Ubiquitination/ Proteasome(泛素化/蛋白酶体)

Cat.No. 产品名称 Information

GC35433 Autogramin-1 Autogramin-1 有效抑制由饥饿诱导的自噬 (autophagy)，IC50 为 0.17 μM。Autogramin-1 也抑制 Rapamycin (通过抑制 mTORC1) 诱导的自噬 (autophagy)，IC50 为 0.44 μM。

GC35432 Autocamtide-2-related inhibitory peptide (TFA) A CaMKII inhibitor

GC35419 Atorvastatin

阿托伐他汀

阿托伐他汀（Atorvastatin）是一种口服活性HMG-CoA还原酶抑制剂，可以有效降低血脂

GC35322 Amiodarone

胺碘酮

Amiodarone (NSC 85442,Amiodar,Amiodarone hydrochloride,Nexterone) HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias.

GC35268 AGN 205728 AGN 205728是选择性RARγ拮抗剂，Ki/IC95分别为3 nM/ 0.6 nM，对RARα和RARβ无抑制性。

GC35267 AGN 205327 AGN 205327是RAR激动剂，对RARα/β/γ的EC50分别为3766/734/32 nM，对RXR无抑制性。

GC35266 AGN 196996 AGN 196996是高活性RARα选择性抑制剂，Ki为2 nM，对RARβ和RARγ的亲和性极低（Ki分别为1087 nM和8523 nM）。

GC35265 AGN 195183

IRX-5183; VTP-195183; NRX-195183

AGN 195183是RARα选择性激动剂，Kd为3 nM，相对于AGN 193836有更好的结合选择性，对RARβ/γ无活性。

GC35262 Afzelin

阿福豆苷,Kaempferol-3-O-rhamnoside

A polyphenolic glycoside flavone with diverse biological activities

GC35242 Actein

黄肉楠碱

Actein 是从 Cimicifuga foetida 的根茎中分离的三萜糖苷。Actein 通过促进 ROS/JNK 活化和钝化人膀胱癌中的 AKT 途径来抑制细胞增殖，诱导自噬和凋亡。Actein 在体内几乎没有毒性。

GC35238 Aclacinomycin A hydrochloride

盐酸阿柔比星; Aclarubicin hydrochloride

Aclacinomycin A hydrochloride (Aclarubicin hydrochloride) 是一种荧光分子，是第一个发现对 20S 蛋白酶体 (20S proteasome) 的CTRL (糜凝乳蛋白酶样) 活性具有离散特异性的非肽性抑制剂。

GC35228 Aceglutamide

乙酰谷酰胺; α-N-Acetyl-L-glutamine; N2-Acetylglutamine

An acetylated form of L-glutamine

GC35211 A-317491 sodium salt hydrate A P2X₃ and P2X_2/3 receptor antagonist

GC35132 4-Hydroxylonchocarpin

异补骨脂色烯查耳酮

4-Hydroxylonchocarpin 是一种查尔酮化合物，来自补骨脂 (Psoralea corylifolia) 提取物。4-Hydroxylonchocarpin 增强 p38 MAPK，JNK 和 ERK 的磷酸化。4-Hydroxylonchocarpin 具有多种药理活性，包括抗菌，抗癌，抗逆转录酶，抗结核，抗疟，抗炎和抗氧化活性。

GC35112 3'-Hydroxypterostilbene

3’-羟基紫檀茋

3'-Hydroxypterostilbene (3'-HPT) is one of the active constituents of Sphaerophysa salsula and Pterocarpus marsupium which may be useful in treating different types of haematological malignancies. 3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells (IC50s of 9.0, 40.2, and 70.9 ?M for COLO 205, HCT-116, and HT-29 cells, respectively) by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene inhibits the PI3K/Akt/mTOR/p70S6K, and p38MAPK pathways and activates the ERK1/2, JNK1/2 MAPK pathways.

GC35068 1-Monomyristin

1-肉豆蔻酸单甘油酯

A monoacylglycerol

GC34960 (+)-Talarozole (+)-Talarozole 是视黄酸代谢的有效抑制剂，来自专利 WO 1997049704 A1。

GC45187 Zoledronic Acid (hydrate)

唑来膦酸一水合物; Zoledronate monohydrate; CGP 42446 monohydrate; CGP42446A monohydrate; ZOL 446 monohydrate

A bisphosphonate that inhibits bone resorption

GC45185 Z-LLL-AMC

Z-Leu-Leu-Leu-AMC, Z-Leu-Leu-Leu-7-amido-4-Methylcoumarin, Proteasome Substrate I

A fluorogenic substrate for proteasomal chymotrypsin-like activity

GC45184 Z-LLE-AMC

N-[(苯基甲氧基)羰基]-L-亮氨酰-L-亮氨酰-N-(4-甲基-2-氧代-2H-1-苯并吡喃-7-基)-L-ALPHA-谷氨酰胺

A fluorogenic substrate for proteasomal caspase-like activity

GC45099 U-0126

1,4-二氨基-2,3-二氰基-1,4-双(邻氨基苯巯基)丁二烯

A MEK inhibitor and AMPK activator

GC45064 Tomatidine (hydrochloride)

盐酸番茄碱

A steroidal alkaloid with diverse biological activities

GC44963 Suc-Leu-Tyr-AMC

N-琥珀酰基-亮氨酰-酪氨酸-7-胺基-4-甲基香豆素

Suc-Leu-Tyr-AMC是一种测量20S蛋白酶体凝乳胰蛋白酶样肽酶活性的calpain I和II和papain（半胱氨酸蛋白酶）荧光底物，发出明亮的荧光，已广泛用于calpain I和II和pap蛋白酶的评价（激发/发射光：360/460nm）。

GC44856 Rutin (hydrate)

芦丁三水合物; Rutoside trihydrate; Quercetin 3-O-rutinoside trihydrate

A flavonoid glycoside with diverse biological activities

GC44839 Ridaifen-B An analog of tamoxifen

GC44797 Quinacrine analog 34 An autophagy inhibitor

GC44680 Pregnenolone sulfate (sodium salt)

3β-Hydroxy-5-pregnen-20-one monosulfate sodium

A metabolite of pregnenolone

GC44464 NSC 109555

DDUG, NCI C04808

An inhibitor of Chk2

GC44400 Niclosamide (ethanolamine salt)

氯硝柳胺乙醇胺盐,BAY2353 olamine

氯硝柳胺是一种经美国食品和药物管理局 (FDA) 批准用于治疗肠道蛔虫感染的驱虫药。

GC44346 N-Desethylamiodarone (hydrochloride)

去乙基胺碘酮,N-desethylamiodarone hydrochloride; LB 33020 hydrochloride

A CYP3A4 metabolite of amiodarone

GC44291 NAB 2 An inhibitor of α-synuclein-induced toxicity

GC44290 NAADP (sodium salt)

Nicotinic acid adenine dinucleotide phosphate

A secondary messenger that induces calcium mobilization

GC44059 LG 100268

6-[1-(5,6,7,8-四氢-3,5,5,8,8-五甲基-2-萘基)环丙基]-3-吡啶羧酸,LG268

An RXR agonist

GC43999 Ketanserin (tartrate)

酒石酸酮色林,R41468 tartrate

A potent 5-HT₂ receptor antagonist

GC43922 Isovaleryl-L-carnitine (chloride)

L-异戊酰基肉碱

An acylcarnitine

GC43599 Emetine (hydrochloride)

盐酸吐根碱

An alkaloid with diverse biological activities

GC43359 Cytochalasin E

细胞松弛素E

Inhibitor of actin polymerization

GC43354 Cysmethynil

Icmt Inhibitor

An inhibitor of protein prenylation

GC43321 CPTH6 (hydrobromide) A Gcn5 and pCAF HAT inhibitor

GC43265 Chromomycin A2

色霉素A2

An antibacterial and anticancer aureolic acid

GC43189 CAY10681 A dual modulator of p53-MDM2 interaction and NF-κB signaling

GC43144 Carfilzomib Impurity 13 (hydrochloride) A potential impurity found in commercial carfilzomib preparations

GC43105 C8 Ceramide (d18:1.8:0)

N-辛酰基-D-神经鞘氨醇; N-Octanoyl-D-erythro-sphingosine

A cell-permeable ceramide analog

GC43048 C18 dihydro Ceramide (d18:0/18:0)

二羟基神经酰胺,Cer(d18:0/18:0)

A bioactive sphingolipid

GC42958 Boc-LRR-AMC

Boc-Leu-Arg-Arg-AMC, Boc-Leu-Arg-Arg-7-amido-4-Methylcoumarin

Boc-LRR-AMC是胰蛋白酶体的荧光底物，与20S蛋白酶体类似。

GC42720 Ac-WLA-AMC

Acetyl-Trp-Leu-Ala-7-amino-4-Methylcoumarin, Ac-Trp-Leu-Ala-AMC

A fluorogenic substrate for the 20S proteasome

GC42712 Ac-RLR-AMC (trifluoroacetate salt)

Ac-Arg-Leu-Arg-AMC, Ac-Arg-Leu-Arg-7-amino-4-Methylcoumarin

A fluorogenic substrate for the 26S proteasome

GC42710 Ac-PAL-AMC

Acetyl-Pro-Ala-Leu-7-amino-4-Methylcoumarin, Ac-Pro-Ala-Leu-AMC

A fluorogenic substrate for the 20S proteasome

GC42685 Ac-ANW-AMC

Ac-Ala-Asn-Trp-AMC

Ac-ANW-AMC是20S免疫蛋白酶体的β5i（LMP7/PSMB8）亚基的荧光底物，最大激发波长λ_Ex=345nm, 最大发射波长λ_E_m=445nm。

GC42677 ABO (hydrochloride) A modulator of annexin A7