Autophagy(自噬)

Autophagy is a catabolic process which degrades and recycles long-lived proteins and cytoplasmic organelles through lysosome. It plays an important role in growth regulation and maintenance of homeostasis.

Products for Autophagy

Cat.No. 产品名称 Information
GC16587 Nimodipine
尼莫地平; BAY-e 9736
An L-type calcium channel inhibitor
GC10037 Bexarotene
贝沙罗汀; LGD1069
An RXR agonist
GC11762 Meloxicam (Mobic)
美洛昔康
A selective COX-2 inhibitor
GC12363 LY2109761 A dual inhibitor of TGF-β type 1/type II receptor kinases
GC17057 Lithocholic Acid
石胆酸; 3α-Hydroxy-5β-cholanic acid
A toxic secondary bile acid
GC10447 Isradipine (Dynacirc)
伊拉地平,PN 200-110
An L-type calcium channel blocker
GC17556 Indomethacin
吲哚美辛; Indometacin
Indomethacin(吲哚美辛)是一种有效的口服活性 COX1/2 抑制剂,COX-1 和 COX-2 的IC50 值分别为 18 nM 和 26 nM。
GC16805 Gemcitabine
吉西他滨; LY 188011

An anticancer nucleoside analog
GC15605 Ezetimibe
依泽替米贝; SCH 58235
A cholesterol transport inhibitor
GC13029 AZD2014
3-[2,4-双((3S)-3-甲基吗啉-4-基)吡啶并[5,6-E]嘧啶-7-基]-N-甲基苯甲酰胺,AZD 2014; AZD-2014
A potent dual mTORC1/2 inhibitor
GC16526 Atropine
阿托品; Tropine tropate; DL-Hyoscyamine
A non-selective muscarinic acetylcholine receptor antagonist
GC10710 3-Methyladenine
3-甲基腺嘌呤; 3-MA
3-甲基腺嘌呤是一种经典的自噬抑制剂。
GC12730 Pazopanib Hydrochloride
盐酸帕唑帕尼; GW786034 (Hydrochloride)
A multi-kinase inhibitor
GC15455 VX-809
鲁玛卡托; VX-809; VRT 826809
A F508del-CFTR corrector
GC13037 CX-4945 (Silmitasertib)
CX 4945;CX4945
A potent, orally bioavailable CK2 inhibitor
GC14482 Verteporfin
维替泊芬; CL 318952
维替泊芬是一种有效的 PD-L1 表达抑制剂，用于治疗年龄相关性黄斑变性、鲜红斑痣和癌症。
GC10970 WP1130
WP 1130; WP-1130
A deubiquitinase inhibitor
GC15904 PP242
PP242; PP-242
Potent inhibitor of mTOR kinase in both mTORC1 and mTORC2
GC12573 Temsirolimus
西罗莫司脂化物,Torisel;CCI-779;CCI 779;CCI779
A specific inhibitor of mTOR activity
GC15818 RAF265
CHIR-265;RAF 265;RAF-265;CHIR265
A B-Raf and VEGFR2 inhibitor
GC10131 Torin 1
1-[4-[4-(1-氧代丙基)-1-哌嗪基]-3-(三氟甲基)苯基]-9-(3-喹啉基)苯并[H]-1,6-萘啶-2(1H)-酮,Torin1;Torin-1
Torin 1是一种有效的ATP竞争性哺乳动物雷帕霉素靶蛋白（mTOR）抑制剂，IC₅₀值为3nM。
GC15680 Perifosine
哌立福新; KRX-0401; NSC 639966; D21266

Perifosine 是 Akt 的抑制剂。
GC10261 PH-797804
PH797804;PH 797804
A selective p38 MAPK inhibitor
GC14906 Crenolanib (CP-868596)
[1-[2-[5-(3-甲基氧杂环丁烷-3-基甲氧基)苯并咪唑-1-基]喹啉-8-基]哌啶-4-基]胺,CP-868596;CP 868596;CP868596
An inhibitor of PDGFRα/β and FLT3
GC16436 Tenovin-6 A small molecule activator of p53
GC12021 GDC-0349
N-ETHYL-N'-[4-[5,6,7,8-四氢-4-[(3S)-3-甲基-4-吗啉基]-7-(3-氧杂环丁基)吡啶并[3,4-D]嘧啶-2-基]苯基]脲
A potent inhibitor of mTOR
GC14920 VX-661
VX-661
An investigational compound that promotes the maturation of delta F508 CFTR
GC10944 Butein
紫铆因; 2’,3,4,4’-tetrahydroxy Chalcone
A plant polyphenol
GC11752 AZD5363
4-氨基-N-[(1S)-1-(4-氯苯基)-3-羟基丙基]-1-(7H-吡咯并[2,3-D]嘧啶-4-基)-4-哌啶甲酰胺,AZD5363
A pan-Akt inhibitor
GC10359 GANT61
2,2'-[[二氢-2-(4-吡啶基)-1,3(2H,4H)-嘧啶二基]二(亚甲基)]二[N,N-二甲基苯胺],NSC 136476
GANT61 能够有效阻断 GLI1 和 GLI2 诱导的转录，IC50 为 5 μM。
GC10395 Dynasore Dynasore 作为 GTPase 抑制剂，可以快速、可逆地抑制发动蛋白活性，从而阻止内吞作用。
GC12843 MEK162 (ARRY-162, ARRY-438162)
贝美替尼,MEK162; ARRY-162; ARRY-438162
A MEK1/2 inhibitor
GC10596 T0901317
N-(2,2,2-三氟乙基)-N-[4-[2,2,2-三氟-1-羟基-1-(三氟甲基)乙基]苯基]苯磺酰胺
Selective agonist for LXRα and LXRβ
GC17295 10058-F4
5-(4-乙基苯亚甲基)
10058-F4是一种c-Myc抑制剂，抑制c-Myc-Max二聚化，阻止c-Myc靶基因表达的转录激活。
GC11015 PD168393 An irreversible EGFR kinase inhibitor
GC16380 AZD8055
CCG-168
AZD8055是一种新型的ATP竞争性mTOR抑制剂，IC50 为0.8 nmol/L，Ki为1.3 nmol/L。
GC17615 Quizartinib (AC220)
奎扎替尼; AC220
An inhibitor of FLT3
GC14289 Fasudil (HA-1077) HCl
盐酸法舒地尔; HA-1077 Hydrochloride; AT-877 Hydrochloride
Fasudil（法舒地尔；HA-1077；AT877）是一种非特异性RhoA/ROCK抑制剂，对ROCK1的K_i为0.33μM，IC₅₀为0.158μM，对ROCK2和PKA、PKC、PKG的IC₅₀分别为4.58μM、12.30μM、1.650μM。
GC11497 BIRB 796 (Doramapimod)
达马莫德; BIRB 796
A potent inhibitor of p38 MAPK
GC16835 LY2228820
5-[2-(叔丁基)-4-(4-氟苯基)-1H-咪唑-5-基]-3-(2,2-二甲基丙基)-3H-咪唑并[4,5-B]吡啶-2-胺甲磺酸盐,LY2228820 dimesylate
A potent inhibitor of p38α MAP kinase
GC16851 AZD6482
2-[[(1R)-1-[7-甲基-2-(4-吗啉)-4-氧代-4H-吡啶并[1,2-A]嘧啶-9-基]乙基]氨基]苯甲酸,KIN-193
A PI3Kβ inhibitor
GC14574 Tigecycline
替加环素; GAR-936
A glycylcycline antibiotic
GC15459 Tazarotene
他扎罗汀; AGN 190168
A retinoid prodrug
GC14396 Ponatinib (AP24534)
普纳替尼; AP24534
An inhibitor of native and mutant Bcr-Abl
GC12474 AS-605240
5-(6-喹喔啉亚甲基)-2,4-噻唑啉二酮
A potent inhibitor of PI3-kinase γ
GC16868 Sulfasalazine
柳氮磺吡啶; NSC 667219
A prodrug form of 5-aminosalicylic acid
GC13882 Ranolazine 2HCl
盐酸雷诺嗪; CVT 303 dihydrochloride; RS 43285
A piperazine derivative with cardioprotective activity
GC18072 Prazosin HCl
哌唑嗪盐酸盐
An α₁-adrenergic receptor antagonist
GC15197 Saracatinib (AZD0530)
塞卡替尼; AZD0530
A dual inhibitor of c-Src and Abl
GC11473 Irinotecan
伊立替康; (+)-Irinotecan; CPT-11
Irinotecan是一种拓扑异构酶抑制剂，主要用于治疗结直肠癌。Irinotecan可通过与拓扑异构酶 I-DNA 复合物结合，阻止 DNA 链的再连接，并导致 DNA 双链断裂和细胞死亡。