Search Site
  • 0
    My Cart

    Click Here to Find How Many Items You Have Added:)

qq在线咨询
Home >> Signaling Pathways >> Ubiquitination/ Proteasome >> Autophagy

Autophagy(自噬)

Autophagy is a catabolic process which degrades and recycles long-lived proteins and cytoplasmic organelles through lysosome. It plays an important role in growth regulation and maintenance of homeostasis.

Products for  Autophagy

  1. Cat.No. 产品名称 Information
  2. GC36868 Pennogenin 3-O-beta-chacotrioside

    偏诺皂苷元-3-O-Α-L-吡喃鼠李糖-(1→4)[Α-L-吡喃鼠李糖基](1→2)-Β-D-葡萄糖苷

     Pennogenin 3-O-beta-chacotrioside, an active component isolated from Paris polyphylla, modulates autophagy via increasing the expressions of autophagy-related proteins LC3 and Beclin-1, and posesses anti-colorectal cancer activity.
  3. GC36855 Paris saponin VII

    重楼皂苷 VII; Chonglou Saponin VII

     Chonglou Saponin VII (Dioscinin, Polyphyllin-VII, Paris saponin-VII), a kind of steroidal saponins from Chonglou (Rhizoma Paridis Chonglou), inhibits EMT and reduces the invasion of ovarian cancer cells via the GSK-3β/β-catenin signaling pathway.
  4. GC36848 Pantoprazole sodium hydrate

    泮托拉唑钠水合物; BY1023 sodium hydrate; SKF96022 sodium hydrate

     A proton pump inhibitor
  5. GC36847 Pantoprazole sodium

    泮托拉唑钠; BY1023 sodium; SKF96022 sodium

     A proton pump inhibitor
  6. GC36821 OSU-T315 OSU-T315 (ILK-IN-2) is a potent Integrin-Linked Kinase (ILK) inhibitor with IC50 of 0.6 μM. OSU-T315 induces autophagy and apoptosis, both of which are integral to its antiproliferative activity. OSU-T315 exhibits anti-tumor activity.
  7. GC36806 Omeprazole D3

    奥美拉挫 D3; H 16868-d3

     An internal standard for the quantification of omeprazole
  8. GC36758 Norepinephrine hydrochloride

    去甲肾上腺素盐酸盐; Levarterenol hydrochloride; L-Noradrenaline hydrochloride

    A racemic mixture of of L-norepinephrine and D-norepinephrine
  9. GC36736 Nicodicosapent Nicodicosapent 是一种脂肪酸烟酸共轭体，可以抑制固醇调节元件结合蛋白 (SREBP) 的活性，调节胆固醇代谢的蛋白质如 PCSK9，HMG-CoA reductase，ATP citrate lyase 和 NPC1L1 等的活性。
  10. GC36703 N-Benzyloleamide

    N-苄基-9顺-油酸酰胺

     N-Benzyloleamide 是从 Lepidium meyenii (Maca) 中分离出的一种 maccamide。N-Benzyloleamide 不可逆地抑制脂肪酸酰胺水解酶 (FAAH)。N-Benzyloleamide 影响能量代谢，显示抗氧化和抗疲劳活性。
  11. GC36690 Nampt-IN-3 Nampt-IN-3 (Compound 35) 同时抑制烟酰胺磷酸核糖转移酶 (NAMPT) 和 HDAC，IC50 分别为 31 nM 和 55 nM。Nampt-IN-3 有效诱导细胞凋亡 (apoptosis) 和自噬 (autophagy)，最终导致细胞死亡。
  12. GC36671 N-Benzyllinolenamide

    N-苄基-(9Z,12Z,15Z)-十八碳三烯酰胺

     N-?Benzyllinolenamide 是从玛卡中得到的玛卡酰胺，为脂肪酰胺水解酶 (FAAH) 抑制剂，IC50 值为 41.8 μM。
  13. GC36646 Momelotinib Mesylate

    CYT387 Mesylate

     Momelotinib Mesylate (CYT387 Mesylate) 是一种 ATP 竞争性的 JAK1/JAK2 抑制剂，IC50 值分别为 11 nM/18 nM，对其选择性约是 JAK3 的 10 倍。
  14. GC36517 LYN-1604 hydrochloride A ULK1 activator
  15. GC36479 Loperamide hydrochloride

    盐酸洛哌丁胺; R-18553 hydrochloride

     An Analytical Reference Standard
  16. GC36447 Licochalcone E

    甘草查尔酮E

     Licochalcone E 是可从Glycyrrhiza inflate 中提取到的黄酮类化合物，通过抑制AKT 和 MAPK 的激活来抑制NF-κB 和 AP-1 的转录活性。
  17. GC36427 Lasalocid sodium

    拉沙洛西钠; Lasalocid-A sodium; Ionophore X-537A sodium; Antibiotic X-537A sodium

     An ionophore antibiotic
  18. GC36356 Ixazomib citrate

    枸橼酸艾沙佐米; MLN9708

     Ixazomib citrate (MLN9708, Ninlaro) is a prodrug of Ixazomib (MLN2238), which is a selective, orally bioavailable inhibitor of 20S proteasome that inhibits the chymotrypsin-like proteolytic (β5) site with IC50 of 3.4 nM and Ki of 0.93 nM, respectively. Ixazomib (MLN2238) also inhibits caspase-like (β1) and trypsin-like (β2) proteolytic sites with IC50 of 31 nM and 3500 nM, respectively.
  19. GC36346 Isosorbide mononitrate

    单硝酸异山梨酯; Isosorbide-5-mononitrate

     A nitric oxide donor with cardioprotective activity
  20. GC36339 Isorhapontigenin

    异丹叶大黄素

     Isorhapontigenin (ISOR), isolated from Belamcanda chinensis, is a derivative of stilbene. Isorhapontigenin possessed potent antioxidative activity. Isorhapontigenin suppresses interleukin-1β-induced inflammation and cartilage matrix damage in rat chondrocytes.
  21. GC36329 Irinotecan hydrochloride

    伊立替康盐酸盐; (+)-Irinotecan hydrochloride; CPT-11 hydrochloride

     A potent inhibitor of DNA topoisomerase I
  22. GC36215 Heparin Lithium salt

    肝素锂

    Heparin Lithium salt 是一种抗凝剂，可与 抗凝血酶III (ATIII) 可逆地结合 (50-400 U/Kg)。
  23. GC36163 Glycycoumarin

    甘草香豆素

     Glycycoumarin 是一种甘草中主要的生物活性香豆素。Glycycoumarin 通过激活自噬，抑制内质网应激介导的 JNK 和 GSK-3 介导的线粒体途径，来抑制肝细胞脂性凋亡。Glycycoumarin 能直接靶向 T-LAK 细胞源蛋白激酶发挥抗肝癌活性 。
  24. GC36149 GLPG2451 GLPG2451 是一种囊性纤维化跨膜电导调节器 (CFTR) 的增强剂，有效增强低温挽救的 F508del CFTR，EC50 为 11.1 nM。
  25. GC36136 Ginkgolide K

    银杏内酯 K

     A terpene trilactone with diverse biological activities
  26. GC36130 Gemcitabine elaidate

    反油酸吉西他滨; CP-4126; CO-101; Gemcitabine 5'-elaidate

     A prodrug form of gemcitabine
  27. GC36063 FMK 9a FMK 9a是autophagin-1的抑制剂，在FRET和LRA试验中测定的IC50值分别为80 和73 nM。
  28. GC36061 Fluvastatin D6 sodium

    氟伐他汀钠D6; XU 62-320 (D6)

     An internal standard for the quantification of fluvastatin
  29. GC36023 FAAH inhibitor 1

    Benzothiazole analog 3

     FAAH inhibitor 1是脂肪酸酰胺水解酶（FAAH）抑制剂，IC50为18 nM。
  30. GC36003 Erlotinib mesylate

    埃罗替尼甲磺酸盐; CP-358774 mesylate; NSC 718781 mesylate; OSI-774 mesylate

     An EGFR tyrosine kinase inhibitor
  31. GC35998 Episilvestrol Episilvestrol 是 silvestrol 的衍生物，从 Aglaia silvestris 中分到，能够抑制 eIF4A 靶作用的转录过程。
  32. GC35982 EN6 An activator of autophagy
  33. GC35969 eIF4A3-IN-1 eIF4A3-IN-1 (compound 53a) 是一种选择性的真核起始因子 4A3 (eIF4A3) 抑制剂 (IC50=0.26 μM; Kd=0.043 μM)，eIF4A3-IN-1 与 eIF4A3 的非 ATP 结合位点结合，并在 10 μM 和 3 μM 时明显抑制细胞无义介导的 RNA 衰变 (NMD), 可作为进一步研究 eIF4A3、外显子连接复合体 (EJC) 和 NMD 的探针。
  34. GC35832 Dehydrocorydaline chloride

    盐酸脱氢紫堇碱; 13-Methylpalmatine chloride

     An alkaloid with diverse biological activities
  35. GC35820 DDD107498 succinate

    DDD107498 succinate; DDD-498 succinate; M5717 succinate

     DDD107498 (M-5717, DDD-498) is a P. falciparum translation elongation factor 2 inhibitor. DDD107498 exhibits a potent and novel spectrum of antimalarial activity against multiple life-cycle stages of the Plasmodium parasite.
  36. GC35812 Dasatinib hydrochloride

    达沙替尼盐酸盐; BMS-354825 hydrochloride

     An inhibitor of Abl and Src
  37. GC35668 CG-200745

    CG-200745

     CG-200745 (CG-200745) 是一种具有口服活性的强效 pan-HDAC 抑制剂，其异羟肟酸部分可与催化袋底部的锌结合。 CG-200745 抑制组蛋白 H3 和微管蛋白的去乙酰化。 CG-200745 诱导 p53 的积累，促进 p53 依赖性反式激活，并增强 MDM2 和 p21 (Waf1/Cip1) 蛋白的表达。 CG-200745 增强了吉西他滨耐药细胞对吉西他滨和 5-氟尿嘧啶 (5-FU;) 的敏感性。 CG-200745 诱导细胞凋亡并具有抗肿瘤作用。
  38. GC35667 CFTR corrector 1

    VX-445

     An F508del-CFTR corrector and potentiator
  39. GC35613 Carvedilol phosphate hemihydrate

    卡维地洛磷酸盐,BM 14190 phosphate hemihydrate

     A β-adrenergic receptor antagonist
  40. GC35601 CaMKII-IN-1

    3-氯-2-甲基-N-[5,6,7,8-四氢-2-[(2-苯基乙基)氨基]-6-(苯基甲基)吡啶并[4,3-D]嘧啶-4-基]苯磺酰胺

     CaMKII-IN-1是CaMKII高效选择性抑制剂，IC50值为63nM,对CaMKIV, MLCK, p38a, Akt1,和PKC几乎无作用。
  41. GC35555 Britannin

    旋覆花内酯

     Britannin，分离于 Inula aucheriana，是倍半萜内酯。Britannin 通过激活由 ROS 调节的 AMPK 来诱导肝癌细胞凋亡和自噬。Britannin 具有抗增殖和抗炎活性。
  42. GC35554 Brevilin A

    短叶老鹳草素A

     A sesquiterpene lactone with anticancer activity
  43. GC35509 BGT226

    NVP-BGT226

     BGT226 (NVP-BGT226) maleate is a novel class I PI3K/mTOR inhibitor for PI3Kα/β/γ with IC50 of 4 nM/63 nM/38 nM. Phase 1/2.
  44. GC35497 Berberine chloride hydrate

    盐酸黄连素水合物; Natural Yellow 18 chloride hydrate

     As isoquinoline alkaloid with diverse biological activities
  45. GC35462 Bafetinib

    巴氟替尼; INNO-406; NS-187

     A Bcr-Abl inhibitor
  46. GC35445 Azathramycin

    去甲基阿奇霉素; Azaerythromycin A; Desmethyl Azithromycin

     Azathramycin (Azaerythromycin A, Azaerythromycin) is a macrolide antibiotic containing cladinose.
  47. GC35434 Autogramin-2 Autogramin-2 有效抑制由饥饿诱导的自噬 (autophagy)，IC50 为 0.27 μM。Autogramin-2 也抑制 Rapamycin (通过抑制 mTORC1) 诱导的自噬 (autophagy)，IC50 为 0.14 μM。
  48. GC35433 Autogramin-1 Autogramin-1 有效抑制由饥饿诱导的自噬 (autophagy)，IC50 为 0.17 μM。Autogramin-1 也抑制 Rapamycin (通过抑制 mTORC1) 诱导的自噬 (autophagy)，IC50 为 0.44 μM。
  49. GC35432 Autocamtide-2-related inhibitory peptide (TFA) A CaMKII inhibitor
  50. GC35419 Atorvastatin

    阿托伐他汀

    阿托伐他汀（Atorvastatin）是一种口服活性HMG-CoA还原酶抑制剂，可以有效降低血脂
  51. GC35322 Amiodarone

    胺碘酮

     Amiodarone (NSC 85442,Amiodar,Amiodarone hydrochloride,Nexterone) HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias.

Items 201 to 250 of 1114 total

per page
  2. 3
  3. 4
  4. 5
  5. 6
  6. 7

Set Descending Direction