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Home >> Signaling Pathways >> Ubiquitination/ Proteasome

Ubiquitination/ Proteasome(泛素化/蛋白酶体)

  1. Cat.No. 产品名称 Information
  2. GC42414 4-hydroxy Tolbutamide

    4-羟基甲苯磺丁脲,Hydroxytolbutamide

     A CYP2C8 and CYP2C9 metabolite of tolbutamide
  3. GC41625 Oroxylin A

    千层纸素A; Baicalein 6-methyl ether; 6-Methoxybaicalein

     A flavonoid with diverse biological activities
  4. GC41308 GPP 78

    CAY10618

     Inhibitor of Nampt
  5. GC41242 Acridine Orange

    吖啶橙,NSC 194350

    Acridine Orange是一种可穿透细胞的核酸选择性荧光染料。
  6. GC41233 (R)-MG132

    N-[(苯基甲氧基)羰基]-L-亮氨酰-N-[(1S)-1-甲酰基-3-甲基丁基]-D-亮氨酰胺,(S,R,S)-(-)-MG-132; Z-Leu-D-Leu-Leu-al

     (R)-MG132是一种蛋白酶体抑制剂，IC50为100 nM。
  7. GC40947 2,3-Dimethoxy-5-methyl-p-benzoquinone

    2,3-二甲氧基-5-甲基-1,4-苯醌,CoQ0

     An intermediate in the synthesis of ubiquinones that has anticancer activity
  8. GC40911 Glycine-β-muricholic Acid

    Gly-MCA, GβMCA

    An intestine-selective FXR antagonist
  9. GC40861 Pinosylvin

    赤松素

     A stilbene with diverse biological activities
  10. GC40793 L-erythro Sphinganine (d18:0)

    L-苏式-二氢鞘胺醇

     A bioactive sphingolipid
  11. GC40792 D-threo Sphinganine (d18:0)

    D-苏式二氢鞘氨醇

     A bioactive sphingolipid
  12. GC40775 Dexamethasone

    地塞米松; Hexadecadrol; Prednisolone F

     地塞米松是糖皮质激素家族的一员，可以保护软骨结构和功能免受关节炎相关变化的影响，包括基质丢失、炎症和软骨活力。
  13. GC40769 Asperphenamate

    Anabellamide, Auranamide, NSC 306231

     A fungal secondary metabolite
  14. GC40694 Calpain Inhibitor II

    Calpain inhibitor II

     A non-selective cysteine protease inhibitor
  15. GC40685 Pentoxifylline

    NSC 637086, Oxpentifylline

     Pentoxifylline is a methylxanthine derivative.
  16. GC40484 Ferulic Acid methyl ester

    阿魏酸甲酯; Methyl ferulate

     A lipophilic antioxidant
  17. GC34924 NSC 185058 An inhibitor of ATG4B
  18. GC34918 MW-150 dihydrochloride dihydrate

    MW01-18-150SRM dihydrochloride dihydrate

     An inhibitor of p38α MAPK
  19. GC34862 WYC-209

    4,5-二(羟甲基)-2-苯基-1H-咪唑

     WYC-209是一种合成类视黄醇，能抑制恶性小鼠黑色素瘤肿瘤再生细胞(TRC)的增殖，IC50值为0.19μM。WYC-209主要细胞靶点是维甲酸受体(RARs)。
  20. GC34849 UBCS039 UBCS039 is the first synthetic SIRT6 activator with EC50 of 38 μM,induces a time-dependent activation of autophagy in several human tumor cell lines.
  21. GC34817 Sulfosuccinimidyl oleate sodium

    SSO

    An irreversible inhibitor of CD36
  22. GC34745 PTI-428

    PTI-428

     Nesolicaftor (PTI-428) is a specific cystic fibrosis transmembrane conductance regulator (CFTR) amplifier that increases CFTR expression.
  23. GC34686 Nidufexor

    LMB763

    An FXR partial agonist
  24. GC34649 LMP7-IN-1 LMP7-IN-1 是一种可口服的、有效的、可逆的和高度选择性的免疫蛋白酶体亚基 LMP7 (β5i) 抑制剂。 LMP7-IN-1 对 LMP7 亚基具有高生化 (IC50=3.6 nM) 和细胞 (IC50=3.4 nM) 效力。 LMP7-IN-1 在多发性骨髓瘤异种移植模型中显示出强大的抗肿瘤功效。 LMP7-IN-1 可显着长期抑制肿瘤 LMP7 活性和泛素化蛋白转换，并诱导多发性骨髓瘤细胞凋亡。
  25. GC34532 CFTR corrector 2 FDL169 is a CFTR corrector that is designed to fix and restore the function of the defective CFTR protein.
  26. GC40227 Indomethacin-d4

    吲哚美辛-D4; Indometacin-d4

     An internal standard for the quantification of indomethacin
  27. GC40226 Curcumin-d6

    (1E,4Z,6E)-5-羟基-1,7-二[4-羟基-3-(甲氧基-D3)苯基]-1,4,6-庚三烯-3-酮,Diferuloylmethane-d6; Natural Yellow 3-d6; Turmeric yellow-d6

     An internal standard for the quantification of curcumin
  28. GC40218 (-)-Epigallocatechin Gallate-d3/d4

    EGCG-d3/d4

     An internal standard for the quantification of (–)-epigallocatechin gallate
  29. GC40080 Bosutinib-d8

    SKI-606 D8

     An internal standard for the quantification of bosutinib
  30. GC40065 Meloxicam-d3

    美洛昔康 d3

     An internal standard for the quantification of meloxicam
  31. GC40044 Zymostenol

    Δ8-Cholesterol

     A precursor of cholesterol
  32. GC40007 Malformin A

    Malformin A1

     A cyclopentapeptide fungal metabolite with diverse biological activities
  33. GC34390 Autocamtide 2, amide Autocamtide2,amide是钙调蛋白激酶(CaMK)家族实验的底物(100μMfinalconcentration)。
  34. GC34330 XRK3F2 XRK3F2 is an inhibitor of the p62-ZZ domain that blunts MM-induced Runx2 suppression in vitro, and induces new bone formation and remodeling in the presence of tumor in vivo.
  35. GC34315 ULK-101 ULK-101 is a potent and selective ULK1 inhibitor with IC50 values of 8.3 nM and 30 nM for ULK1 and ULK2, respectively.
  36. GC34173 LG-100064

    4-[(5,6,7,8-四氢-3,5,5,8,8-五甲基-2-萘基)羰基]苯甲酸

     LG-100064是一种类视黄醇X受体(retinoid-X-receptor(RXR))激动剂，对RXRα，RXRβ和RXRγ的EC50值分别为330nM，200nM和260nM；LG-100064可用于癌症研究。
  37. GC34117 SMER18 SMER18是Rapamycin的一种小分子增强剂,充当mTOR非依赖性的的自噬诱导剂。
  38. GC34096 (R)-(-)-Gossypol acetic acid (AT-101 (acetic acid))

    (R)-(-)-醋酸棉酚; AT-101 (acetic acid); (-)-Gossypol acetic acid; (R)-Gossypol acetic acid

     (R)-(-)-Gossypol (AT-101) acetic acid, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM in cell-free assays; does not inhibit BIR3 domain and BID. AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy. Phase 2.
  39. GC34094 Mycro 3 Mycro 3 is a potent and selective inhibitor of c-Myc in whole cell assays. Mycro 3 also shows weak inhibitory activity against AP-1.
  40. GC34072 Talmapimod (SCIO-469)

    他匹莫德; SCIO-469

     A p38 MAPK inhibitor
  41. GC34057 TBHQ (tert-Butylhydroquinone)

    特丁基对苯二酚; tert-Butylhydroquinone

     TBHQ(tert-Butylhydroquinone)是一种强效的酚类抗氧化剂，能够减轻氧化应激和炎症反应。
  42. GC34035 Meglutol (Dicrotalic acid)

    3-羟基-3-甲基谷氨酸,Dicrotalic acid; 3-Hydroxy-3-methylglutaric acid

     An HMG-CoA reductase inhibitor
  43. GC34014 Trimetazidine dihydrochloride

    盐酸曲美他嗪

     An Analytical Reference Standard
  44. GC34010 Danshensu (Dan shen suan A)

    丹参素; Dan shen suan A; Salvianic acid A

     丹参素是丹参的一种活性成分，通过激活 Nrf2 信号通路显示出广泛的心血管益处。
  45. GC34009 Nitroprusside disodium dihydrate (Sodium nitroprusside dihydrate)

    硝普钠二水合物; Sodium nitroprusside dihydrate; Sodium Nitroferricyanide(III) Dihydrate

     Sodium Nitroprusside Dihydrate is a potent vasodilator working through releasing NO spontaneously in blood.
  46. GC33848 Fludrocortisone acetate (9α-Fludrocortisone acetate)

    醋酸氟氢可的松; 9α-Fludrocortisone acetate; 9α-Fluorcortisol acetate

     A mineralocorticoid agonist
  47. GC33833 Tetrahydrocurcumin (HZIV 81-2)

    四氢姜黄素; HZIV 81-2

     A metabolite of curcumin with diverse biological activities
  48. GC33779 Cysteamine (β-Mercaptoethylamine)

    巯基乙胺

     2-Aminoethanethiol (cysteamine, β-Mercaptoethylamine, 2-Mercaptoethylamine, Thioethanolamine, Mercaptamine) is a radiation-protective agent that oxidizes in air to form cystamine.
  49. GC33775 Rimacalib (SMP 114)

    SMP 114

     Rimacalib (SMP 114) (SMP 114) 是一种 Ca2+/钙调蛋白依赖性蛋白激酶 II (CaMKII) 抑制剂，IC50 为 ~1 μ；M 代表 CaMKIIα；至 ~30 μ；M 代表 CaMKIIγ；。
  50. GC33743 Alicapistat (ABT-957)

    ABT-957

     Alicapistat (ABT-957) (ABT-957) 是一种口服有效的人类钙蛋白酶 1 和 2 选择性抑制剂，可用于治疗阿尔茨海默病's disease (AD)。
  51. GC33732 Syntide 2 A protein kinase substrate

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