ac-Pro-Ala-Leu-AMC

A fluorogenic substrate for the 20S proteasome

GC42685 Ac-ANW-AMC

Ac-Ala-Asn-Trp-AMC

A fluorogenic substrate for the 20S immunoproteasome

GC42677 ABO (hydrochloride) A modulator of annexin A7

GC42414 4-hydroxy Tolbutamide

4-羟基甲苯磺丁脲,Hydroxytolbutamide

A CYP2C8 and CYP2C9 metabolite of tolbutamide

GC41625 Oroxylin A

千层纸素A; Baicalein 6-methyl ether; 6-Methoxybaicalein

A flavonoid with diverse biological activities

GC41308 GPP 78

CAY10618

Inhibitor of Nampt

GC41242 Acridine Orange

吖啶橙,NSC 194350

Acridine Orange是一种可穿透细胞的核酸选择性荧光染料。

GC41233 (R)-MG132

N-[(苯基甲氧基)羰基]-L-亮氨酰-N-[(1S)-1-甲酰基-3-甲基丁基]-D-亮氨酰胺,(S,R,S)-(-)-MG-132; Z-Leu-D-Leu-Leu-al

(R)-MG132是一种蛋白酶体抑制剂，IC₅₀为100 nM。

GC40947 2,3-Dimethoxy-5-methyl-p-benzoquinone

2,3-二甲氧基-5-甲基-1,4-苯醌,CoQ0

An intermediate in the synthesis of ubiquinones that has anticancer activity

GC40911 Glycine-β-muricholic Acid

Gly-MCA, GβMCA

An intestine-selective FXR antagonist

GC40861 Pinosylvin

赤松素

A stilbene with diverse biological activities

GC40793 L-erythro Sphinganine (d18:0)

L-苏式-二氢鞘胺醇

A bioactive sphingolipid

GC40792 D-threo Sphinganine (d18:0)

D-苏式二氢鞘氨醇

A bioactive sphingolipid

GC40775 Dexamethasone

地塞米松; Hexadecadrol; Prednisolone F

地塞米松是糖皮质激素家族的一员，可以保护软骨结构和功能免受关节炎相关变化的影响，包括基质丢失、炎症和软骨活力。

GC40769 Asperphenamate

Anabellamide, Auranamide, NSC 306231

A fungal secondary metabolite

GC40694 Calpain Inhibitor II

Calpain inhibitor II

A non-selective cysteine protease inhibitor

GC40685 Pentoxifylline

NSC 637086, Oxpentifylline

Pentoxifylline is a methylxanthine derivative.

GC40484 Ferulic Acid methyl ester

阿魏酸甲酯; Methyl ferulate

A lipophilic antioxidant

GC34924 NSC 185058 An inhibitor of ATG4B

GC34918 MW-150 dihydrochloride dihydrate

MW01-18-150SRM dihydrochloride dihydrate

An inhibitor of p38α MAPK

GC34862 WYC-209

4,5-二(羟甲基)-2-苯基-1H-咪唑

WYC-209是一种合成类视黄醇，能抑制恶性小鼠黑色素瘤肿瘤再生细胞(TRC)的增殖，IC50值为0.19μM。WYC-209主要细胞靶点是维甲酸受体(RARs)。

GC34849 UBCS039 UBCS039 is the first synthetic SIRT6 activator with EC50 of 38 μM,induces a time-dependent activation of autophagy in several human tumor cell lines.

GC34817 Sulfosuccinimidyl oleate sodium

SSO

An irreversible inhibitor of CD36

GC34745 PTI-428

PTI-428

Nesolicaftor (PTI-428) is a specific cystic fibrosis transmembrane conductance regulator (CFTR) amplifier that increases CFTR expression.

GC34686 Nidufexor

LMB763

An FXR partial agonist

GC34649 LMP7-IN-1 LMP7-IN-1 是一种可口服的、有效的、可逆的和高度选择性的免疫蛋白酶体亚基 LMP7 (β5i) 抑制剂。 LMP7-IN-1 对 LMP7 亚基具有高生化 (IC50=3.6 nM) 和细胞 (IC50=3.4 nM) 效力。 LMP7-IN-1 在多发性骨髓瘤异种移植模型中显示出强大的抗肿瘤功效。 LMP7-IN-1 可显着长期抑制肿瘤 LMP7 活性和泛素化蛋白转换，并诱导多发性骨髓瘤细胞凋亡。

GC34532 CFTR corrector 2 FDL169 is a CFTR corrector that is designed to fix and restore the function of the defective CFTR protein.

GC40227 Indomethacin-d4

吲哚美辛-D4; Indometacin-d4

An internal standard for the quantification of indomethacin

GC40226 Curcumin-d6

(1E,4Z,6E)-5-羟基-1,7-二[4-羟基-3-(甲氧基-D3)苯基]-1,4,6-庚三烯-3-酮,Diferuloylmethane-d6; Natural Yellow 3-d6; Turmeric yellow-d6

An internal standard for the quantification of curcumin

GC40218 (-)-Epigallocatechin Gallate-d3/d4

EGCG-d3/d4

An internal standard for the quantification of (–)-epigallocatechin gallate

GC40080 Bosutinib-d8

SKI-606 D8

An internal standard for the quantification of bosutinib

GC40065 Meloxicam-d3

美洛昔康 d3

An internal standard for the quantification of meloxicam

GC40044 Zymostenol

Δ8-Cholesterol

A precursor of cholesterol

GC40007 Malformin A

Malformin A1

A cyclopentapeptide fungal metabolite with diverse biological activities

GC34390 Autocamtide 2, amide Autocamtide2,amide是钙调蛋白激酶(CaMK)家族实验的底物(100μMfinalconcentration)。

GC34330 XRK3F2 XRK3F2 is an inhibitor of the p62-ZZ domain that blunts MM-induced Runx2 suppression in vitro, and induces new bone formation and remodeling in the presence of tumor in vivo.

GC34315 ULK-101 ULK-101 is a potent and selective ULK1 inhibitor with IC50 values of 8.3 nM and 30 nM for ULK1 and ULK2, respectively.

GC34173 LG-100064

4-[(5,6,7,8-四氢-3,5,5,8,8-五甲基-2-萘基)羰基]苯甲酸

LG-100064是一种类视黄醇X受体(retinoid-X-receptor(RXR))激动剂，对RXRα，RXRβ和RXRγ的EC50值分别为330nM，200nM和260nM；LG-100064可用于癌症研究。

GC34117 SMER18 SMER18是Rapamycin的一种小分子增强剂,充当mTOR非依赖性的的自噬诱导剂。