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Home >> Signaling Pathways >> Ubiquitination/ Proteasome >> Autophagy

Autophagy(自噬)

Autophagy is a catabolic process which degrades and recycles long-lived proteins and cytoplasmic organelles through lysosome. It plays an important role in growth regulation and maintenance of homeostasis.

Products for  Autophagy

  1. Cat.No. 产品名称 Information
  2. GC14237 Nilotinib monohydrochloride monohydrate

    尼洛替尼盐酸盐一水合物; AMN107 monohydrochloride monohydrate

     A Bcr-Abl inhibitor
  3. GC17136 MRT67307

    N-[3-[[5-环丙基-2-[[3-(4-吗啉基甲基)苯基]氨基]-4-嘧啶基]氨基]丙基]环丁烷甲酰胺,MRT 67307;MRT-67307

     A kinase inhibitor
  4. GC15854 Mefloquine hydrochloride

    盐酸甲氟喹,Mefloquin hydrochloride

     An antimalarial compound
  5. GC17874 Matrine

    苦参碱; Matridin-15-one; Vegard; α-Matrine

     苦参碱（Matrine）是一种存在于槐属植物中的生物碱，可作为 kappa 阿片受体和µ-受体激动剂。
  6. GC15094 LY2183240

    5-([1,1'-联苯]-4-甲基)-N,N-二甲基-1H-四氮唑-1-甲酰胺,LY 2183240; LY-2183240

     A potent, competitive inhibitor of anandamide uptake
  7. GC10629 KN-93

    N-[2-[N-(4-氯肉桂)-N-甲基氨基]苯基]-N-(2-羟乙基)-4-甲氧苯磺酰胺磷酸酯盐,KN 93;KN93

     Selective inhibitor of Ca2+/calmodulin-dependent kinase type II
  8. GC16981 KN-92 phosphate

    KN-92磷酸盐,KN 92 phosphate;KN92 phosphate

     KN-92 phosphate 是 KN-93 的无活性衍生物，没有 CaM 激酶抑制活性。 KN-92 磷酸盐旨在用作旨在阐明 KN-93 拮抗剂活性的研究中的对照化合物。 KN-93 是一种细胞渗透性、可逆性和竞争性 CaMKII 抑制剂。
  9. GC15988 KN-92 hydrochloride

    KN-92盐酸盐,KN 92 hydrochloride;KN92 hydrochloride

     An inactive control compound for a CaMKII inhibitor
  10. GC14132 KN-92

    KN 92;KN92

     An inactive control compound for a CaMKII inhibitor
  11. GC15684 KB-R7943 mesylate

    KB-R7943甲磺酰酸盐,KB-R7943; KB-R 7943

     An inhibitor of the reverse Na+/Ca2+ exchanger
  12. GC15730 Kaempferide

    山奈素; Kaempferol 4'-O-methyl ether

     A flavonoid with diverse biological activities
  13. GC13316 Ivacaftor hydrate

    VX-770 hydrate;VX 770 hydrate;VX770 hydrate;Kalydeco hydrate

     A CFTR potentiator
  14. GC12489 Ivacaftor benzenesulfonate

    VX-770 benzenesulfonate;VX 770 benzenesulfonate;VX770 benzenesulfonate;Kalydeco benzenesulfonate

     A CFTR potentiator
  15. GC13795 Isobavachalcone

    补骨脂乙素; Corylifolinin; Isobacachalcone

     A chalcone and flavonoid with diverse biological activities
  16. GC10939 Hoechst 33342 trihydrochloride

    2'-(4-乙氧基苯基)-5-(4-甲基-1-哌嗪基)-2,5'-联-1H-苯并咪唑三盐酸盐,bisBenzimide H 33342;HOE 33342;Hoechst-33342;Hoechst33342

    Hoechst 33342 trihydrochloride是一种DNA荧光染料，最大激发/发射光分别为350/460nm。
  17. GC17534 GSK343

    GSK-343;GSK 343

     A selective, cell-permeable EZH2 inhibitor
  18. GC17450 GSK2606414

    GSK 2606414;GSK-2606414

     GSK2606414是一种具有口服活性的选择性蛋白激酶R样内质网激酶（PERK）抑制剂，IC50值为0.4nM。
  19. GC16154 GDC-0941 dimethanesulfonate

    GDC-0941 (2 MeSO3H salt);GDC0941 dimethanesulfonate;GDC-0941;GDC0941;GDC 0941

     A pan inhibitor of class I PI3K isoforms
  20. GC12139 Gambogic Acid

    藤黄酸; Beta-Guttiferrin

     Gambogic Acid 是一种细胞渗透性 caspase 激活剂和细胞凋亡诱导剂，常用于乳腺癌、肺癌和肝癌等的研究。
  21. GC13535 Fluvastatin

    氟伐他汀; XU 62-320 free acid

     An HMG-CoA reductase inhibitor
  22. GC16063 Flavopiridol

    夫拉平度; HMR-1275; Alvocidib; L86-8275

     An inhibitor of cyclin-dependent kinases
  23. GC17143 Fenretinide

    芬维A胺; 4-HPR

     A synthetic retinoic acid derivative
  24. GC13022 Esomeprazole Magnesium trihydrate

    埃索美拉唑镁三水合物; (S)-Omeprazole magnesium trihydrate; (-)-Omeprazole magnesium trihydrate

     An H+/K+-ATPase inhibitor
  25. GC10627 Erlotinib

    埃罗替尼; CP-358774; NSC 718781; OSI-774

     Erlotinib是一种有效且口服生物可利用的表皮生长因子受体（EGFR）酪氨酸激酶抑制剂，IC50值为2 nM。
  26. GC16044 Emodin

    大黄素; Frangula emodin

     Natural CK2 inhibitor and ER agonist
  27. GC10466 EMD-1214063

    特泊替尼

     EMD-1214063（Tepotinib，MSC2156119J）是一种新型强效、高选择性、可逆、ATP 竞争性小分子 c-Met 抑制剂。
  28. GC16073 Dronedarone

    决奈达隆; SR 33589

     An antiarrhythmic agent
  29. GC13202 D4476

    4-[4-(2,3-二氢-1,4-苯并二氧杂环己-6-基)-5-(2-吡啶基)-1H-咪唑-2-基]苯甲酰胺,Casein Kinase I Inhibitor;D 4476;D-4476

     Inhibitor of CK1 and ALK5
  30. GC16468 CYT387 sulfate salt

    N-(氰基甲基)-4-[2-[[4-(4-吗啉基)苯基]氨基]-4-嘧啶基]苯甲酰胺硫酸盐(1:2),CYT-387 sulfate;CYT 387 sulfate

     A potent inhibitor of JAK1 and JAK2
  31. GC14787 Curcumin

    姜黄素; Diferuloylmethane; Natural Yellow 3; Turmeric yellow

     A yellow pigment with diverse biological activities
  32. GC13261 Colchicine

    秋水仙碱

     Colchicine（秋水仙碱）是一种可口服的生物碱，通过抑制β-微管蛋白聚合成微管来破坏细胞骨架功能，Colchicine抑制微管的IC50为3 nM。
  33. GC13065 Chelerythrine Chloride

    盐酸白屈菜红碱

     Potent inhibitor of PKC and Bcl-xL
  34. GC13365 CGI-1746

    N-[3-[4,5-二氢-4-甲基-6-[[4-(4-吗啉基羰基)苯基]氨基]-5-氧代-2-吡嗪基]-2-甲基苯基]-4-(叔丁基)苯甲酰胺,CGI1746;CGI 1746

     A potent, selective BTK inhibitor
  35. GC14065 Capsaicin

    辣椒素; (E)-Capsaicin

     辣椒素是一种高度选择性的瞬时受体电位阳离子通道激动剂，亚家族 V，成员 1 (TRPV1)，一种配体门控的非选择性阳离子通道，优先在小直径感觉神经元上表达 < /sup>。
  36. GC12541 Bilobalide

    白果内酯; (-)-Bilobalide

     A neuroprotective natural product
  37. GC13271 BEZ235 Tosylate

    BEZ235对甲苯磺酸盐,NVP-BEZ 235 Tosylate; BEZ-235 Tosylate

     BEZ235 Tosylate (BEZ235 Tosylate) 是一种双重 PI3K 和 mTOR 激酶抑制剂，对 PI3Kα, β, γ, δ 的 IC50 值分别为 4, 75, 7, 5 nM。 BEZ235 Tosylate (BEZ235 Tosylate) 抑制 mTORC1 和 mTORC2。
  38. GC10480 Betulinic acid

    白桦脂酸; Lupatic acid; Betulic acid

     白桦脂酸（Betulinic acid）是一种天然的五环三萜类化合物，是真核细胞拓扑异构酶I的抑制剂，IC50值为5μM。
  39. GC11572 Bardoxolone methyl

    甲基巴多索隆; RTA 402; NSC 713200; CDDO Methyl ester

     A synthetic triterpenoid with potent anticancer and antidiabetic activity
  40. GC11081 Avermectin B1

    阿维菌素 B1; Abamectin; Avermectin B1a-Avermectin B1b mixt.

     An insecticide and anthelmintic
  41. GC11106 AT-101

    (-)-棉子素,(R)-(-)-Gossypol;R-(-)-gossypol acetic acid;AT 101;AT101

     AT-101 (AT-101) 是天然产物棉酚的左旋异构体。 AT-101 与 Bcl-2、Mcl-1 和 Bcl-xL 蛋白结合，Kis 分别为 260±30 nM、170±10 nM 和 480±40 nM。
  42. GC15451 Aliskiren

    阿利克仑; CGP 60536; CGP60536B; SPP 100

    Aliskiren 是一种具有口服活性的高效选择性肾素抑制剂，IC50 为 1.5 nM。
  43. GC10707 Afatinib dimaleate

    双马来酸盐阿法替尼; BIBW 2992MA2

     An inhibitor of EGFR and ErbB2
  44. GC15014 A-867744

    4-[5-(4-氯苯基)-2-甲基-3-丙酰基吡咯-1-基]苯磺酰胺,A 867744;A867744

     A positive allosteric modulator of α7 nAChRs
  45. GC17710 A-317491

    A 317491;A317491

     A P2X3 and P2X2/3 receptor antagonist
  46. GC12791 3,3'-Diindolylmethane

    3,3'-二吲哚甲烷,diindolylmethane, 3,3'-Methylenediindole,DIM,Arundine,HB236

     A phytochemical with antiradiation and chemopreventative effects
  47. GC12511 Paclitaxel (Taxol)

    紫杉醇

     紫杉醇是从短叶红豆杉的树皮和针叶中提取出来的三环二萜化合物。
  48. GC11610 Pemetrexed

    培美曲塞二钠盐; LY231514 disodium

     An antifolate with anticancer activity
  49. GC16966 VER 155008

    adenosine-derived inhibitor, VER155008, VER-155008

     An Hsp70 inhibitor
  50. GC14308 FK866 (APO866)

    达珀利奈; FK866; APO866

    Inhibitor of nicotinamide phosphoribosyltransferase
  51. GC10330 Lonafarnib

    洛那法尼,Sch 66336, Sch66336, Sch-66336

     A farnesyltransferase inhibitor with antitumor activity

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