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Home >> Signaling Pathways >> Ubiquitination/ Proteasome >> Autophagy

Autophagy(自噬)

Autophagy is a catabolic process which degrades and recycles long-lived proteins and cytoplasmic organelles through lysosome. It plays an important role in growth regulation and maintenance of homeostasis.

Products for  Autophagy

  1. Cat.No. 产品名称 Information
  2. GC38451 S29434

    NMDPEF

     S29434 (NMDPEF) 是一种有效、竞争性、选择性、可透过细胞膜的醌还原酶 2 (quinone reductase 2 (QR2)) 抑制剂，在不同的组织层面，对人 QR2 的 IC50 值为 5-16 nM，对其选择性高于 QR1。S29434 (NMDPEF) 可诱导自噬 (autophagy)，抑制 QR2 介导的 ROS 的产生。
  3. GC38437 Fangchinoline

    防己诺林碱

     An alkaloid with diverse biological activities
  4. GC38419 Cyclovirobuxine D

    黄杨碱

     An alkaloid with diverse biological activities
  5. GC38408 Diosgenin glucoside

    延龄草苷

     A steroidal saponin with diverse biological activities
  6. GC38401 rac-AZD 6482

    2-[[1-[7-甲基-2-(吗啉-4-基)-4-氧代-4H-吡啶并[1,2-A]嘧啶-9-基]乙基]氨基]苯甲酸,(Rac)-KIN-193

     rac-AZD 6482 (rac-KIN-193) 是 AZD 6482 的低活性外消旋体，AZD 6482 是一种有效的选择性 p110β 抑制剂，IC50 为 0.69 nM。
  7. GC38150 Liensinine Diperchlorate

    莲心碱高氯酸盐

     Liensinine, a major isoquinoline alkaloid, inhibits late-stage autophagy/mitophagy through blocking autophagosome-lysosome fusion. It is a novel autophagy/mitophagy inhibitor.
  8. GC45550 Pogostone

    广藿香酮

     A pyranone with antifungal and insecticidal activities
  9. GC37886 Vandetanib trifluoroacetate

    凡德他尼,ZD6474 trifluoroacetate

     A multi-kinase inhibitor
  10. GC37885 Vancomycin

    万古霉素

     万古霉素是扰乱肠道微生物群的强效抗生素之一。
  11. GC37789 Tigecycline tetramesylate

    替加环素四甲磺酸盐; GAR-936 tetramesylate

     A glycylcycline antibiotic
  12. GC37761 Tenovin-6 Hydrochloride A small molecule activator of p53
  13. GC37694 STO-609 A CaMKK inhibitor
  14. GC37677 SRT 1720

    N-[2-[3-(1-哌嗪基甲基)咪唑并[2,1-B]噻唑-6-基]苯基]-2-喹喔啉甲酰胺

     A selective, potent SIRT1 activator
  15. GC37676 SR9011 hydrochloride A REV-ERBα/β agonist
  16. GC37669 Soyasapogenol B

    大豆甾醇B

     Soyasapogenol B，大豆的一种成分，具有抗增殖，抗转移活性。Soyasapogenol B 触发内质网应激反应，其介导结肠直肠癌中的细胞凋亡和自噬。
  17. GC37665 Sorafenib (D4)

    Bay 43-9006-d4

     Sorafenib D4 (Bay 43-9006 D4) 是 Sorafenib 氘代化合物标准品。Sorafenib 是一种多激酶抑制剂，抑制 Raf-1，B-Raf 和 VEGFR-3 的 IC50 分别为6 nM，20 nM，22 nM。
  18. GC37664 Sorafenib (D3)

    索拉非尼-D3,Bay 43-9006-d3; Donafenib

     An internal standard for the quantification of sorafenib
  19. GC37646 SKF-86002

    6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-B]-噻唑

     An anti-inflammatory agent
  20. GC37630 Sevelamer

    司维拉姆

     Sevelamer HCl is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption.
  21. GC37601 SBE13 A potent Plk1 inhibitor
  22. GC37595 SB 242235

    4-[4-(4-氟苯基)-1-(4-哌啶基)-1H-咪唑-5-基]-2-甲氧基嘧啶

     A p38α MAPK inhibitor
  23. GC37575 Ruxolitinib sulfate

    (BETAR)-BETA-环戊基-4-(7H-吡咯并[2,3-D]嘧啶-4-基)-1H-吡唑-1-丙腈硫酸盐,INCB018424 sulfate

     A potent, selective JAK1/JAK2 inhibitor
  24. GC37561 Rosuvastatin D6 Sodium An internal standard for the quantification of rosuvastatin
  25. GC37560 Rosuvastatin D6 Calcium

    瑞舒伐他汀钙 D6

     Rosuvastatin D6钙盐是Rosuvastatin的氘代化合物标准品。
  26. GC37559 Rosuvastatin D3 Sodium

    三氘代瑞舒伐他汀

     Rosuvastatin D3钠盐是Rosuvastatin氘代化合物标准品。
  27. GC36963 Pregnenolone monosulfate

    3β-Hydroxy-5-pregnen-20-one monosulfate

     Pregnenolone monosulfate 是大麻素 CB1 受体的特异性抑制剂。
  28. GC36930 Pitavastatin D4

    NK-104 D4

     Pitavastatin D4是Pitavastatin氘代化合物标准品。
  29. GC36928 Pirarubicin Hydrochloride

    盐酸吡柔比星; THP Hydrochloride

     An anthracycline antitumor antibiotic
  30. GC36879 PF-04457845

    N-哒嗪-3-基-4-(3-{[5-(三氟甲基)吡啶-2-基]醚}苯亚甲基丙酮)哌啶-1-羧酰胺

     A selective FAAH inhibitor
  31. GC36868 Pennogenin 3-O-beta-chacotrioside

    偏诺皂苷元-3-O-Α-L-吡喃鼠李糖-(1→4)[Α-L-吡喃鼠李糖基](1→2)-Β-D-葡萄糖苷

     Pennogenin 3-O-beta-chacotrioside, an active component isolated from Paris polyphylla, modulates autophagy via increasing the expressions of autophagy-related proteins LC3 and Beclin-1, and posesses anti-colorectal cancer activity.
  32. GC36855 Paris saponin VII

    重楼皂苷 VII; Chonglou Saponin VII

     Chonglou Saponin VII (Dioscinin, Polyphyllin-VII, Paris saponin-VII), a kind of steroidal saponins from Chonglou (Rhizoma Paridis Chonglou), inhibits EMT and reduces the invasion of ovarian cancer cells via the GSK-3β/β-catenin signaling pathway.
  33. GC36848 Pantoprazole sodium hydrate

    泮托拉唑钠水合物; BY1023 sodium hydrate; SKF96022 sodium hydrate

     A proton pump inhibitor
  34. GC36847 Pantoprazole sodium

    泮托拉唑钠; BY1023 sodium; SKF96022 sodium

     A proton pump inhibitor
  35. GC36821 OSU-T315

    OSU-T315 (ILK-IN-1) is a small Integrin-linked kinase (ILK) inhibitor with an IC50 of 0.6 μM, inhibiting PI3K/AKT signaling by dephosphorylation of AKT-Ser473 and other ILK targets (GSK-3β and myosin light chain).
  36. GC36806 Omeprazole D3

    奥美拉挫 D3; H 16868-d3

     An internal standard for the quantification of omeprazole
  37. GC36758 Norepinephrine hydrochloride

    去甲肾上腺素盐酸盐; Levarterenol hydrochloride; L-Noradrenaline hydrochloride

    A racemic mixture of of L-norepinephrine and D-norepinephrine
  38. GC36736 Nicodicosapent Nicodicosapent 是一种脂肪酸烟酸共轭体，可以抑制固醇调节元件结合蛋白 (SREBP) 的活性，调节胆固醇代谢的蛋白质如 PCSK9，HMG-CoA reductase，ATP citrate lyase 和 NPC1L1 等的活性。
  39. GC36703 N-Benzyloleamide

    N-苄基-9顺-油酸酰胺

     N-Benzyloleamide 是从 Lepidium meyenii (Maca) 中分离出的一种 maccamide。N-Benzyloleamide 不可逆地抑制脂肪酸酰胺水解酶 (FAAH)。N-Benzyloleamide 影响能量代谢，显示抗氧化和抗疲劳活性。
  40. GC36690 Nampt-IN-3 Nampt-IN-3 (Compound 35) 同时抑制烟酰胺磷酸核糖转移酶 (NAMPT) 和 HDAC，IC50 分别为 31 nM 和 55 nM。Nampt-IN-3 有效诱导细胞凋亡 (apoptosis) 和自噬 (autophagy)，最终导致细胞死亡。
  41. GC36671 N-Benzyllinolenamide

    N-苄基-(9Z,12Z,15Z)-十八碳三烯酰胺

     N-?Benzyllinolenamide 是从玛卡中得到的玛卡酰胺，为脂肪酰胺水解酶 (FAAH) 抑制剂，IC50 值为 41.8 μM。
  42. GC36646 Momelotinib Mesylate

    CYT387 Mesylate

     Momelotinib Mesylate (CYT387 Mesylate) 是一种 ATP 竞争性的 JAK1/JAK2 抑制剂，IC50 值分别为 11 nM/18 nM，对其选择性约是 JAK3 的 10 倍。
  43. GC36517 LYN-1604 hydrochloride A ULK1 activator
  44. GC36479 Loperamide hydrochloride

    盐酸洛哌丁胺; R-18553 hydrochloride

     An Analytical Reference Standard
  45. GC36447 Licochalcone E

    甘草查尔酮E

     Licochalcone E 是可从Glycyrrhiza inflate 中提取到的黄酮类化合物，通过抑制AKT 和 MAPK 的激活来抑制NF-κB 和 AP-1 的转录活性。
  46. GC36427 Lasalocid sodium

    拉沙洛西钠; Lasalocid-A sodium; Ionophore X-537A sodium; Antibiotic X-537A sodium

     An ionophore antibiotic
  47. GC36356 Ixazomib citrate

    枸橼酸艾沙佐米; MLN9708

     Ixazomib citrate (MLN9708, Ninlaro) is a prodrug of Ixazomib (MLN2238), which is a selective, orally bioavailable inhibitor of 20S proteasome that inhibits the chymotrypsin-like proteolytic (β5) site with IC50 of 3.4 nM and Ki of 0.93 nM, respectively. Ixazomib (MLN2238) also inhibits caspase-like (β1) and trypsin-like (β2) proteolytic sites with IC50 of 31 nM and 3500 nM, respectively.
  48. GC36346 Isosorbide mononitrate

    单硝酸异山梨酯; Isosorbide-5-mononitrate

     A nitric oxide donor with cardioprotective activity
  49. GC36339 Isorhapontigenin

    异丹叶大黄素

     Isorhapontigenin (ISOR), isolated from Belamcanda chinensis, is a derivative of stilbene. Isorhapontigenin possessed potent antioxidative activity. Isorhapontigenin suppresses interleukin-1β-induced inflammation and cartilage matrix damage in rat chondrocytes.
  50. GC36329 Irinotecan hydrochloride

    伊立替康盐酸盐; (+)-Irinotecan hydrochloride; CPT-11 hydrochloride

     A potent inhibitor of DNA topoisomerase I
  51. GC36215 Heparin Lithium salt

    肝素锂

    Heparin Lithium salt 是一种抗凝剂，可与 抗凝血酶III (ATIII) 可逆地结合 (50-400 U/Kg)。

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