Autophagy(自噬)

Cat.No. 产品名称 Information

GC32817 AGN 193109

4-[2-[5,6-二氢-5,5-二甲基-8-(4-甲基苯基)-2-萘基]乙炔基]苯甲酸

AGN193109是一种视黄酸类似物，是有效的，特异性的视黄酸受体(RARs)拮抗剂，可抑制RARα，RARβ和RARγ的活性，Kd值分别为2nM，2nM和3nM。

GC32785 ML327 ML327 is an isoxazole compound that blocks MYC expression and tumor formation in neuroblastoma. ML327 also restores E-cadherin expression with In-Cell Western EC50 of 1.0 μM. ML327 induces apoptosis.

GC32768 Quinacrine dihydrochloride (Mepacrine dihydrochloride) Quinacrine是一种荧光探针，使胆碱能受体蛋白发生构象转变，低μM水平对AML细胞具有作用活性，平均IC50为2.30μM。

GC32767 3BDO

3BDO,MTOR激酶激活剂,自噬抑制剂

A butyrolactone derivative and autophagy inhibitor

GC32762 Icaritin (Anhydroicaritin)

去水淫羊藿黄素

An FASN inhibitor

GC32742 INT-767 INT-767是法尼醇X受体/TGR5双激动剂，平均EC50分别为30和630nM。

GC32739 GCN2iB GCN2iB is an ATP-competitive serine/threonine-protein kinase general control nonderepressible 2 (GCN2) inhibitor with IC50 of 2.4 nM.

GC32731 OSU-T315 (ILK-IN-1)

OSU-T315 analog

An ILK inhibitor

GC32690 JPH203 (KYT-0353)

KYT-0353

JPH203 (KYT-0353) 是一种选择性 L 型氨基酸转运蛋白 1 抑制剂，显着抑制 HT-29 YD-38 和白血病细胞的亮氨酸摄取和细胞生长，IC50 值分别为 0.06 μM 和 4.1 μM 。

GC32468 Lanatoside C

毛花甙丙

Lanatoside C is a cardiac glycoside with antiviral and anti-tumor activity. Lanatoside C induces G2/M cell cycle arrest and induces autophagy and apoptosis via attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR signaling pathways.

GC32411 FR 167653 (FR 167653 sulfate)

FR 167653 sulfate

FR 167653 (FR 167653硫酸盐) (FR 167653 (FR 167653硫酸盐))，一种具有口服活性和选择性的p38 MAPK抑制剂，是TNF-α的强效抑制剂；和 IL-1β；通过特异性抑制 p38 MAPK 活性产生。

GC32232 Pyriproxyfen (S-31183)

吡丙醚; S-31183

A pyridine insecticide

GC32209 ITX5061 ITX5061是一个II型p38MAPK抑制剂，也是清道夫受体B1(SR-B1)的拮抗剂。

GC32152 Lumefantrine (Benflumetol)

苯芴醇; Benflumetol

An antimalarial drug

GC32107 Peretinoin (NIK333)

NIK333

Peretinoin (NIK333) 是一种具有维生素 A 样结构的口服无环类维生素 A，可靶向类维生素 A 核受体，如类维生素 X 受体 (RXR) 和视黄酸受体 (RAR)。

GC32078 Clioquinol (Iodochlorhydroxyquin)

氯碘羟喹,Iodochlorhydroxyquin

A metal-chelating antimicrobial agent

GC32048 Emetine dihydrochloride hydrate

吐根碱盐酸盐水合物

An alkaloid with diverse biological activities

GC31988 p38α inhibitor 1

p38αinhibitor1是p38α的抑制剂，来自专利WO2008076265A1。

GC31935 Trifarotene (CD5789)

曲法罗汀; CD5789

Trifarotene (CD5789) (CD5789) 是一种有效的选择性 RARγ；激动剂。

GC31924 AZD7624 AZD7624是一种可吸入的p38抑制剂，具有高效的抗炎活性。

GC31809 Yangonin

甲氧醉椒素

A kavalactone with affinity for the CB₁ receptor

GC31717 Ginkgetin

银杏双黄酮

A biflavonoid with diverse biological activities

GC31705 Sofalcone

索法酮

Gastroprotective chalcone derivative

GC31697 Dilmapimod (SB-681323)

度马莫得; SB-681323; GW 681323

Dilmapimod (SB-681323,GW 681323) is a potent p38 MAPK inhibitor that potentially suppresses inflammation in chronic obstructive pulmonary disease.

GC31665 (R)-BPO-27 (R)-BPO-27是有效的CFTR抑制剂，IC50值为4nM。

GC31586 Monacolin J (Antibiotic MB 530A)

辛伐他汀内酯二醇,Antibiotic MB 530A; Lovastatin diol lactone

Monacolin J (Antibiotic MB 530A) 是一种胆固醇生物合成抑制剂，可抑制 HMG-CoA 还原酶的活性。

GC31395 PX20606 trans racemate (PX-102 trans racemate)

CPDD1220反式消旋体,PX-102 trans racemate

PX20606 trans racemate (PX-102 trans racemate) (PX-102 trans racemate) 是一种 FXR 激动剂，在 FRET 和 M1H 试验中对 FXR 的 EC50 分别为 32 和 34 nM。

GC31386 (-)-PX20606 trans isomer ((-)-PX-102 trans isomer)

PX-20606手性,(-)-PX-102 trans isomer; (-)-PX-104

(-)-PX20606 trans isomer ((-)-PX-102 trans isomer) 是一种 FXR 激动剂，在 FRET 和 M1H 试验中对 FXR 的 EC50 分别为 18 和 29 nM。

GC31317 Sitagliptin (MK0431)

西格列汀; MK-0431

Sitagliptin (MK-0431) is an oral and highly selective DPP-4 inhibitor with an IC50 of 18 nM. It is used for the treatment of type 2 diabetes.

GC31239 SA72 SA72是高度选择性的脂肪酸酰胺水解酶(FAAH)抑制剂。

GC31170 Calmodulin-Dependent Protein Kinase II 290-309

A CaMKII inhibitor

GC31058 FR 167653 free base FR-167653是一种选择性的p38MAPK抑制剂。

GC30992 Paroxetine hydrochloride hemihydrate (BRL29060 hydrochloride hemihydrate)

盐酸帕罗西汀半水合物; BRL29060 hydrochloride hemihydrate; BRL29060A hemihydrate

Paroxetine HCl (BRL-29060A, FG-7051) is an antidepressant drug of the SSRI type.

GC30990 Calcineurin substrate

钙调神经磷酸酶底物

A synthetic peptide substrate

GC30884 LX2343 An inhibitor of BACE1 and PI3K

GC30871 Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride)

6-羟基多巴胺盐酸盐; 6-Hydroxydopamine hydrochloride; 6-OHDA hydrochloride

Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride)（6-OHDA）是神经递质多巴胺的拮抗剂。

GC30842 Androsterone (5α-Androstan-3α-ol-17-one)

雄酮; 5α-Androstan-3α-ol-17-one

An androgenic steroid

GC30790 Triflupromazine hydrochloride

盐酸三氟丙嗪

A phenothiazine with diverse biological activities

GC30787 Sertindole (Lu 23-174)

舍吲哚; Lu 23-174

An atypical antipsychotic

GC30785 4E2RCat 4E2RCat是eIF4E-eIF4G相互作用的抑制剂，IC50值为13.5μM。

GC30761 α-Hydroxylinoleic acid

α-羟基油酸; α-Hydroxylinoleic acid

ABTL0812 (α-Hydroxylinoleic acid, LP-10218, SCLN-0812) inhibits Akt/mTOR axis by inducing the overexpression of TRIB3 and activating autophagy in lung squamous carcinoma cell lines. ABTL0812 also induces AMPK activation and ROS accumulation.

GC30751 FAAH-IN-1 FAAH-IN-1是脂肪酸酰胺水解酶(FAAH)抑制剂，对大鼠和人FAAH的IC50值分别为145nM和650nM。

GC30744 Norepinephrine (Adrenor)

去甲肾上腺素; Levarterenol; L-Noradrenaline

(-)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline) is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively.

GC30676 MAPK13-IN-1 MPAK13-IN-1是MAPK13(p38δ)的一个抑制剂，其IC50值为620nM。

GC30646 Skatole(3-Methylindole)

粪臭素; 3-Methylindole; 3-Methyl-1H-indole

Skatole (3-methylindole, Scatole) is a mildly toxic white crystalline organic compound that occurs naturally in feces. It has a fairly broad bacteriostatic effect.