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Home >> Signaling Pathways >> Ubiquitination/ Proteasome >> Autophagy

Autophagy(自噬)

Autophagy is a catabolic process which degrades and recycles long-lived proteins and cytoplasmic organelles through lysosome. It plays an important role in growth regulation and maintenance of homeostasis.

Products for  Autophagy

  1. Cat.No. 产品名称 Information
  2. GC35268 AGN 205728 AGN 205728是选择性RARγ拮抗剂，Ki/IC95分别为3 nM/ 0.6 nM，对RARα和RARβ无抑制性。
  3. GC35267 AGN 205327 AGN 205327是RAR激动剂，对RARα/β/γ的EC50分别为3766/734/32 nM，对RXR无抑制性。
  4. GC35266 AGN 196996 AGN 196996是高活性RARα选择性抑制剂，Ki为2 nM，对RARβ和RARγ的亲和性极低（Ki分别为1087 nM和8523 nM）。
  5. GC35265 AGN 195183

    IRX-5183; VTP-195183; NRX-195183

     AGN 195183是RARα选择性激动剂，Kd为3 nM，相对于AGN 193836有更好的结合选择性，对RARβ/γ无活性。
  6. GC35262 Afzelin

    阿福豆苷,Kaempferol-3-O-rhamnoside

     A polyphenolic glycoside flavone with diverse biological activities
  7. GC35242 Actein

    黄肉楠碱

     Actein 是从 Cimicifuga foetida 的根茎中分离的三萜糖苷。Actein 通过促进 ROS/JNK 活化和钝化人膀胱癌中的 AKT 途径来抑制细胞增殖，诱导自噬和凋亡。Actein 在体内几乎没有毒性。
  8. GC35228 Aceglutamide

    乙酰谷酰胺; α-N-Acetyl-L-glutamine; N2-Acetylglutamine

     An acetylated form of L-glutamine
  9. GC35211 A-317491 sodium salt hydrate A P2X3 and P2X2/3 receptor antagonist
  10. GC35132 4-Hydroxylonchocarpin

    异补骨脂色烯查耳酮

     4-Hydroxylonchocarpin 是一种查尔酮化合物，来自补骨脂 (Psoralea corylifolia) 提取物。4-Hydroxylonchocarpin 增强 p38 MAPK，JNK 和 ERK 的磷酸化。4-Hydroxylonchocarpin 具有多种药理活性，包括抗菌，抗癌，抗逆转录酶，抗结核，抗疟，抗炎和抗氧化活性。
  11. GC35112 3'-Hydroxypterostilbene

    3’-羟基紫檀茋

     3'-Hydroxypterostilbene (3'-HPT) is one of the active constituents of Sphaerophysa salsula and Pterocarpus marsupium which may be useful in treating different types of haematological malignancies. 3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells (IC50s of 9.0, 40.2, and 70.9 ?M for COLO 205, HCT-116, and HT-29 cells, respectively) by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene inhibits the PI3K/Akt/mTOR/p70S6K, and p38MAPK pathways and activates the ERK1/2, JNK1/2 MAPK pathways.
  12. GC35068 1-Monomyristin

    1-肉豆蔻酸单甘油酯

     A monoacylglycerol
  13. GC34960 (+)-Talarozole (+)-Talarozole 是视黄酸代谢的有效抑制剂，来自专利 WO 1997049704 A1。
  14. GC45187 Zoledronic Acid (hydrate)

    唑来膦酸一水合物; Zoledronate monohydrate; CGP 42446 monohydrate; CGP42446A monohydrate; ZOL 446 monohydrate

     A bisphosphonate that inhibits bone resorption
  15. GC45099 U-0126

    1,4-二氨基-2,3-二氰基-1,4-双(邻氨基苯巯基)丁二烯

    A MEK inhibitor and AMPK activator
  16. GC45064 Tomatidine (hydrochloride)

    盐酸番茄碱

     A steroidal alkaloid with diverse biological activities
  17. GC44856 Rutin (hydrate)

    芦丁三水合物; Rutoside trihydrate; Quercetin 3-O-rutinoside trihydrate

     A flavonoid glycoside with diverse biological activities
  18. GC44839 Ridaifen-B An analog of tamoxifen
  19. GC44797 Quinacrine analog 34 An autophagy inhibitor
  20. GC44680 Pregnenolone sulfate (sodium salt)

    3β-Hydroxy-5-pregnen-20-one monosulfate sodium

     A metabolite of pregnenolone
  21. GC44464 NSC 109555

    DDUG, NCI C04808

     An inhibitor of Chk2
  22. GC44400 Niclosamide (ethanolamine salt)

    氯硝柳胺乙醇胺盐,BAY2353 olamine

     氯硝柳胺是一种经美国食品和药物管理局 (FDA) 批准用于治疗肠道蛔虫感染的驱虫药。
  23. GC44346 N-Desethylamiodarone (hydrochloride)

    去乙基胺碘酮,N-desethylamiodarone hydrochloride; LB 33020 hydrochloride

     A CYP3A4 metabolite of amiodarone
  24. GC44290 NAADP (sodium salt)

    Nicotinic acid adenine dinucleotide phosphate

    A secondary messenger that induces calcium mobilization
  25. GC44059 LG 100268

    6-[1-(5,6,7,8-四氢-3,5,5,8,8-五甲基-2-萘基)环丙基]-3-吡啶羧酸,LG268

     An RXR agonist
  26. GC43999 Ketanserin (tartrate)

    酒石酸酮色林,R41468 tartrate

     A potent 5-HT2 receptor antagonist
  27. GC43922 Isovaleryl-L-carnitine (chloride)

    L-异戊酰基肉碱

     An acylcarnitine
  28. GC43599 Emetine (hydrochloride)

    盐酸吐根碱

     An alkaloid with diverse biological activities
  29. GC43359 Cytochalasin E

    细胞松弛素E

     Inhibitor of actin polymerization
  30. GC43354 Cysmethynil

    Icmt Inhibitor

     An inhibitor of protein prenylation
  31. GC43321 CPTH6 (hydrobromide) A Gcn5 and pCAF HAT inhibitor
  32. GC43265 Chromomycin A2

    色霉素A2

     An antibacterial and anticancer aureolic acid
  33. GC43105 C8 Ceramide (d18:1.8:0)

    N-辛酰基-D-神经鞘氨醇; N-Octanoyl-D-erythro-sphingosine

     A cell-permeable ceramide analog
  34. GC43048 C18 dihydro Ceramide (d18:0/18:0)

    二羟基神经酰胺,Cer(d18:0/18:0)

     A bioactive sphingolipid
  35. GC42677 ABO (hydrochloride) A modulator of annexin A7
  36. GC42414 4-hydroxy Tolbutamide

    4-羟基甲苯磺丁脲,Hydroxytolbutamide

     A CYP2C8 and CYP2C9 metabolite of tolbutamide
  37. GC41625 Oroxylin A

    千层纸素A; Baicalein 6-methyl ether; 6-Methoxybaicalein

     A flavonoid with diverse biological activities
  38. GC41308 GPP 78

    CAY10618

     Inhibitor of Nampt
  39. GC41242 Acridine Orange

    吖啶橙,NSC 194350

    Acridine Orange是一种可穿透细胞的核酸选择性荧光染料。
  40. GC40947 2,3-Dimethoxy-5-methyl-p-benzoquinone

    2,3-二甲氧基-5-甲基-1,4-苯醌,CoQ0

     An intermediate in the synthesis of ubiquinones that has anticancer activity
  41. GC40911 Glycine-β-muricholic Acid

    Gly-MCA, GβMCA

    An intestine-selective FXR antagonist
  42. GC40861 Pinosylvin

    赤松素

     A stilbene with diverse biological activities
  43. GC40793 L-erythro Sphinganine (d18:0)

    L-苏式-二氢鞘胺醇

     A bioactive sphingolipid
  44. GC40792 D-threo Sphinganine (d18:0)

    D-苏式二氢鞘氨醇

     A bioactive sphingolipid
  45. GC40775 Dexamethasone

    地塞米松; Hexadecadrol; Prednisolone F

     地塞米松是糖皮质激素家族的一员，可以保护软骨结构和功能免受关节炎相关变化的影响，包括基质丢失、炎症和软骨活力。
  46. GC40769 Asperphenamate

    Anabellamide, Auranamide, NSC 306231

     A fungal secondary metabolite
  47. GC40685 Pentoxifylline

    NSC 637086, Oxpentifylline

     Pentoxifylline is a methylxanthine derivative.
  48. GC40484 Ferulic Acid methyl ester

    阿魏酸甲酯; Methyl ferulate

     A lipophilic antioxidant
  49. GC34924 NSC 185058 An inhibitor of ATG4B
  50. GC34918 MW-150 dihydrochloride dihydrate

    MW01-18-150SRM dihydrochloride dihydrate

     An inhibitor of p38α MAPK
  51. GC34862 WYC-209

    4,5-二(羟甲基)-2-苯基-1H-咪唑

     WYC-209是一种合成类视黄醇，能抑制恶性小鼠黑色素瘤肿瘤再生细胞(TRC)的增殖，IC50值为0.19μM。WYC-209主要细胞靶点是维甲酸受体(RARs)。

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