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Home >> Signaling Pathways >> Ubiquitination/ Proteasome >> Autophagy

Autophagy(自噬)

Autophagy is a catabolic process which degrades and recycles long-lived proteins and cytoplasmic organelles through lysosome. It plays an important role in growth regulation and maintenance of homeostasis.

Products for  Autophagy

  1. Cat.No. 产品名称 Information
  2. GC30360 Cresol (Cresol mixture of isomers) Cresol是一种有机化合物，是芳香族有机化合物广泛存在的天然及合成基团。
  3. GC30356 Metofenazate (Methophenazine)

    美托奋乃酯,Methophenazine

     Metofenazate (Methophenazine) 是一种选择性钙调蛋白抑制剂。
  4. GC30343 Selenomethionine (Seleno-DL-methionine)

    硒代蛋氨酸; Seleno-DL-methionine; DL-Selenomethionine

    硒代蛋氨酸（Seleno-DL-methionine）是一种天然存在的含硒氨基酸，是硒的常见天然食物来源。
  5. GC30263 Glucosamine (D-Glucosamine)

    氨基葡萄糖; D-Glucosamine; Chitosamine

     Glucosamine (2-amino-2-deoxy-D-glucose) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. It is commonly used as a treatment for osteoarthritis. Glucosamine（GS） treatment selectively downregulates HIF-1α at the protein level in YD-8 cells via interference of production of the citric acid cycle metabolites.
  6. GC30158 p38-α MAPK-IN-1

    p38-α MAPK-IN-1 is an inhibitor of p38-α, with IC50 value of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay.
  7. GC30072 Dansylcadaverine (Monodansyl cadaverine)

    丹酰尸胺; Monodansyl cadaverine

    A fluorescent marker for autophagic vacuoles
  8. GC30056 Danthron (Dantron)

    1,8-二羟基蒽醌; Dantron; Chrysazin; 1,8-Dihydroxyanthraquinone

     Danthron (Chrysazin, Antrapurol) functions in regulating glucose and lipid metabolism by activating AMPK. Danthron is a natural product extracted from the traditional Chinese medicine rhubarb. Danthron used to be a laxativa and now is currently used as an antioxidant in synthetic lubricants, in the synthesis of experimental antitumor agents, as a fungicide and as an intermediate for making dyes.
  9. GC30054 Dantrolene sodium hemiheptahydrate (Dantrolene sodium hydrate)

    丹曲林钠,Dantrolene sodium hydrate

     Dantrolene sodium hemiheptahydrate (Dantrium) ia a skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber.
  10. GC30011 20-Deoxyingenol

    20-去氧巨大戟醇；20-去氧巨大戟萜醇

     A diterpenoid with antioxidant and osteoprotective activities
  11. GC19479 AZ304 AZ304 是一种 ATP 竞争性双 BRAF 激酶抑制剂，有效抑制野生型 BRAF、V600E 突变型 BRAF 和野生型 CRAF，IC50 分别为 79 nM、38 nM 和 68 nM。 AZ304 对其他激酶也有显着影响，例如 p38 (IC50, 6 nM)、CSF1R (IC50, 35 nM)。抗肿瘤活性。
  12. GC19453 Autophinib A VPS34 inhibitor
  13. GC19451 SBI-0640756

    SBI-756

     SBI-0640756 (SBI-756) 是 eIF4G1 的抑制剂，可破坏 eIF4F 复合物。
  14. GC19411 IITZ-01 IITZ-01 是一种有效的溶酶体自噬抑制剂，具有单剂抗肿瘤活性，对 PI3Kγ 的 IC50 为 2.62 μM。
  15. GC19421 LY2562175 An FXR agonist
  16. GC19400 JPH203 Dihydrochloride

    KYT-0353

     An inhibitor of LAT1
  17. GC19396 H 89

    N-[2-[P-溴苯丙烯盐基氨基]乙基]-5-异喹啉磺酰胺

    A PKA inhibitor
  18. GC19366 UM-164

    DAS-DFGO-II

     An inhibitor of Src and p38 MAPK kinases
  19. GC19363 Tropifexor

    LJN452

     An FXR agonist
  20. GC19325 SD 0006

    3-[N-(2-羟基乙酰基)-4-哌啶基]-4-(4-嘧啶基)-5-(4-氯苯基)吡唑,SD-06

     An inhibitor of p38α MAPK
  21. GC19304 R1487 Hydrochloride An inhibitor of p38α MAPK
  22. GC19293 PFK-158 PFK-158 是一种有效的选择性 PFKFB3 抑制剂，通过减少癌细胞中葡萄糖的摄取、ATP 的产生、乳酸的释放以及诱导细胞凋亡和自噬，显示出广泛的抗肿瘤活性.PFK-158 在 EC 细胞中以剂量和时间依赖性方式抑制细胞活力。
  23. GC19279 PD-166866 A potent inhibitor of FGFR1
  24. GC19237 Lys01 trihydrochloride

    Lys01 trihydrochloride

     An inhibitor of autophagy
  25. GC19236 LYN-1604 A ULK1 activator
  26. GC19232 LY2955303 A potent RARγ antagonist
  27. GC19188 HA15 An inhibitor of GRP78
  28. GC19169 GLPG1837

    ABBV-974

     A CFTR potentiator
  29. GC19083 Briciclib

    ON 014185

     An eIF4E inhibitor
  30. GC19040 AS1842856

    5-氨基-7-(环己基氨基)-1-乙基-6-氟-1,4-二氢-4-氧代-3-喹啉羧酸

     AS1842856是一种细胞渗透性抑制剂,抑制Foxo1转录活性,IC50=33 nM。
  31. GC19035 AR7 A RARα antagonist
  32. GC19019 Acumapimod

    BCT197

     An inhibitor of p38α MAPK
  33. GC18304 Bicyclol

    双环醇; SY801

     A hepatoprotective agent
  34. GC18269 SR 18292 SR 18292是一种过氧化物酶体增殖物激活受体γ（PPARγ）共激活因子-1α（PGC-1α）的抑制剂，可促进PGC-1α乙酰化，抑制糖异生基因的表达，并减少肝细胞中葡萄糖的产生。
  35. GC18212 Cilofexor

    GS-9674

     An FXR ligand
  36. GC18174 BIA 10-2474

    3-(1-(环己基(甲基氨基甲酰基)-1H-咪唑-4-基)吡啶1-氧化物

     An inhibitor of FAAH
  37. GC15168 Urolithin A

    尿石素A

    A metabolite of ellagic acid with diverse biological activities
  38. GC14820 (S)-Naproxen

    萘普生; (S)-Naproxen

     An NSAID and COX inhibitor
  39. GC14918 10074-G5

    N-2-联苯基-7-硝基-2,1,3-苯并恶二唑-4-胺

     An inhibitor of c-Myc/Max dimerization
  40. GC17768 Lasalocid

    那塞罗; Lasalocid-A; Ionophore X-537A; Antibiotic X-537A

     An ionophore antibiotic
  41. GC13063 N-Benzylpalmitamide

    N-苄基棕榈酰胺,N-Benzylhexadecanamide

     A long-chain fatty acid amide
  42. GC10593 BMS-582949 hydrochloride A p38α MAP kinase inhibitor
  43. GC14749 ALLO-1 A smoothened antagonist
  44. GC11989 Nortriptyline (hydrochloride)

    盐酸去甲替林; Desmethylamitriptyline hydrochloride; Desitriptilina hydrochloride

     A tricyclic antidepressant
  45. GC10133 JNJ-42165279

    N-(4-氯-3-吡啶基)-4-[(2,2-二氟-1,3-苯并二恶茂-5-基)甲基]-1-哌嗪甲酰胺

     An irreversible FAAH inhibitor
  46. GC13311 Triclosan

    三氯生

     A broad-spectrum antibacterial agent
  47. GC10331 Ebselen

    依布硒; SPI-1005; PZ-51; CCG-39161

     A peroxynitrite scavenger
  48. GC12235 Sitagliptin (phosphate)

    磷酸西他列汀; MK-0431 phosphate

     A DPP-4 inhibitor
  49. GC14591 Hemin chloride

    氯化血红素; Hemin chloride

     氯化血红素是血红素加氧酶(HO)-1的底物，可诱导多种细胞表达HO-1，发挥抗氧化和抗炎作用。
  50. GC14413 KJ Pyr 9 An inhibitor of c-Myc and v-Myc interaction with Max
  51. GC15814 Pamapimod (R-1503, Ro4402257)

    Ro4402257; R1503

     An orally bioavailable inhibitor of p38α MAP kinase

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