Autophagy(自噬)

Autophagy is a catabolic process which degrades and recycles long-lived proteins and cytoplasmic organelles through lysosome. It plays an important role in growth regulation and maintenance of homeostasis.

Products for Autophagy

Cat.No. 产品名称 Information
GC19237 Lys01 trihydrochloride
Lys01 trihydrochloride
An inhibitor of autophagy
GC19236 LYN-1604 A ULK1 activator
GC19232 LY2955303 A potent RARγ antagonist
GC19188 HA15 HA15是一种特异性靶向BiP/GRP78/HSPA5的分子，可结合并抑制其ATPase活性，导致BiP与PERK、IRE1α和ATF6分离，从而引发内质网应激。
GC19169 GLPG1837
ABBV-974
A CFTR potentiator
GC19083 Briciclib
ON 014185
An eIF4E inhibitor
GC19040 AS1842856
5-氨基-7-(环己基氨基)-1-乙基-6-氟-1,4-二氢-4-氧代-3-喹啉羧酸
AS1842856是一种细胞渗透性抑制剂,抑制Foxo1转录活性,IC50=33 nM。
GC19035 AR7 A RARα antagonist
GC19019 Acumapimod
BCT197
An inhibitor of p38α MAPK
GC18304 Bicyclol
双环醇; SY801
A hepatoprotective agent
GC18269 SR 18292 SR 18292是一种过氧化物酶体增殖物激活受体γ（PPARγ）共激活因子-1α（PGC-1α）的抑制剂，可促进PGC-1α乙酰化，抑制糖异生基因的表达，并减少肝细胞中葡萄糖的产生。
GC18212 Cilofexor
GS-9674
An FXR ligand
GC18174 BIA 10-2474
3-(1-(环己基(甲基氨基甲酰基)-1H-咪唑-4-基)吡啶1-氧化物
An inhibitor of FAAH
GC15168 Urolithin A
尿石素A

A metabolite of ellagic acid with diverse biological activities
GC14820 (S)-Naproxen
萘普生; (S)-Naproxen
An NSAID and COX inhibitor
GC14918 10074-G5
N-2-联苯基-7-硝基-2,1,3-苯并恶二唑-4-胺
An inhibitor of c-Myc/Max dimerization
GC17768 Lasalocid
那塞罗; Lasalocid-A; Ionophore X-537A; Antibiotic X-537A
An ionophore antibiotic
GC13063 N-Benzylpalmitamide
N-苄基棕榈酰胺,N-Benzylhexadecanamide
A long-chain fatty acid amide
GC10593 BMS-582949 hydrochloride A p38α MAP kinase inhibitor
GC14749 ALLO-1 A smoothened antagonist
GC11989 Nortriptyline (hydrochloride)
盐酸去甲替林; Desmethylamitriptyline hydrochloride; Desitriptilina hydrochloride
A tricyclic antidepressant
GC10133 JNJ-42165279
N-(4-氯-3-吡啶基)-4-[(2,2-二氟-1,3-苯并二恶茂-5-基)甲基]-1-哌嗪甲酰胺
An irreversible FAAH inhibitor
GC13311 Triclosan
三氯生
A broad-spectrum antibacterial agent
GC10331 Ebselen
依布硒; SPI-1005; PZ-51; CCG-39161
Ebselen一种具有谷胱甘肽过氧化物酶样活性的硒代有机化合物，是一种抗炎和抗氧化剂。Ebselen是肌醇单磷酸酶（IMPase）的抑制剂，IC₅₀为1.5μM。
GC12235 Sitagliptin (phosphate)
磷酸西他列汀; MK-0431 phosphate
A DPP-4 inhibitor
GC14591 Hemin chloride
氯化血红素; Hemin chloride
氯化血红素是血红素加氧酶(HO)-1的底物，可诱导多种细胞表达HO-1，发挥抗氧化和抗炎作用。
GC14413 KJ Pyr 9 An inhibitor of c-Myc and v-Myc interaction with Max
GC15814 Pamapimod (R-1503, Ro4402257)
Ro4402257; R1503
An orally bioavailable inhibitor of p38α MAP kinase
GC10436 VPS34-IN1
Vacuolar Protein Sorting 34 Inhibitor 1, Vps34 Inhibitor 1
A potent and selective inhibitor of Vps34
GC14086 MRT68921 An inhibitor of ULK1/2
GC14679 PIK-III
Vacuolar Protein Sorting 34 Inhibitor 2, Vps34-IN2, Vps34 Inhibitor 2
A selective inhibitor of Vps34
GC11365 Nitroxoline
硝羟喹啉; 8-Hydroxy-5-nitroquinoline; 5-Nitro-8-quinolinol
An 8-hydroxyquinoline with diverse biological activities
GC11567 Acetazolamide
乙酰唑胺
An Analytical Reference Standard
GC17310 SR9011 A REV-ERBα/β agonist
GC12035 SR9009
REV-ERB Agonist II

SR9009 是一种合成的 REV-ERB 激动剂，用于治疗肥胖、躁郁症、焦虑症和抑郁症等代谢性疾病。
GC13915 Tizoxanide
替唑尼特; TIZ
An active metabolite of nitazoxanide
GC14371 LY3023414
LY3023414
LY3023414 (LY3023414) potently and selectively inhibits class I PI3K isoforms, DNA-PK, and mTORC1/2 with IC50s of 6.07 nM, 77.6 nM, 38 nM, 23.8 nM, 4.24 nM and 165 nM for PI3Kα, PI3Kβ, PI3Kδ , PI3Kγ, DNA-PK 和 mTOR, 分别。 LY3023414 在低纳摩尔浓度下有效抑制 mTORC1/2。
GC13554 Deferoxamine mesylate
甲磺酸去铁胺; Desferrioxamine B mesylate; DFOM
Deferoxamine mesylate 是一种通过形成稳定的复合物来螯合铁的药物，该复合物可防止铁进入进一步的化学反应，并用于治疗输血依赖性贫血患者的慢性铁过载。
GC11857 Pexmetinib (ARRY-614)
ARRY-614
A dual inhibitor of Tie2 and p38 MAPK
GC11031 PX-478 2HCl PX-478是一种选择性抑制剂，可以抑制常规和低氧诱导的HIF-1α水平。
GC17975 Naproxen Sodium
萘普生钠
Naproxen sodium 是一种 COX-1 和 COX-2 抑制剂，在细胞试验中 IC50 分别为 8.72 和 5.15 μM。
GC13442 Sanguinarine chloride
氯化血根碱; Sanguinarin chloride; Sanguinarium chloride; Pseudochelerythrine chloride
A natural alkaloid with anti-inflammatory and anti-oxidant properties
GC17901 Tamoxifen
他莫昔芬; ICI 47699; (Z)-Tamoxifen; trans-Tamoxifen
Tamoxifen(他莫西芬)是一种选择性雌激素受体调节剂 (SERM),可阻断乳腺细胞中的雌激素作用,并可激活不同组织细胞中的雌激素活性;Tamoxifen 还可以作为 Hsp90 激活剂,增强 Hsp90 分子伴侣 ATPase 的活性;Tamoxifen 还可以诱导 CreER(T2) 小鼠的基因敲除。
GC13526 Spautin-1
Spautin-1抑制剂
An autophagy inhibitor
GC14476 Entrectinib
恩曲替尼; NMS-E628; RXDX-101
A pan-Trk, ROS1, and ALK inhibitor
GC14644 SBE 13 HCl A potent Plk1 inhibitor
GC15654 SBI-0206965
SBI-0206965，这种嘧啶衍生物是一种高选择性的激酶ULK1抑制剂，IC₅₀值为108nM。
GC13980 LY3009120
DP-4978
LY3009120 是一种泛 RAF 和 RAF 二聚体抑制剂，可抑制所有 RAF 亚型并占据 RAF 二聚体中的两个原聚体。
GC13790 MHY1485 MHY1485 是一种有效的 mTOR 激活剂，可抑制自噬以及自噬体与溶酶体之间的融合。
GC14707 Purvalanol A
NG-60
A selective inhibitor of cyclin-dependent kinases