Ubiquitination/ Proteasome(泛素化/蛋白酶体)

Cat.No. 产品名称 Information

GC34096 (R)-(-)-Gossypol acetic acid (AT-101 (acetic acid))

(R)-(-)-醋酸棉酚; AT-101 (acetic acid); (-)-Gossypol acetic acid; (R)-Gossypol acetic acid

(R)-(-)-Gossypol (AT-101) acetic acid, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM in cell-free assays; does not inhibit BIR3 domain and BID. AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy. Phase 2.

GC34094 Mycro 3 Mycro 3 is a potent and selective inhibitor of c-Myc in whole cell assays. Mycro 3 also shows weak inhibitory activity against AP-1.

GC34072 Talmapimod (SCIO-469)

他匹莫德; SCIO-469

A p38 MAPK inhibitor

GC34057 TBHQ (tert-Butylhydroquinone)

特丁基对苯二酚; tert-Butylhydroquinone

TBHQ(tert-Butylhydroquinone)是一种强效的酚类抗氧化剂，能够减轻氧化应激和炎症反应。

GC34035 Meglutol (Dicrotalic acid)

3-羟基-3-甲基谷氨酸,Dicrotalic acid; 3-Hydroxy-3-methylglutaric acid

An HMG-CoA reductase inhibitor

GC34014 Trimetazidine dihydrochloride

盐酸曲美他嗪

An Analytical Reference Standard

GC34010 Danshensu (Dan shen suan A)

丹参素; Dan shen suan A; Salvianic acid A

丹参素是丹参的一种活性成分，通过激活 Nrf2 信号通路显示出广泛的心血管益处。

GC34009 Nitroprusside disodium dihydrate (Sodium nitroprusside dihydrate)

硝普钠二水合物; Sodium nitroprusside dihydrate; Sodium Nitroferricyanide(III) Dihydrate

Sodium Nitroprusside Dihydrate is a potent vasodilator working through releasing NO spontaneously in blood.

GC33848 Fludrocortisone acetate (9α-Fludrocortisone acetate)

醋酸氟氢可的松; 9α-Fludrocortisone acetate; 9α-Fluorcortisol acetate

A mineralocorticoid agonist

GC33833 Tetrahydrocurcumin (HZIV 81-2)

四氢姜黄素; HZIV 81-2

A metabolite of curcumin with diverse biological activities

GC33779 Cysteamine (β-Mercaptoethylamine)

巯基乙胺

2-Aminoethanethiol (cysteamine, β-Mercaptoethylamine, 2-Mercaptoethylamine, Thioethanolamine, Mercaptamine) is a radiation-protective agent that oxidizes in air to form cystamine.

GC33775 Rimacalib (SMP 114)

SMP 114

Rimacalib (SMP 114) (SMP 114) 是一种 Ca2+/钙调蛋白依赖性蛋白激酶 II (CaMKII) 抑制剂，IC50 为 ~1 μ；M 代表 CaMKIIα；至 ~30 μ；M 代表 CaMKIIγ；。

GC33743 Alicapistat (ABT-957)

ABT-957

Alicapistat (ABT-957) (ABT-957) 是一种口服有效的人类钙蛋白酶 1 和 2 选择性抑制剂，可用于治疗阿尔茨海默病's disease (AD)。

GC33732 Syntide 2 A protein kinase substrate

GC33715 Fluoxetine (LY-110140)

氟西汀; LY-110140 free base

氟西汀Fluoxetine (LY-110140)是一种具有口服活性的选择性5-羟色胺再摄取抑制剂（SSRI），常用于治疗抑郁症、强迫症、恐慌症等多种精神疾病。

GC33683 Autocamtide 2 (Autocamtide II)

Autocamtide II

Autocamtide 2 (Autocamtide II) 是钙/钙调蛋白依赖性蛋白激酶 II (CaMKII) 的高选择性肽底物。

GC33529 Sulfabenzamide (N-Sulfanilylbenzamide)

苯甲酰磺胺; N-Sulfanilylbenzamide

Sulfabenzamide (Sultrin, N-Sulfanilylbenzamide) is an antibacterial/antimicrobial which also exhibit their antitumor effects through multiple mechanisms including inhibition of membrane bound carbonic anhydrases, prevention of microtubule assembly, cell cycle arrest, and inhibition of angiogenesis.

GC33464 Oxyresveratrol (trans-Oxyresveratrol)

氧化白藜芦醇; trans-Oxyresveratrol

A resveratrol analog

GC33446 Oxyphenisatin acetate

双醋酚丁

Oxyphenisatinacetate是oxyphenisatin的前体药物，过去常用作泻药。

GC19485 DC661 A PPT1 inhibitor

GC33377 KSI-3716 KSI-3716是c-Myc的抑制剂。

GC33315 AGN 194078 AGN194078是一个有选择性的RARα激动剂，其Kd和EC50值分别为3和112nM。

GC33311 Proteasome-IN-1 Proteasome-IN-1是一个蛋白酶体抑制剂，来自专利WO2013142376A1。

GC33238 SJFδ SJFδ是一种含10个原子连接桥的PROTAC。SJFδ降解p38α，DC50为46.17nM，但不降解其他p38亚型(p38α,p38β和p38γ)。

GC33229 SJFα SJFα是一种含13个原子连接桥的PROTAC。SJFα降解p38α，DC50为7.16nM，但降解p38δ效果较差(DC50=299nM)，且在浓度高达2.5μM时也不会降解其他p38亚型(β和γ)。

GC33218 CA-5f CA-5f 是一种有效的晚期巨自噬/自噬抑制剂，通过抑制自噬体-溶酶体融合。 CA-5f 增加 LC3B-II（一种监测自噬的标志物）和 SQSTM1 蛋白，并且还增加 ROS 的产生。抗肿瘤活性。

GC33126 Lucanthone

硫蒽酮

Lucanthone is a novel autophagic inhibitor and also an orally available thioxanthone-based DNA intercalator and inhibitor of the DNA repair enzyme apurinic-apyrimidinic endonuclease 1.

GC33085 Glaucocalyxin B

蓝萼乙素

GlaucocalyxinB是从中药香茶菜中分离出来的对映-贝壳杉烷型二萜，具有抗癌和抗炎活性。24h内减少HL-60生长的IC50值约为5.86μM。

GC33008 p38 MAPK-IN-1 p38MAPK-IN-1是p38MAPK新型高效选择性抑制剂,IC50值68nM。

GC33006 CCT020312 An EIF2AK3 activator

GC33004 Cediranib maleate (AZD-2171 maleate)

西地尼布马来酸盐; AZD-2171 maleate

An inhibitor of VEGF receptor tyrosine kinases

GC33003 Daurisoline ((R,R)-Daurisoline)

蝙蝠葛苏林碱; (R,R)-Daurisoline

An alkaloid with diverse biological activities

GC32998 Ginsenoside Rh4

人参皂苷RH4

Ginsenoside Rh4 is an important active ingredient of traditional Chinese medicine ginseng, which has been shown to inhibit Wnt/β-Catenin, JAK2/STAT3, TGF-β/Smad2/3 and other signaling pathways.

GC32962 QX77 An activator of chaperone-mediated autophagy

GC32959 Corynoxine

柯诺辛

An indole alkaloid

GC32901 ROC-325 An autophagy inhibitor

GC32874 NMS-859 NMS-859是一种有效的，共价的VCP(p97)抑制剂，细胞中分别在60μM和1mMATP的条件下，对野生型VCP的IC50值分别为0.37和0.36μM。

GC32826 Corynoxine B

柯诺辛碱 B

柯诺辛B(CorynoxineB)是吲哚生物碱天然化合物，一个beclin-1-dependent自噬诱导剂。

GC32821 Noscapine ((S,R)-Noscapine)

那可汀

Noscapine是一种口服止咳药,主要通过其σ受体激动剂活性调节,且Noscapine具有抗癌活性。

GC32817 AGN 193109

4-[2-[5,6-二氢-5,5-二甲基-8-(4-甲基苯基)-2-萘基]乙炔基]苯甲酸

AGN193109是一种视黄酸类似物，是有效的，特异性的视黄酸受体(RARs)拮抗剂，可抑制RARα，RARβ和RARγ的活性，Kd值分别为2nM，2nM和3nM。

GC32815 Capzimin Capzimin是有效的，特异性适中的，蛋白酶体异肽酶Rpn11抑制剂。

GC32785 ML327 ML327 is an isoxazole compound that blocks MYC expression and tumor formation in neuroblastoma. ML327 also restores E-cadherin expression with In-Cell Western EC50 of 1.0 μM. ML327 induces apoptosis.

GC32768 Quinacrine dihydrochloride (Mepacrine dihydrochloride) Quinacrine是一种荧光探针，使胆碱能受体蛋白发生构象转变，低μM水平对AML细胞具有作用活性，平均IC50为2.30μM。

GC32767 3BDO

3BDO,MTOR激酶激活剂,自噬抑制剂

A butyrolactone derivative and autophagy inhibitor

GC32765 RA190 RA190, a bis-benzylidine piperidon, is a potent, selective and oral effective inhibitor of proteasome ubiquitin receptor RPN13/ADRM1 with anticancer activity. RA190 triggers ER stress response, p53/p21 signaling axis and autophagy in multiple myeloma cells.