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Home >> Signaling Pathways >> Ubiquitination/ Proteasome >> Autophagy

Autophagy(自噬)

Autophagy is a catabolic process which degrades and recycles long-lived proteins and cytoplasmic organelles through lysosome. It plays an important role in growth regulation and maintenance of homeostasis.

Products for  Autophagy

  1. Cat.No. 产品名称 Information
  2. GC63316 Ammonium chloride

    氯化铵

     Ammonium chloride is an inorganic compound and can be used for establishing the rat model of renal calcium oxalate calculus, it is also an autophagy inhibitor.
  3. GC62881 CA77.1 CA77.1 (CA) is a potent, brain-penetrant and orally active activator of chaperone-mediated autophagy (CMA) for the treament of Alzheimer's disease (AD).
  4. GC62853 Aumitin Aumitin 是一种基于二氨基嘧啶的自噬抑制剂，通过靶向复合物 I 抑制线粒体呼吸。Aumitin 以剂量依赖性抑制饥饿和雷帕霉素诱导的自噬，IC50 分别为 0.12 μM 和 0.24 μM。
  5. GC49341 Spermidine-d6 An internal standard for the quantification of spermidine
  6. GC49308 Ungeremine

    石蒜碱内铵盐

     A betaine-type alkaloid with diverse biological activities
  7. GC49189 (E/Z)-4-hydroxy Tamoxifen-d5

    Afimoxifene-d5, 4-OHT-d5

     An internal standard for the quantification of (E/Z)-4-hydroxy tamoxifen
  8. GC49084 PHY34 An inhibitor of late-stage autophagy
  9. GC49016 Dimethyl 2-ketoglutarate

    alpha-酮戊二酸二甲酯

     An esterified form of α-ketoglutarate
  10. GC62630 TAS-117 hydrochloride

    TAS-117 hydrochloride

     TAS-117 hydrochloride 是一种有效、选择性、具有口服活性的别构 Akt 抑制剂 (对 Akt1、2 和 3 的 IC50 分别为 4.8、1.6 和 44 nM)。TAS-117 hydrochloride 激发抗骨髓瘤活性并增强蛋白酶体抑制诱导的致命内质网应激。TAS-117 hydrochloride 诱导细胞凋亡 (apoptosis) 和自噬 (autophagy)。
  11. GC62626 ICCB-19 hydrochloride ICCB-19 hydrochloride is an inhibitor of TNFRSF1A Associated Via Death Domain (TRADD) with IC50 of 1.12 μM and 2.01 μM for protecting Velcade-induced apoptosis in Jurkat cells and protecting RDA in MEFs, respectively. ICCB-19 indirectly inhibits Receptor-interacting serine/threonine-protein kinase 1 (RIPK1). ICCB-19 effectively induces autophagy.
  12. GC62564 Mito-LND

    Mito-Lonidamine

     Mito-LND (Mito-Lonidamine) 是一种具有口服活性的且靶向线粒体的氧化磷酸化 (oxidative phosphorylation (OXPHOS)) 抑制剂。Mito-LND 抑制线粒体生物能，刺激活性氧 (reactive oxygen species) 的形成，并诱导肺癌细胞自噬细胞死亡。
  13. GC62528 (Rac)-Hesperetin

    3′,5,7-三羟基-4-甲氧基黄酮

     (Rac)-Hesperetin 是Hesperetin 的外消旋体。 Hesperetin 是一种天然黄烷酮类物质，为有效的，广谱的人 UGT 抑制剂。Hesperetin 可通过激活 p38 MAPK 来诱导凋亡。
  14. GC62465 Idelalisib D5

    CAL-101 D5; GS-1101 D5

     Idelalisib D5 (CAL-101 D) 是 Idelalisib 的一种氘代化合物。Idelalisib 是一种口服有效的高选择性 p110δ 抑制剂。
  15. GC62339 mTOR inhibitor-8 mTOR inhibitor-8 是一种 mTOR 抑制剂和自噬 (autophagy) 诱导剂。mTOR inhibitor-8 通过 FKBP12 抑制 mTOR 活性，并诱导 A549 人肺癌细胞自噬。
  16. GC62309 AS1708727 AS1708727 是口服有效的 Foxo1 抑制剂，其对 G6Pase 和 PEPCK 的 EC50 值分别为 0.33 μM 和0.59 μM。
  17. GC62203 Falcarindiol

    法卡林二醇

     Falcarindiol (FAD, (3R,8S)-Falcarindiol, FaDOH) is a natural polyacetylene compound found rich in many plants of the Umbelliferae family. Falcarindiol suppresses LPS-stimulated expression of inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β). Falcarindiol attenuates the LPS-induced activation of JNK, ERK, STAT1, and STAT3 signaling molecules.
  18. GC61865 Cearoin

    2,5-二羟基-4-甲氧基二苯甲酮

     Cearoin 通过促进 ROS 产生和激活 ERK 来增强自噬 (autophagy) 和诱导细胞凋亡(apoptosis)。
  19. GC19766 Heparin sodium salt (MW 15kDa)

    肝素钠 (MW 15kDa); Sodium heparin (MW 15kDa); Sodium heparinate (MW 15kDa)

     肝素钠盐（MW 15kDa）（Sodium heparin (MW 15kDa)）是肝素的聚合物，分子量为15kDa。
  20. GC61809 Olanzapine D3

    奥氮平 D3; LY170053-d3

     OlanzapineD3(LY170053D3)是Olanzapine的氘代物。Olanzapine是一种选择性单胺能拮抗剂，高亲和力结合5-羟色胺H1，5HT2A/2C，5HT3，5HT6(Ki分别为7、4、11、57和5nM)，多巴胺D1-4(Ki=11-31nM)，毒蕈碱M1-5(Ki=1.9-25nM)和肾上腺素α1受体(Ki=19nM)。Olanzapine是一种非典型的抗精神病剂。
  21. GC61669 Ethyl 3,4-dihydroxybenzoate

    3,4-二羟基苯甲酸乙酯,Ethyl protocatechuate

     Ethyl3,4-dihydroxybenzoate(Ethylprotocatechuate)是一种抗氧化剂，是一种在花生种子的种皮中发现的脯氨酰羟化酶(prolyl-hydroxylase)抑制剂。Ethyl3,4-dihydroxybenzoate通过激活NO合酶(NOsynthase)并产生线粒体ROS来保护心肌。Ethyl3,4-dihydroxybenzoate可诱导ESCC细胞自噬(autophagy)和凋亡(apoptosis)。Ethyl3,4-dihydroxybenzoate是胶原蛋白合成抑制剂，具有骨骼保护作用。
  22. GC61565 Indophagolin

    5-溴-N-(4-氯-3-(三氟甲基)苯基)-1-(环丙烷羰基)吲哚啉-6-磺酰胺

     Indophagolin, a potent indoline-containing autophagy inhibitor with IC50 of 140 nM, antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively, also has a strong antagonistic effect on serotonin receptor 5-HT6 with IC50 of 1.0 μM.
  23. GC61521 Calmodulin-Dependent Protein Kinase II(290-309) acetate Calmodulin-DependentProteinKinaseII(290-309)acetate是有效的CaMK拮抗剂，抑制抑制Ca2+/钙调蛋白依赖性蛋白激酶II的IC50值为52nM。
  24. GC61520 Cilengitide TFA

    EMD 121974 TFA

     An integrin αVβ3 receptor antagonist
  25. GC61472 Zingiberene

    α-Zingiberene; (-)-Zingiberene

     Zingiberene(α-Zingiberene)是一种单环倍半萜烯，是姜油的主要成分。具有神经保护潜能。Zingiberene能诱导自噬(autophagy)。具有抗癌活性。
  26. GC19729 Adenosine 5′-diphosphoribose sodium

    二磷酸腺苷核糖; ADP ribose sodium

     Adenosine 5'-diphosphoribose sodium (ADP ribose sodium) 是一种烟酰胺腺嘌呤核苷酸 (NAD+) 代谢物。
  27. GC48689 SBP-7455 A dual inhibitor of ULK1 and ULK2
  28. GC48676 Monascuspiloin

    Monascinol

     A fungal metabolite with anticancer activity
  29. GC19569 Hydroquinone

    1,4-苯二酚,Quinol

  30. GC48124 Tamoxifen-d5

    ICI 47699-?d5; (Z)-Tamoxifen-?d5; trans-Tamoxifen-?d5

     An internal standard for the quantification of tamoxifen
  31. GC48118 Sunitinib-d10

    舒尼替尼-D10,SU 11248-d10

     An internal standard for the quantification of sunitinib
  32. GC48052 Rilmenidine-d4

    Oxaminozoline-d4

     An internal standard for the quantification of rilmenidine
  33. GC48027 Rapamycin-d3

    三氘代雷帕霉素,Sirolimus-d3; AY-22989-d3

     An internal standard for the quantification of rapamycin
  34. GC47735 N-acetyl Desethylchloroquine-d4

    N-acetyl-(mono) Desethylchloroquine

     An internal standard for the quantification of N-acetyl desethylchloroquine
  35. GC47470 Isovaleryl-L-carnitine-d3 (chloride)

    CAR 5:0-d3, C5:0 Carnitine-d3, L-Carnitine isovaleryl ester-d3, L-Isovalerylcarnitine-d3

     A neuropeptide with diverse biological activities
  36. GC47445 Hydroxychloroquine-d4 (sulfate)

    HCQ-d4 sulfate

     An internal standard for the quantification of hydroxychloroquine
  37. GC47436 HT-2 Toxin-13C22

    HT-2毒素-13C22溶液

     An internal standard for the quantification of HT-2 toxin
  38. GC47408 Glycochenodeoxycholic Acid-d4

    甘氨鹅脱氧胆酸-D4,Chenodeoxycholylglycine-d4

     An internal standard for the quantification of glycochenodeoxycholic acid
  39. GC47407 Glycochenodeoxycholic Acid (sodium salt hydrate)

    GCDCA, NSC 681056

     A neuropeptide with diverse biological activities
  40. GC47303 Erlotinib-d6 (hydrochloride)

    埃罗替尼-D6盐酸盐,CP-358774-d6 hydrochloride; NSC 718781-d6 hydrochloride; OSI-774-d6 hydrochloride

     An internal standard for the quantification of erlotinib
  41. GC47284 Elaidic Acid-d17

    C18:1(9E)-d17, 9(E)-Oleic Acid-d17, trans-Oleic Acid-d17

     A neuropeptide with diverse biological activities
  42. GC47195 Desethylchloroquine-d4

    N-Desethylchloroquine-d4

     An internal standard for the quantification of desethylchloroquine
  43. GC47194 Desethylchloroquine

    羟基氯喹EP杂质D-d5二盐酸

     An active metabolite of chloroquine
  44. GC47193 Desethyl Hydroxychloroquine-d4

    Desethylhydroxychloroquine-d4

     An internal standard for the quantification of desethyl hydroxychloroquine
  45. GC47065 CAY10773 A derivative of sorafenib
  46. GC47016 Cabergoline-d6

    FCE-21336-d6

     A neuropeptide with diverse biological activities
  47. GC46989 C18 dihydro Ceramide-d3 (d18:0/18:0-d3)

    N-octadecanoyl-D-erythro-Dihydrosphingosine-d3

     An internal standard for the quantification of C18 dihydro ceramide
  48. GC46923 Bexarotene-d4

    LGD1069 D4

     A neuropeptide with diverse biological activities
  49. GC46897 AUTEN-99

    Autophagy enhancer-99 hydrobromide

     An inhibitor of MRMR14/Jumpy
  50. GC61263 Salvigenin

    三裂鼠尾草素

     A polyphenol flavonoid with diverse biological activities
  51. GC61256 Rupatadine D4 fumarate

    UR-12592 D4 fumarate

     RupatadineD4fumarate(UR-12592D4fumarate)是Rupatadinefumarate的氘代标记物。RupatadineFumarate(UR-12592Fumarate)富马酸盐是PAF/H1受体双抑制剂，Ki值分别为0.55μM和0.1μM。

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