Autophagy(自噬)

Cat.No. 产品名称 Information

GC44346 N-Desethylamiodarone (hydrochloride)

去乙基胺碘酮,N-desethylamiodarone hydrochloride; LB 33020 hydrochloride

A CYP3A4 metabolite of amiodarone

GC44290 NAADP (sodium salt)

Nicotinic acid adenine dinucleotide phosphate

A secondary messenger that induces calcium mobilization

GC44059 LG 100268

6-[1-(5,6,7,8-四氢-3,5,5,8,8-五甲基-2-萘基)环丙基]-3-吡啶羧酸,LG268

An RXR agonist

GC43999 Ketanserin (tartrate)

酒石酸酮色林,R41468 tartrate

A potent 5-HT₂ receptor antagonist

GC43922 Isovaleryl-L-carnitine (chloride)

L-异戊酰基肉碱

An acylcarnitine

GC43599 Emetine (hydrochloride)

盐酸吐根碱

An alkaloid with diverse biological activities

GC43359 Cytochalasin E

细胞松弛素E

Inhibitor of actin polymerization

GC43354 Cysmethynil

Icmt Inhibitor

An inhibitor of protein prenylation

GC43321 CPTH6 (hydrobromide) A Gcn5 and pCAF HAT inhibitor

GC43265 Chromomycin A2

色霉素A2

An antibacterial and anticancer aureolic acid

GC43105 C8 Ceramide (d18:1.8:0)

N-辛酰基-D-神经鞘氨醇; N-Octanoyl-D-erythro-sphingosine

A cell-permeable ceramide analog

GC43048 C18 dihydro Ceramide (d18:0/18:0)

二羟基神经酰胺,Cer(d18:0/18:0)

A bioactive sphingolipid

GC42677 ABO (hydrochloride) A modulator of annexin A7

GC42414 4-hydroxy Tolbutamide

4-羟基甲苯磺丁脲,Hydroxytolbutamide

A CYP2C8 and CYP2C9 metabolite of tolbutamide

GC41625 Oroxylin A

千层纸素A; Baicalein 6-methyl ether; 6-Methoxybaicalein

A flavonoid with diverse biological activities

GC41308 GPP 78

CAY10618

Inhibitor of Nampt

GC41242 Acridine Orange

吖啶橙,NSC 194350

Acridine Orange是一种可穿透细胞的核酸选择性荧光染料。

GC40947 2,3-Dimethoxy-5-methyl-p-benzoquinone

2,3-二甲氧基-5-甲基-1,4-苯醌,CoQ0

An intermediate in the synthesis of ubiquinones that has anticancer activity

GC40911 Glycine-β-muricholic Acid

Gly-MCA, GβMCA

An intestine-selective FXR antagonist

GC40861 Pinosylvin

赤松素

A stilbene with diverse biological activities

GC40793 L-erythro Sphinganine (d18:0)

L-苏式-二氢鞘胺醇

A bioactive sphingolipid

GC40792 D-threo Sphinganine (d18:0)

D-苏式二氢鞘氨醇

A bioactive sphingolipid

GC40775 Dexamethasone

地塞米松; Hexadecadrol; Prednisolone F

地塞米松是糖皮质激素家族的一员，可以保护软骨结构和功能免受关节炎相关变化的影响，包括基质丢失、炎症和软骨活力。

GC40769 Asperphenamate

Anabellamide, Auranamide, NSC 306231

A fungal secondary metabolite

GC40685 Pentoxifylline

NSC 637086, Oxpentifylline

Pentoxifylline is a methylxanthine derivative.

GC40484 Ferulic Acid methyl ester

阿魏酸甲酯; Methyl ferulate

A lipophilic antioxidant

GC34924 NSC 185058 An inhibitor of ATG4B

GC34918 MW-150 dihydrochloride dihydrate

MW01-18-150SRM dihydrochloride dihydrate

An inhibitor of p38α MAPK

GC34862 WYC-209

4,5-二(羟甲基)-2-苯基-1H-咪唑

WYC-209是一种合成类视黄醇，能抑制恶性小鼠黑色素瘤肿瘤再生细胞(TRC)的增殖，IC50值为0.19μM。WYC-209主要细胞靶点是维甲酸受体(RARs)。

GC34849 UBCS039 UBCS039 is the first synthetic SIRT6 activator with EC50 of 38 μM,induces a time-dependent activation of autophagy in several human tumor cell lines.

GC34745 PTI-428

PTI-428

Nesolicaftor (PTI-428) is a specific cystic fibrosis transmembrane conductance regulator (CFTR) amplifier that increases CFTR expression.

GC34686 Nidufexor

LMB763

An FXR partial agonist

GC34532 CFTR corrector 2 FDL169 is a CFTR corrector that is designed to fix and restore the function of the defective CFTR protein.

GC40227 Indomethacin-d4

吲哚美辛-D4; Indometacin-d4

An internal standard for the quantification of indomethacin

GC40226 Curcumin-d6

(1E,4Z,6E)-5-羟基-1,7-二[4-羟基-3-(甲氧基-D3)苯基]-1,4,6-庚三烯-3-酮,Diferuloylmethane-d6; Natural Yellow 3-d6; Turmeric yellow-d6

An internal standard for the quantification of curcumin

GC40080 Bosutinib-d8

SKI-606 D8

An internal standard for the quantification of bosutinib

GC40065 Meloxicam-d3

美洛昔康 d3

An internal standard for the quantification of meloxicam

GC40044 Zymostenol

Δ8-Cholesterol

A precursor of cholesterol

GC40007 Malformin A

Malformin A1

A cyclopentapeptide fungal metabolite with diverse biological activities

GC34390 Autocamtide 2, amide Autocamtide2,amide是钙调蛋白激酶(CaMK)家族实验的底物(100μMfinalconcentration)。

GC34330 XRK3F2 XRK3F2 is an inhibitor of the p62-ZZ domain that blunts MM-induced Runx2 suppression in vitro, and induces new bone formation and remodeling in the presence of tumor in vivo.

GC34173 LG-100064

4-[(5,6,7,8-四氢-3,5,5,8,8-五甲基-2-萘基)羰基]苯甲酸

LG-100064是一种类视黄醇X受体(retinoid-X-receptor(RXR))激动剂，对RXRα，RXRβ和RXRγ的EC50值分别为330nM，200nM和260nM；LG-100064可用于癌症研究。

GC34117 SMER18 SMER18是Rapamycin的一种小分子增强剂,充当mTOR非依赖性的的自噬诱导剂。

GC34096 (R)-(-)-Gossypol acetic acid (AT-101 (acetic acid))

(R)-(-)-醋酸棉酚; AT-101 (acetic acid); (-)-Gossypol acetic acid; (R)-Gossypol acetic acid

(R)-(-)-Gossypol (AT-101) acetic acid, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM in cell-free assays; does not inhibit BIR3 domain and BID. AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy. Phase 2.