Autophagy(自噬)

Cat.No. 产品名称 Information

GC34849 UBCS039 UBCS039 is the first synthetic SIRT6 activator with EC50 of 38 μM,induces a time-dependent activation of autophagy in several human tumor cell lines.

GC34745 PTI-428

PTI-428

Nesolicaftor (PTI-428) is a specific cystic fibrosis transmembrane conductance regulator (CFTR) amplifier that increases CFTR expression.

GC34686 Nidufexor

LMB763

An FXR partial agonist

GC34532 CFTR corrector 2 FDL169 is a CFTR corrector that is designed to fix and restore the function of the defective CFTR protein.

GC40227 Indomethacin-d4

吲哚美辛-D4; Indometacin-d4

An internal standard for the quantification of indomethacin

GC40226 Curcumin-d6

(1E,4Z,6E)-5-羟基-1,7-二[4-羟基-3-(甲氧基-D3)苯基]-1,4,6-庚三烯-3-酮,Diferuloylmethane-d6; Natural Yellow 3-d6; Turmeric yellow-d6

An internal standard for the quantification of curcumin

GC40080 Bosutinib-d8

SKI-606 D8

An internal standard for the quantification of bosutinib

GC40065 Meloxicam-d3

美洛昔康 d3

An internal standard for the quantification of meloxicam

GC40044 Zymostenol

Δ8-Cholesterol

A precursor of cholesterol

GC40007 Malformin A

Malformin A1

A cyclopentapeptide fungal metabolite with diverse biological activities

GC34390 Autocamtide 2, amide Autocamtide2,amide是钙调蛋白激酶(CaMK)家族实验的底物(100μMfinalconcentration)。

GC34330 XRK3F2 XRK3F2 is an inhibitor of the p62-ZZ domain that blunts MM-induced Runx2 suppression in vitro, and induces new bone formation and remodeling in the presence of tumor in vivo.

GC34173 LG-100064

4-[(5,6,7,8-四氢-3,5,5,8,8-五甲基-2-萘基)羰基]苯甲酸

LG-100064是一种类视黄醇X受体(retinoid-X-receptor(RXR))激动剂，对RXRα，RXRβ和RXRγ的EC50值分别为330nM，200nM和260nM；LG-100064可用于癌症研究。

GC34117 SMER18 SMER18是Rapamycin的一种小分子增强剂,充当mTOR非依赖性的的自噬诱导剂。

GC34096 (R)-(-)-Gossypol acetic acid (AT-101 (acetic acid))

(R)-(-)-醋酸棉酚; AT-101 (acetic acid); (-)-Gossypol acetic acid; (R)-Gossypol acetic acid

(R)-(-)-Gossypol (AT-101) acetic acid, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM in cell-free assays; does not inhibit BIR3 domain and BID. AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy. Phase 2.

GC34094 Mycro 3 Mycro 3 is a potent and selective inhibitor of c-Myc in whole cell assays. Mycro 3 also shows weak inhibitory activity against AP-1.

GC34072 Talmapimod (SCIO-469)

他匹莫德; SCIO-469

A p38 MAPK inhibitor

GC34057 TBHQ (tert-Butylhydroquinone)

特丁基对苯二酚; tert-Butylhydroquinone

TBHQ(tert-Butylhydroquinone)是一种强效的酚类抗氧化剂，能够减轻氧化应激和炎症反应。

GC34035 Meglutol (Dicrotalic acid)

3-羟基-3-甲基谷氨酸,Dicrotalic acid; 3-Hydroxy-3-methylglutaric acid

An HMG-CoA reductase inhibitor

GC34014 Trimetazidine dihydrochloride

盐酸曲美他嗪

An Analytical Reference Standard

GC34010 Danshensu (Dan shen suan A)

丹参素; Dan shen suan A; Salvianic acid A

丹参素是丹参的一种活性成分，通过激活 Nrf2 信号通路显示出广泛的心血管益处。

GC34009 Nitroprusside disodium dihydrate (Sodium nitroprusside dihydrate)

硝普钠二水合物; Sodium nitroprusside dihydrate; Sodium Nitroferricyanide(III) Dihydrate

Sodium Nitroprusside Dihydrate is a potent vasodilator working through releasing NO spontaneously in blood.

GC33848 Fludrocortisone acetate (9α-Fludrocortisone acetate)

醋酸氟氢可的松; 9α-Fludrocortisone acetate; 9α-Fluorcortisol acetate

A mineralocorticoid agonist

GC33833 Tetrahydrocurcumin (HZIV 81-2)

四氢姜黄素; HZIV 81-2

A metabolite of curcumin with diverse biological activities

GC33779 Cysteamine (β-Mercaptoethylamine)

巯基乙胺

2-Aminoethanethiol (cysteamine, β-Mercaptoethylamine, 2-Mercaptoethylamine, Thioethanolamine, Mercaptamine) is a radiation-protective agent that oxidizes in air to form cystamine.

GC33775 Rimacalib (SMP 114)

SMP 114

Rimacalib (SMP 114) (SMP 114) 是一种 Ca2+/钙调蛋白依赖性蛋白激酶 II (CaMKII) 抑制剂，IC50 为 ~1 μ；M 代表 CaMKIIα；至 ~30 μ；M 代表 CaMKIIγ；。

GC33732 Syntide 2 A protein kinase substrate

GC33715 Fluoxetine (LY-110140)

氟西汀; LY-110140 free base

氟西汀Fluoxetine (LY-110140)是一种具有口服活性的选择性5-羟色胺再摄取抑制剂（SSRI），常用于治疗抑郁症、强迫症、恐慌症等多种精神疾病。

GC33683 Autocamtide 2 (Autocamtide II)

Autocamtide II

Autocamtide 2 (Autocamtide II) 是钙/钙调蛋白依赖性蛋白激酶 II (CaMKII) 的高选择性肽底物。

GC33529 Sulfabenzamide (N-Sulfanilylbenzamide)

苯甲酰磺胺; N-Sulfanilylbenzamide

Sulfabenzamide (Sultrin, N-Sulfanilylbenzamide) is an antibacterial/antimicrobial which also exhibit their antitumor effects through multiple mechanisms including inhibition of membrane bound carbonic anhydrases, prevention of microtubule assembly, cell cycle arrest, and inhibition of angiogenesis.

GC33464 Oxyresveratrol (trans-Oxyresveratrol)

氧化白藜芦醇; trans-Oxyresveratrol

A resveratrol analog

GC33446 Oxyphenisatin acetate

双醋酚丁

Oxyphenisatinacetate是oxyphenisatin的前体药物，过去常用作泻药。

GC19485 DC661 A PPT1 inhibitor

GC33377 KSI-3716 KSI-3716是c-Myc的抑制剂。

GC33315 AGN 194078 AGN194078是一个有选择性的RARα激动剂，其Kd和EC50值分别为3和112nM。

GC33238 SJFδ SJFδ是一种含10个原子连接桥的PROTAC。SJFδ降解p38α，DC50为46.17nM，但不降解其他p38亚型(p38α,p38β和p38γ)。

GC33229 SJFα SJFα是一种含13个原子连接桥的PROTAC。SJFα降解p38α，DC50为7.16nM，但降解p38δ效果较差(DC50=299nM)，且在浓度高达2.5μM时也不会降解其他p38亚型(β和γ)。

GC33218 CA-5f CA-5f 是一种有效的晚期巨自噬/自噬抑制剂，通过抑制自噬体-溶酶体融合。 CA-5f 增加 LC3B-II（一种监测自噬的标志物）和 SQSTM1 蛋白，并且还增加 ROS 的产生。抗肿瘤活性。

GC33126 Lucanthone

硫蒽酮

Lucanthone is a novel autophagic inhibitor and also an orally available thioxanthone-based DNA intercalator and inhibitor of the DNA repair enzyme apurinic-apyrimidinic endonuclease 1.

GC33085 Glaucocalyxin B

蓝萼乙素

GlaucocalyxinB是从中药香茶菜中分离出来的对映-贝壳杉烷型二萜，具有抗癌和抗炎活性。24h内减少HL-60生长的IC50值约为5.86μM。

GC33008 p38 MAPK-IN-1 p38MAPK-IN-1是p38MAPK新型高效选择性抑制剂,IC50值68nM。

GC33006 CCT020312 An EIF2AK3 activator

GC33004 Cediranib maleate (AZD-2171 maleate)

西地尼布马来酸盐; AZD-2171 maleate

An inhibitor of VEGF receptor tyrosine kinases

GC33003 Daurisoline ((R,R)-Daurisoline)

蝙蝠葛苏林碱; (R,R)-Daurisoline

An alkaloid with diverse biological activities

GC32998 Ginsenoside Rh4

人参皂苷RH4

Ginsenoside Rh4 is an important active ingredient of traditional Chinese medicine ginseng, which has been shown to inhibit Wnt/β-Catenin, JAK2/STAT3, TGF-β/Smad2/3 and other signaling pathways.