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Home >> Signaling Pathways >> Ubiquitination/ Proteasome >> Autophagy

Autophagy(自噬)

Autophagy is a catabolic process which degrades and recycles long-lived proteins and cytoplasmic organelles through lysosome. It plays an important role in growth regulation and maintenance of homeostasis.

Products for  Autophagy

  1. Cat.No. 产品名称 Information
  2. GC48118 Sunitinib-d10

    舒尼替尼-D10,SU 11248-d10

     An internal standard for the quantification of sunitinib
  3. GC48052 Rilmenidine-d4

    Oxaminozoline-d4

     An internal standard for the quantification of rilmenidine
  4. GC48027 Rapamycin-d3

    三氘代雷帕霉素,Sirolimus-d3; AY-22989-d3

     An internal standard for the quantification of rapamycin
  5. GC47735 N-acetyl Desethylchloroquine-d4

    N-acetyl-(mono) Desethylchloroquine

     An internal standard for the quantification of N-acetyl desethylchloroquine
  6. GC47470 Isovaleryl-L-carnitine-d3 (chloride)

    CAR 5:0-d3, C5:0 Carnitine-d3, L-Carnitine isovaleryl ester-d3, L-Isovalerylcarnitine-d3

     A neuropeptide with diverse biological activities
  7. GC47445 Hydroxychloroquine-d4 (sulfate)

    HCQ-d4 sulfate

     An internal standard for the quantification of hydroxychloroquine
  8. GC47436 HT-2 Toxin-13C22

    HT-2毒素-13C22溶液

     An internal standard for the quantification of HT-2 toxin
  9. GC47408 Glycochenodeoxycholic Acid-d4

    甘氨鹅脱氧胆酸-D4,Chenodeoxycholylglycine-d4

     An internal standard for the quantification of glycochenodeoxycholic acid
  10. GC47407 Glycochenodeoxycholic Acid (sodium salt hydrate)

    GCDCA, NSC 681056

     A neuropeptide with diverse biological activities
  11. GC47303 Erlotinib-d6 (hydrochloride)

    埃罗替尼-D6盐酸盐,CP-358774-d6 hydrochloride; NSC 718781-d6 hydrochloride; OSI-774-d6 hydrochloride

     An internal standard for the quantification of erlotinib
  12. GC47284 Elaidic Acid-d17

    C18:1(9E)-d17, 9(E)-Oleic Acid-d17, trans-Oleic Acid-d17

     A neuropeptide with diverse biological activities
  13. GC47195 Desethylchloroquine-d4

    N-Desethylchloroquine-d4

     An internal standard for the quantification of desethylchloroquine
  14. GC47194 Desethylchloroquine

    羟基氯喹EP杂质D-d5二盐酸

     An active metabolite of chloroquine
  15. GC47193 Desethyl Hydroxychloroquine-d4

    Desethylhydroxychloroquine-d4

     An internal standard for the quantification of desethyl hydroxychloroquine
  16. GC47065 CAY10773 A derivative of sorafenib
  17. GC47016 Cabergoline-d6

    FCE-21336-d6

     A neuropeptide with diverse biological activities
  18. GC46989 C18 dihydro Ceramide-d3 (d18:0/18:0-d3)

    N-octadecanoyl-D-erythro-Dihydrosphingosine-d3

     An internal standard for the quantification of C18 dihydro ceramide
  19. GC46923 Bexarotene-d4

    LGD1069 D4

     A neuropeptide with diverse biological activities
  20. GC46897 AUTEN-99

    Autophagy enhancer-99 hydrobromide

     An inhibitor of MRMR14/Jumpy
  21. GC61263 Salvigenin

    三裂鼠尾草素

     A polyphenol flavonoid with diverse biological activities
  22. GC61256 Rupatadine D4 fumarate

    UR-12592 D4 fumarate

     RupatadineD4fumarate(UR-12592D4fumarate)是Rupatadinefumarate的氘代标记物。RupatadineFumarate(UR-12592Fumarate)富马酸盐是PAF/H1受体双抑制剂，Ki值分别为0.55μM和0.1μM。
  23. GC61251 Rosuvastatin D3

    ZD 4522 D3

     RosuvastatinD3(ZD4522D3)是Rosuvastatin的一种氘代化合物。Rosuvastatin(ZD4522)是一种竞争性HMG-CoA还原酶抑制剂，IC50为11nM。Rosuvastatin有效阻断人类醚-a-go-go相关基因(hERG)电流，IC50为195nM，延迟心脏复极化，从而延长动作电位持续时间(APDs)和校正QT间期(QTc)间隔。
  24. GC61229 Quinacrine dihydrochloride

    阿的平; Mepacrine dihydrochloride; SN-390 dihydrochloride

     Quinacrine 2HCl(Quinacrine dihydrochloride) is a lipophilic cationic drug with multiple actions that is commonly used as an anti-protozoal agent. Quinacrine is an effective phospholipase A2 inhibitor.
  25. GC61227 Quercetin D5

    槲皮素 d5

     QuercetinD5是Quercetin的一种氘代化合物。Quercetin是一种天然黄酮类化合物，可激活或抑制许多蛋白质的活性。Quercetin可激活SIRT1，也可抑制PI3K，抑制PI3Kγ，PI3Kδ，PI3Kβ的IC50分别为2.4μM,3.0μM,5.4μM。
  26. GC61183 Physalin B

    酸浆苦味B

     PhysalinB是Capegooseberry中主要的甾体活性成分之一，通过调节p53依赖的凋亡途径，诱导乳腺癌细胞周期阻滞和诱导凋亡(apoptosis)。PhysalinB抑制人结肠癌细胞泛素-蛋白酶体通路并诱导不完全自噬反应。
  27. GC61155 Omeprazole sodium

    奥美拉唑钠,H 16868 sodium

     An irreversible inhibitor of the gastric proton pump
  28. GC61045 Metformin D6 hydrochloride

    二甲双胍盐酸,1,1-Dimethylbiguanide-d6 hydrochloride

     An internal standard for the quantification of metformin
  29. GC61003 Loperamide D6 hydrochloride

    4-[4-(4-氯苯基)-4-羟基哌啶-1-基]-2,2-二苯基-N,N-二(三氘甲基)丁酰胺盐酸盐,R-18553-d6 hydrochloride

     LoperamideD6hydrochloride(R-18553D6hydrochloride)是Loperamidehydrochloride的氘代化合物。Loperamidehydrochloride是一种阿片受体(opioidreceptor)的激动剂，可用于腹泻的研究。
  30. GC60935 Indomethacin sodium hydrate

    吲哚美辛钠盐三水合物; Indometacin sodium hydrate

     A non-selective COX inhibitor
  31. GC60930 Imatinib D4

    [2H4]-伊马替尼,STI571 D4; CGP-57148B D4

     ImatinibD4(STI571D4)是Imatinib(STI571)的氘代物。Imatinib是一种口服生物可用的酪氨酸激酶抑制剂，可选择性抑制BCR/ABL，v-Abl，PDGFR，c-kit激酶活性。
  32. GC60891 GW406108X

    GW108X

     GW406108X (GW108X) is an inhibitor of Kif15 (Kinesin-12) with an IC50 of 0.82 μM in the ATPase assay. GW406108X inhibits recombinant ULK1 kinase activity with a pIC50 of 6.37 and blocks autophagy in cells, without affecting the upstream signalling kinases mTORC1 and AMPK.
  33. GC60882 Glyphosate

    草甘膦

     An herbicide
  34. GC60868 Gefitinib D8

    吉非替尼杂质-D8,ZD1839-d8

     GefitinibD8(ZD1839D8)是Gefitinib的氘代物。Gefitinib是一种有效的(EGFR)抑制剂，在NR6wtEGFR细胞中IC50值为2-37nM。
  35. GC60826 Etoposide phosphate

    磷酸依托泊苷; BMY-40481

     Etoposidephosphate(BMY-40481)是一种有效的抗癌(anti-cancer)化疗试剂和一种选择性拓扑异构酶II(topoisomeraseII)抑制剂，可以防止DNA链的重新连接。Etoposidephosphate是依托泊苷的磷酸酯前药，被认为与Etoposide活性相当。Etoposidephosphate诱导细胞周期阻滞、凋亡(apoptosis)和自噬(autophagy)。
  36. GC60700 Chloroquine D5

    氯喹 d5

     An internal standard for the quantification of chloroquine
  37. GC60668 Calcimycin hemimagnesium

    CALIMYCIN半镁盐,A-23187 hemimagnesium; Antibiotic A-23187 hemimagnesium

     Calcimycin(A-23187)hemimagnesium是一种抗生素和独特的二价阳离子离子载体(divalentcationionophore)，如钙离子和镁离子。Calcimycinhemimagnesium通过增加细胞内钙浓度诱导Ca2+依赖性细胞死亡。Calcimycinhemimagnesium抑制革兰氏阳性细菌和一些真菌的生长，还抑制ATP酶的活性并解耦哺乳动物细胞的氧化磷酸化(OXPHOS)，诱导细胞凋亡(apoptosis)。
  38. GC60567 Afatinib impurity 11 Afatinib impurity 11 is an impurity of afatinib, an EGFR family inhibitor.
  39. GC60395 (3S,5R)-Fluvastatin D6

    (3S,5R)-XU 62-320 free acid D6

     (3S,5R)-FluvastatinD6是(3S,5R)-Fluvastatinsodium的氘代物。Fluvastatin是第一个完全合成的，竞争性的HMG-CoAreductase还原酶抑制剂，IC50为8nM。Fluvastatin通过依赖Nrf2的抗氧化通路保护血管平滑肌细胞免受氧化应激。
  40. GC60325 Rilmenidine

    利美尼啶

     An antihypertensive agent
  41. GC60245 Metformin

    二甲双胍; 1,1-Dimethylbiguanide

     二甲双胍（1,1-二甲基双胍）主要介导 AMPK 的激活，AMPK 是一种参与调节细胞能量代谢的丝氨酸/苏氨酸蛋白激酶，可导致癌细胞中 mTOR 信号传导和蛋白质合成的减少。
  42. GC60241 Melatonin D5

    褪黑素 D5; N-Acetyl-5-methoxytryptamine-d4

     An internal standard for the quantification of melatonin
  43. GC60159 Ezetimibe ketone

    (3R,4S)-1-(4-氟苯基)-3-[3-(4-氟苯基)-3-氧代丙基]-4-(4-羟基苯基)氮杂环丁烷-2-酮,EZM-K

     Ezetimibe ketone (EZM-K) 是 Ezetimibe 的 I 期代谢产物。Ezetimibe 是一种 NPC1L1 抑制剂，是有效的 Nrf2 激活剂，Ezetimibe 还是有效的胆固醇吸收抑制剂。
  44. GC60076 Bigelovin

    锦菊素

     Bigelovin是可从海百合中分离得到的一种倍半萜内酯，是选择性的视黄素X受体α(retinoidXreceptorα)的激动剂。Bigelovin可通过诱导凋亡和自噬来发挥抗肿瘤活性。Bigelovin通过抑制ROS的生成来调节mTOR信号通路。
  45. GC39658 4,4'-Dimethoxychalcone

    4,4'-甲氧基查耳酮

     4,4'-Dimethoxychalcone 可从植物当归中分离得到，是一种天然自噬 (autophagy) 诱导剂，具有抗衰老活性。
  46. GC39612 Imatinib D8

    伊马替尼D8,STI571-d8; CGP-57148B-d8

     Imatinib D8 (STI571 D8) 是 Imatinib (STI571) 的氘代物。Imatinib 是一种口服生物可用的酪氨酸激酶抑制剂，可选择性抑制 BCR/ABL，v-Abl，PDGFR，c-kit 激酶活性。
  47. GC39530 TFEB activator 1

    (1E,4E)-1,5-二(2-甲氧基)-1,4-二烯基-3-戊酮,Curcumin analog C1

     A synthetic curcuminoid and activator of TFEB
  48. GC39481 BL-918 An ULK1 activator
  49. GC39450 Tea polyphenol

    茶多酚

     Tea polyphenols are chemical compounds such as flavanoids and tannins found naturally in tea. Several biological properties have been associated to tea polyphenols (TP), including antioxidant, anti-carcinogenic and antimicrobial activities.
  50. GC39411 NL-1 The mitochondrial mitoNEET ligand NL-1 is a mitoNEET inhibitor, which induces a concentration-dependent decrease in cell viability with an IC50 of 47.35 μM and 56.26 μM in REH and REH/Ara-C cells respectively. The docking studies using liver mitochondrial suspensions show the IC50 of NL-1 binding for [3H]-rosiglitazone is 0.9 μM and the Ki for NL-1 site 1 and site 2 was 4.78 and 2.77, respectively.
  51. GC39395 LC3-mHTT-IN-AN1 An LC3B-mutant huntingtin linker

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