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Home >> Signaling Pathways >> Ubiquitination/ Proteasome >> Autophagy

Autophagy(自噬)

Autophagy is a catabolic process which degrades and recycles long-lived proteins and cytoplasmic organelles through lysosome. It plays an important role in growth regulation and maintenance of homeostasis.

Products for Autophagy

Cat.No. 产品名称 Information
GC10760 XL335
3-(3,4-二氟苯甲酰基)-1,2,3,6-四氢-1,1-二甲基氮杂卓[4,5-B]吲哚-5-甲酸1-甲基乙基酯,FXR-450; XL335; WAY-362450
A potent and selective FXR agonist
GC13071 Ridaforolimus (Deforolimus, MK-8669)
42-(二甲基亚膦酰)雷帕霉素,MK-8669; Deforolimus; AP23573
A rapamycin analog that selectively inhibits mTOR in mTORC1
GC10975 GW4064
3-(2,6-二氯苯基)-4-(3'-羧基-2-氯二苯乙烯-4-基)氧甲基-5-异丙基异恶唑
GW4064作为合成的FXR激动剂，用于治疗胆汁淤积性肝病、代谢综合征和酒精性肝病。
GC17804 GlyH-101
GlyH101, Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor II
A reversible CFTR channel blocker
GC13437 ZLN005 A small molecule activator of PGC-1α expression
GC11056 Itraconazole
伊曲康唑 ; R51211
An antifungal agent and hedgehog pathway inhibitor
GC14507 Azithromycin
阿奇霉素; CP 62993
A macrolide antibiotic
GC16359 Rosuvastatin
瑞舒伐他汀; ZD 4522
An HMG-CoA reductase inhibitor
GC17443 Metformin HCl
盐酸二甲双胍; 1,1-Dimethylbiguanide hydrochloride

A biguanide with diverse biological activities
GC11895 Mevastatin
美伐他汀; Compactin; ML236B
An HMG-CoA reductase inhibitor
GC13667 Temozolomide
替莫唑胺; NSC 362856; CCRG 81045; TMZ
替莫唑胺是一种口服活性烷化剂，可诱导 DNA 中 O6-甲基鸟嘌呤的形成，其在随后的 DNA 复制周期中与胸腺嘧啶错配，从而激活细胞凋亡途径，替莫唑胺可穿过血脑屏障并适用于恶性神经胶质瘤和转移性黑色素瘤。
GC12993 Vancomycin hydrochloride
盐酸万古霉素

A glycopeptide antibiotic
GC12250 Fenofibrate
非诺贝特
A PPARα agonist
GC15575 Tolvaptan
托伐普坦; OPC-41061
A vasopressin V₂ receptor antagonist
GC11048 Irinotecan HCl Trihydrate
盐酸伊立替康三水合物; (+)-Irinotecan hydrochloride trihydrate; CPT-11 hydrochloride trihydrate
A potent inhibitor of DNA topoisomerase I
GC10461 Phenformin HCl
盐酸苯乙福明; Phenethylbiguanide hydrochloride
An antihyperglycemic biguanide
GC10689 PF-4708671 PF-4708671 是一种新型的细胞渗透性 S6K1 抑制剂，特异性抑制 S6K1 亚型，Ki 为 20 nM，IC50 为 160 nM。
GC17331 Salubrinal Salubrinal是有效的选择性真核翻译起始因子2α（eIF2α）去磷酸化抑制剂。
GC12501 KN-93 hydrochloride A selective inhibitor of Ca²⁺/calmodulin-dependent kinase type II
GC10314 Imatinib (STI571)
伊马替尼; STI571; CGP-57148B
伊马替尼 (STI571) (STI571) 是一种口服生物可利用的酪氨酸激酶抑制剂，可选择性抑制 BCR/ABL、v-Abl、PDGFR 和 c-kit 激酶活性。伊马替尼 (STI571) (STI571) 通过在 ATP 结合位点附近结合而起作用，将其锁定在封闭或自我抑制的构象中，从而半竞争性地抑制蛋白质的酶活性。伊马替尼 (STI571) 也是 SARS-CoV 和 MERS-CoV 的抑制剂。
GC11765 Cabazitaxel
卡巴他赛,XRP6258; RPR-116258A; taxoid XRP6258
A semisynthetic taxane
GC11920 Forskolin
毛喉素; Coleonol; Colforsin
Forskolin 是一种有效的腺苷酸环化酶激活剂，对 I 型腺苷酸环化酶的 IC50 为 41 nM。
GC12356 Glibenclamide
格列本脲
格列本脲 (Glyburide) 是一种具有口服活性的 ATP 敏感性 K+ 通道 (KATP) 抑制剂，可用于糖尿病和肥胖症的研究。
GC14304 Palovarotene
4-[(1E)-2-[5,6,7,8-四氢-5,5,8,8-四甲基-3-(1H-吡唑-1-基甲基)-2-萘基]乙烯基]苯甲酸,R 667; Ro 3300074
A RARγ agonist
GC11237 Dexamethasone acetate
醋酸地塞米松
An acetate form of dexamethasone
GC12495 Olanzapine
奥氮平; LY170053
An atypical antipsychotic
GC11432 Amiodarone HCl
盐酸胺碘酮
An antiarrhythmic agent
GC13359 Topotecan HCl
盐酸拓扑替康; SKF 104864A Hydrochloride; NSC 609669 Hydrochloride
A potent inhibitor of DNA topoisomerase I
GC11669 Tamoxifen Citrate
他莫昔芬柠檬酸盐; ICI 46474; (Z)-Tamoxifen Citrate; trans-Tamoxifen Citrate
A selective estrogen receptor modulator
GC16233 Tacrolimus (FK506)
他克莫司; FK506; Fujimycin; FR900506
他克莫司 (FK506) 是一种具有强效免疫抑制作用的大环内酯类抗生素，从筑波链霉菌中分离出来，以前曾用于预防人类同种异体移植和治疗自身免疫性疾病。
GC13350 Raloxifene HCl
盐酸雷洛昔芬; Keoxifene hydrochloride; LY156758; LY139481 hydrochloride
A selective estrogen receptor modulator
GC11637 Mifepristone
米非司酮; RU486; RU 38486
Mifepristone (RU486）是一种口服有效的孕酮（PR）受体和糖皮质激素受体（GR）拮抗剂，用作堕胎药物，体外实验中IC₅₀值分别为0.2nM和2.6nM。
GC11688 Megestrol Acetate
醋酸甲地孕酮
A synthetic progestogen
GC17865 Lomustine
洛莫司汀; CCNU; NSC 79037
A DNA alkylating agent
GC14961 Cytarabine hydrochloride
盐酸阿糖胞苷; Cytosine β-D-arabinofuranoside hydrochloride; Cytosine Arabinoside hydrochloride; Ara-C hydrochloride
A nucleoside analog and prodrug form of ara-CTP
GC11747 Amsacrine hydrochloride
盐酸胺苯吖啶,m-AMSA hydrochloride; acridinyl anisidide hydrochloride
A topoisomerase II poison
GC12326 Amsacrine
安吖啶; m-AMSA; acridinyl anisidide
A topoisomerase II poison
GC10580 AICAR phosphate
5-氨基-1-核糖基咪唑-4-甲酰胺磷酸盐,Acadesine phosphate; AICA Riboside phosphate

An activator of AMPK
GC14292 Apatinib Mesylate
阿帕替尼

A selective VEGFR2 inhibitor
GC11006 Montelukast Sodium
孟鲁司特钠; MK0476
A CysLT₁ receptor antagonist
GC10722 SR-3677
N-[2-[2-(二甲基氨基)乙氧基]-4-(1H-吡唑-4-基)苯基]-2,3-二氢-1,4-苯并二恶烷-2-甲酰胺
A ROCK1 and ROCK2 inhibitor
GC10982 YM201636
6-氨基-N-[3-[4-(4-吗啉基)吡啶并[3',2':4,5]呋喃并[3,2-D]嘧啶-2-基]苯基]-3-吡啶甲酰胺
Inhibitor of PIKfyve
GC12828 Daunorubicin
柔红霉素; Daunomycin; RP 13057; Rubidomycin

Daunorubicin (Daunomycin) 是一种拓扑异构酶 II 抑制剂，具有有效的抗肿瘤活性。
GC10354 Daunorubicin HCl
盐酸柔红霉素; Daunomycin hydrochloride; RP 13057 hydrochloride; Rubidomycin hydrochloride
Antitumor antibiotic used in the treatment of acute myeloid leukemias
GC13858 Torin 2
9-(6-氨基-3-吡啶基)-1-[3-(三氟甲基)苯基]苯并[H]-1,6-萘啶-2(1H)-酮
Selective inhibitor of mTOR
GC13223 Aliskiren Hemifumarate
阿利克仑半富马酸盐; CGP 60536 hemifumarate; CGP60536B hemifumarate; SPP 100 hemifumarate
A nonpeptide renin inhibitor
GC17868 TWS119 A GSK3β inhibitor
GC11424 Valproic acid
丙戊酸; VPA; 2-Propylpentanoic Acid
A class I HDAC inhibitor
GC12389 Efavirenz
依法韦仑; DMP 266; EFV; L-743726
A non-nucleoside reverse transcriptase inhibitor
GC13468 BI-D1870 An inhibitor of RSK1-4