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Home >> Signaling Pathways >> Ubiquitination/ Proteasome >> Autophagy

Autophagy(自噬)

Autophagy is a catabolic process which degrades and recycles long-lived proteins and cytoplasmic organelles through lysosome. It plays an important role in growth regulation and maintenance of homeostasis.

Products for  Autophagy

  1. Cat.No. 产品名称 Information
  2. GC16267 6-Hydroxydopamine hydrobromide

    6-羟基多巴胺氢溴酸盐; 6-Hydroxydopamine hydrobromide; 6-OHDA hydrobromide

     6-Hydroxydopamine hydrobromide (6-OHDA) 是儿茶酚胺、多巴胺和去甲肾上腺素的结构类似物，对儿茶酚胺能神经元发挥毒性作用。
  3. GC11362 K 252a

    SF 2370

     A non-selective PKC inhibitor
  4. GC11200 A23187

    离子载体(钙镁盐混合物),Calcimycin

    A23187自由酸是一种Ca2+离子载体。
  5. GC11598 Diazoxide

    二氮嗪; Sch-6783; SRG-95213

     An activator of SUR1/Kir6.2
  6. GC13931 Bromocriptine mesylate

    甲磺酸溴隐亭; CB-154

     A dopamine receptor agonist
  7. GC12718 Pantoprazole

    泮托拉唑; BY1023; SKF96022

     A proton pump inhibitor
  8. GC12598 AGN 194310

    VTP-194310

     AGN 194310 (VTP-194310) 是一种高亲和力、有效和选择性的视黄酸受体 (RARs) 泛拮抗剂，对 RARα、RARβ、RARγ 的 Kd 值分别为 3 nM、2 nM、5 nM。
  9. GC13664 AM580

    4-[(5,6,7,8-四氢-5,5,8,8-四甲基-2-萘基)甲酰氨基]苯甲酸,CD336; NSC608001; Ro 40-6055

     A selective RARα agonist
  10. GC13717 Losmapimod

    洛批莫德; GSK-AHAB; GW856553X; SB856553

     A dual p38α and p38β MAPK inhibitor
  11. GC15462 ISRIB (trans-isomer)

    ISRIB(TRANS-ISOMER)抑制剂

     An inhibitor of the Integrated Stress Response
  12. GC13104 4E1RCat

    eIF4E/eIF4G Interaction Inhibitor II

     An eIF4F inhibitor
  13. GC10468 4EGI-1

    eIF4E/eIF4G Interaction Inhibitor

     An inhibitor of mRNA translation
  14. GC14298 DMH-1

    BMP Inhibitor II, DorsoMorphin Homolog 1, VU036482

     A potent ALK2 inhibitor
  15. GC16237 Apocynin

    香草乙酮; Acetovanillone

     An acetophenone with antioxidant and anti-inflammatory activities
  16. GC12616 Crizotinib hydrochloride

    克里唑替尼盐酸,PF-02341066 hydrochloride

     Crizotinib hydrochloride (PF-02341066 hydrochloride) 是一种具有口服生物利用度、选择性和 ATP 竞争性的双重 ALK 和 c-Met 抑制剂，IC50 分别为 20 和 8 nM。 Crizotinib hydrochloride (PF-02341066 hydrochloride) 在基于细胞的试验中抑制 NPM-ALK 的酪氨酸磷酸化和 c-Met 的酪氨酸磷酸化，IC50 分别为 24 和 11 nM。它也是一种 ROS 原癌基因 1 (ROS1) 抑制剂。 Crizotinib hydrochloride (PF-02341066 hydrochloride) 具有有效的肿瘤生长抑制作用。
  17. GC10829 Heparin

    肝素

     肝素是一种高度硫酸化的糖胺聚糖，被广泛用作注射用抗凝剂，在任何已知生物分子中具有最高的负电荷密度。
  18. GC17995 Tacrolimus monohydrate

    他克莫司一水合物; FK506 monohydrate; Fujimycin monohydrate; FR900506 monohydrate

     他克莫司一水合物 (FK506 monohydrate) 是一种大环内酯，与 FK506 结合蛋白 (FKBP) 结合形成复合物并抑制钙调神经磷酸酶，从而抑制 T 淋巴细胞信号转导和 IL-2 转录。
  19. GC16993 PFK-015 A selective inhibitor of PFKFB3
  20. GC10441 Cabergoline

    卡麦角林; FCE-21336

     A potent and selective dopamine D2 receptor agonist
  21. GC16105 Iohexol

    碘海醇

     A contrast reagent
  22. GC13869 Fasudil

    法舒地尔; HA-1077; AT877

     Fasudil（法舒地尔；HA-1077；AT877）是一种非特异性RhoA/ROCK抑制剂，对ROCK1的Ki为0.33μM，IC50为0.158μM，对ROCK2和PKA、PKC、PKG的IC50分别为4.58μM、12.30μM、1.650μM。
  23. GC17616 PPQ-102

    CFTR Inhibitor

     A CFTR channel inhibitor
  24. GC10579 Ouabain Octahydrate

    乌本(箭毒)苷,哇巴因,Acocantherine; G-Strophanthin

     Ouabain Octahydrate 是 Na+/K+-ATPase 的抑制剂，用于治疗充血性心力衰竭。
  25. GC16843 Hydroxyurea

    羟基脲; Hydroxycarbamide

     An antineoplastic agent
  26. GC15212 Divalproex Sodium

    双丙戊酸钠,VPA (sodium)

     A prodrug form of valproic acid
  27. GC10976 Noradrenaline bitartrate monohydrate

    酒石酸去甲肾上腺素; Levarterenol bitartrate monohydrate; L-Noradrenaline bitartrate monohydrate

     An adrenoceptor agonist
  28. GC14577 Sulfacetamide Sodium

    磺胺醋酰钠

     A sulfonamide antibiotic
  29. GC14142 Acetylcholine Chloride

    氯化乙酰胆碱; ACh chloride

     A neurotransmitter
  30. GC12017 Isoniazid

    异烟肼; INH; Isonicotinic acid hydrazide; Isonicotinic hydrazide

     An inhibitor of mycolic acid synthesis
  31. GC12226 Cisatracurium Besylate

    顺苯磺酸阿曲库铵; 51W89

     A competitive antagonist of nAChRs and non-depolarizing muscle relaxant
  32. GC15857 Sodium butyrate

    丁酸钠

     A short-chain fatty acid and HDAC inhibitor
  33. GC17082 Pirarubicin

    吡柔比星; THP

     An anthracycline antitumor antibiotic
  34. GC16486 Novobiocin Sodium

    新生霉素钠,Albamycin sodium; Cathomycin sodium

     An inhibitor of DNA gyrase
  35. GC14563 Ketanserin

    酮色林; R41468

     A potent 5-HT2 receptor antagonist
  36. GC17974 Latrepirdine dihydrochloride

    2,3,4,5-四氢-2,8-二甲基-5-[2-(6-甲基-3-吡啶基)乙基]-1H-吡啶并[4,3-B]吲哚二盐酸盐,Dimebolin dihydrochloride

     A neuroprotective agent
  37. GC12376 Maprotiline HCl

    盐酸马普替林

     A tricyclic antidepressant
  38. GC17229 Paroxetine HCl

    盐酸帕罗西汀; BRL29060 hydrochloride; BRL29060A

     A selective serotonin reuptake inhibitor
  39. GC16999 Nitrendipine

    尼群地平; BAY-E-5009

     An L-type calcium channel blocker
  40. GC14216 Chlorpromazine HCl

    盐酸氯丙嗪

     Chlorpromazine HCl是一种口服有效的、可透过血脑屏障的吩噻嗪类抗精神病药，能够有效抑制D2多巴胺受体和5-HT2A，具有很强的镇静作用。
  41. GC15024 Nifedipine

    硝苯地平; BAY-a-1040

     An L-type calcium channel blocker
  42. GC16921 Bromhexine HCl

    盐酸溴己新

     Bromhexine HCl 是一种有效且特异性的 TMPRSS2 蛋白酶抑制剂，IC50 为 0.75 μM。
  43. GC13974 Salbutamol Sulfate

    沙丁胺醇半硫酸盐; Albuterol hemisulfate; AH-3365 hemisulfate

     A β2-AR agonist
  44. GC10750 Dexmedetomidine HCl

    盐酸右美托咪定; (+)-Medetomidine hydrochloride; (S)-Medetomidine hydrochloride

     An α2-adrenoceptor agonist
  45. GC10132 Ciclopirox

    环吡酮胺; HOE296b

     An iron chelator, antifungal, and anticancer agent
  46. GC11885 Sevelamer HCl

    盐酸司维拉姆

     Sevelamer HCl 是一种磷酸盐结合药物，用于治疗慢性肾病患者的高磷血症；由与环氧氯丙烷交联的聚烯丙胺组成。
  47. GC14273 TTNPB (Arotinoid Acid)

    Ro 13-7410; Arotinoid acid; AGN191183

     A potent, selective RAR agonist
  48. GC13031 Trifluoperazine 2HCl

    盐酸三氟拉嗪；甲哌氟丙嗪；三氟吡拉嗪

     An anti-adrenergic and anti-dopaminergic agent
  49. GC10424 Tolbutamide

    甲苯磺丁脲

     A SUR1/Kir6.2 channel inhibitor
  50. GC12736 Thiamet G Thiamet G 是一种有效的 O-GlcNAcase 抑制剂 (Ki =21 nM)，用于提高 O-GlcNAcylation 水平。
  51. GC17151 Tempol

    阻聚剂701,4-Hydroxy-TEMPO

     A nitroxide and spin label with SOD mimetic activity

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