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Home >> Signaling Pathways >> Ubiquitination/ Proteasome >> Autophagy

Autophagy(自噬)

Autophagy is a catabolic process which degrades and recycles long-lived proteins and cytoplasmic organelles through lysosome. It plays an important role in growth regulation and maintenance of homeostasis.

Products for  Autophagy

  1. Cat.No. 产品名称 Information
  2. GC10436 VPS34-IN1

    Vacuolar Protein Sorting 34 Inhibitor 1, Vps34 Inhibitor 1

     A potent and selective inhibitor of Vps34
  3. GC14086 MRT68921 An inhibitor of ULK1/2
  4. GC14679 PIK-III

    Vacuolar Protein Sorting 34 Inhibitor 2, Vps34-IN2, Vps34 Inhibitor 2

     A selective inhibitor of Vps34
  5. GC11365 Nitroxoline

    硝羟喹啉; 8-Hydroxy-5-nitroquinoline; 5-Nitro-8-quinolinol

     An 8-hydroxyquinoline with diverse biological activities
  6. GC11567 Acetazolamide

    乙酰唑胺

     An Analytical Reference Standard
  7. GC17310 SR9011 A REV-ERBα/β agonist
  8. GC12035 SR9009

    REV-ERB Agonist II

    SR9009 是一种合成的 REV-ERB 激动剂，用于治疗肥胖、躁郁症、焦虑症和抑郁症等代谢性疾病。
  9. GC13915 Tizoxanide

    替唑尼特; TIZ

     An active metabolite of nitazoxanide
  10. GC14371 LY3023414

    LY3023414

     LY3023414 (LY3023414) potently and selectively inhibits class I PI3K isoforms, DNA-PK, and mTORC1/2 with IC50s of 6.07 nM, 77.6 nM, 38 nM, 23.8 nM, 4.24 nM and 165 nM for PI3Kα, PI3Kβ, PI3Kδ , PI3Kγ, DNA-PK 和 mTOR, 分别。 LY3023414 在低纳摩尔浓度下有效抑制 mTORC1/2。
  11. GC13554 Deferoxamine mesylate

    甲磺酸去铁胺; Desferrioxamine B mesylate; DFOM

     Deferoxamine mesylate 是一种通过形成稳定的复合物来螯合铁的药物，该复合物可防止铁进入进一步的化学反应，并用于治疗输血依赖性贫血患者的慢性铁过载。
  12. GC11857 Pexmetinib (ARRY-614)

    ARRY-614

     A dual inhibitor of Tie2 and p38 MAPK
  13. GC11031 PX-478 2HCl PX-478是一种选择性抑制剂，可以抑制常规和低氧诱导的HIF-1α水平。
  14. GC17975 Naproxen Sodium

    萘普生钠

     Naproxen sodium 是一种 COX-1 和 COX-2 抑制剂，在细胞试验中 IC50 分别为 8.72 和 5.15 μM。
  15. GC13442 Sanguinarine chloride

    氯化血根碱; Sanguinarin chloride; Sanguinarium chloride; Pseudochelerythrine chloride

     A natural alkaloid with anti-inflammatory and anti-oxidant properties
  16. GC17901 Tamoxifen

    他莫昔芬; ICI 47699; (Z)-Tamoxifen; trans-Tamoxifen

     Tamoxifen(他莫西芬)是一种选择性雌激素受体调节剂 (SERM),可阻断乳腺细胞中的雌激素作用,并可激活不同组织细胞中的雌激素活性;Tamoxifen 还可以作为 Hsp90 激活剂,增强 Hsp90 分子伴侣 ATPase 的活性;Tamoxifen 还可以诱导 CreER(T2) 小鼠的基因敲除。
  17. GC13526 Spautin-1

    Spautin-1抑制剂

     An autophagy inhibitor
  18. GC14476 Entrectinib

    恩曲替尼; NMS-E628; RXDX-101

     A pan-Trk, ROS1, and ALK inhibitor
  19. GC14644 SBE 13 HCl A potent Plk1 inhibitor
  20. GC15654 SBI-0206965 An ULK1 and ULK2 inhibitor
  21. GC13980 LY3009120

    DP-4978

     LY3009120 是一种泛 RAF 和 RAF 二聚体抑制剂，可抑制所有 RAF 亚型并占据 RAF 二聚体中的两个原聚体。
  22. GC13790 MHY1485 MHY1485 是一种有效的 mTOR 激活剂，可抑制自噬以及自噬体与溶酶体之间的融合。
  23. GC14707 Purvalanol A

    NG-60

     A selective inhibitor of cyclin-dependent kinases
  24. GC17833 Topotecan

    拓扑替康; SKF 104864A; NSC 609669

     Topotecan (SKF 104864A; NSC 609669) 是一种口服有效的拓扑异构酶 I 抑制剂。 Topotecan 在 G0/G1 和 S 期诱导细胞周期停滞并促进细胞凋亡。拓扑替康显示出抗癌活性。
  25. GC12147 PTC209 HBr A BMI-1 inhibitor
  26. GC12804 KN-93 Phosphate A CaMKII inhibitor
  27. GC17242 (-)-epigallocatechin

    (-)-表没食子儿茶素; Epigallocatechin; L-Epigallocatechin

     A green tea polyphenol
  28. GC10603 (-)-epicatechin gallate

    表儿茶素没食子酸酯; Epicatechin gallate; ECG; (-)-Epicatechin 3-O-gallate

     A natural polyphenol with diverse protective actions
  29. GC11635 TA 02 An inducer of cardiomyocyte differentiation
  30. GC13825 TA 01 An inducer of cardiomyocyte differentiation
  31. GC11325 CX-4945 sodium salt

    CX-4945 sodium salt

     A potent, orally bioavailable CK2 inhibitor
  32. GC13023 KC02 Structural analog and inactive form of KC01
  33. GC17538 UNBS 5162 A antagonist of CXCL chemokine expression
  34. GC11471 SAR405 SAR405是一种Vps34抑制剂(IC50=1.2 nM)，SAR405抑制mTOR抑制引起的自噬。
  35. GC12789 KC01 An ABHD16A inhibitor
  36. GC15227 CB-839

    Telaglenastat

     Telaglenastat (CB-839) 是一流的、可逆的和具有口服生物利用度的谷氨酰胺酶 1 (GLS1) 抑制剂。
  37. GC14158 Obeticholic Acid

    奥贝胆酸; INT-747; 6-ECDCA; 6-Ethylchenodeoxycholic acid

     Obeticholic Acid（奥贝胆酸；INT-747；6-ECDCA；6-Ethylchenodeoxycholic acid）是一种有效的，选择性的和口服活性的法尼醇X受体（FXR ）激动剂，EC50为99nM。
  38. GC15004 URMC-099 URMC-099作为一种基于7-氮杂吲哚的MLK3抑制剂，其IC50为14 nM，可特异性影响参与疾病病理生物学的特定aβ物种。
  39. GC12544 Hydroxychloroquine Sulfate

    硫酸羟氯喹; HCQ sulfate

    An aminoquinolone with antimalarial and anti-inflammatory activities
  40. GC17795 Cyclocytidine HCl

    盐酸环胞苷,Cyclocytidine hydrochloride; Cyclo-CMP hydrochloride; Cyclo-C

     A prodrug form of cytarabine
  41. GC12805 Procainamide HCl

    盐酸普鲁卡因胺

     An Analytical Reference Standard
  42. GC10019 SF1670 A selective PTEN inhibitor
  43. GC12646 AL 8697 AL 8697 是一种具有口服活性的特异性 p38α MAPK 抑制剂，IC50 为 6 nM。
  44. GC15642 CHIR 99021 trihydrochloride

    CHIR-99021 trihydrochloride; CT99021 trihydrochloride

     A selective GSK3 inhibitor
  45. GC15077 SA 47 SA 47 是一种选择性强效的脂肪酸酰胺水解酶 (FAAH) 和氨基甲酸酯抑制剂 。
  46. GC18049 GSK2578215A

    5-(2-氟-4-吡啶基)-2-(苯基甲氧基)-N-3-吡啶基苯甲酰胺

     A potent LRRK2 inhibitor
  47. GC12739 A 484954 An eEF-2K inhibitor
  48. GC12693 JZL 195

    4-硝基苯基4-(3-苯氧基苄基)哌嗪-1-甲酸叔丁酯

     A potent inhibitor of both FAAH and MAGL
  49. GC14803 STF 31 A Glut1 inhibitor
  50. GC14272 SMER 28 An enhancer of autophagy
  51. GC10715 GSK 4112

    SR6452

     An agonist of the heme-dependent nuclear receptor REV-ERBα

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