Mitophagy(线粒体自噬)

Mitophagy is the selective degradation of mitochondria by autophagy.

Mitochondria are essential organelles that regulate cellular energy homeostasis and cell death. The removal of damaged mitochondria through autophagy, a process called mitophagy, is thus critical for maintaining proper cellular functions. Indeed, mitophagy has been recently proposed to play critical roles in terminal differentiation of red blood cells, paternal mitochondrial degradation, neurodegenerative diseases, and ischemia or drug-induced tissue injury.

Autophagy and mitophagy are important cellular processes that are responsible for breaking down cellular contents, preserving energy and safeguarding against accumulation of damaged and aggregated biomolecules.

Products for Mitophagy

Cat.No. 产品名称 Information
GC15904 PP242
PP242; PP-242
Potent inhibitor of mTOR kinase in both mTORC1 and mTORC2
GC15617 Etoposide
依托泊苷; VP-16; VP-16-213
Etoposide（VP-16）是一种非特异性拓扑异构酶II（Topoisomerase II）抑制剂，IC₅₀值为59.2 μM。
GC13443 Doxazosin Mesylate
甲磺酸多沙唑嗪; UK 33274 mesylate
An α₁-AR antagonist
GC12339 Ivermectin
伊维菌素; MK-933
A mixture of ivermectin B_1a and ivermectin B_1b
GC15618 Melatonin
褪黑素; N-Acetyl-5-methoxytryptamine

An indoleamine neurohormone that entrains circadian rhythms
GC17567 Doxorubicin (Adriamycin) HCl
盐酸阿霉素; Hydroxydaunorubicin hydrochloride

An anthracycline antitumor antibiotic
GC14683 Sunitinib malate
苹果酸舒尼替尼,SU 11248,SU11248,SU-11248,Sunitinib
A multi-kinase inhibitor
GC13595 SB 203580
4-(4-氟苯基)-2-(4-甲基亚磺酰基苯基)-5-(4-吡啶基)-1H-咪唑,SB 203580; RWJ 64809
SB 203580是p38-MAPK（有丝分裂原活化蛋白激酶）通路的特异性抑制剂。
GC16994 Doxorubicin
阿霉素; Hydroxydaunorubicin
多柔比星（Doxorubicin，简称DOX），也被称为阿霉素，是一种蒽环类化合物，具有最广泛的活性谱。
GC10200 Mdivi 1
3-(2,4-二氯-5-甲氧基苯基)-2,3-二氢-2-硫代-4(1H)-喹唑啉酮,Mitochondrial division inhibitor 1
Mdivi-1（线粒体分裂抑制剂 1）抑制创伤性脑损伤 (TBI) 诱导的动力蛋白相关蛋白 1 (Drp1) 上调、自噬功能障碍和线粒体自噬激活。
GC14882 Salinomycin
盐霉素; Procoxacin
A selective cancer stem cell inhibitor
GC16124 Ruxolitinib phosphate
鲁索利替尼磷酸盐,INCB018424 phosphate;INCB 018424 phosphate;INCB-018424 phosphate;Ruxolitinib
A potent and selective JAK1/JAK2 inhibitor
GC17874 Matrine
苦参碱; Matridin-15-one; Vegard; α-Matrine
苦参碱（Matrine）是一种存在于槐属植物中的生物碱，可作为 kappa 阿片受体和µ-受体激动剂。
GC14787 Curcumin
姜黄素; Diferuloylmethane; Natural Yellow 3; Turmeric yellow
A yellow pigment with diverse biological activities
GC10480 Betulinic acid
白桦脂酸; Lupatic acid; Betulic acid
白桦脂酸（Betulinic acid）是一种天然的五环三萜类化合物，是真核细胞拓扑异构酶I的抑制剂，IC₅₀值为5μM。
GC15951 URB597
FAAH Inhibitor II, URB-597, URB 597, KDS-4103
An inhibitor of FAAH
GC15794 Valproic acid sodium salt (Sodium valproate)
丙戊酸钠; Sodium Valproate sodium
Valproic acid sodium salt (Sodium valproate)（VPA）是一种具有口服活性的组蛋白脱乙酰酶（HDAC）抑制剂，IC₅₀值为1.5mM，抑制HDAC1的IC₅₀值为400μM，同时可诱导HDAC2的降解。
GC14553 Resveratrol
白藜芦醇; trans-Resveratrol; SRT501
白藜芦醇（转-白藜芦醇；SRT501）是一种植物抗菌素。
GC17580 Olaparib (AZD2281, Ku-0059436)
奥拉帕尼; AZD2281; KU0059436
Olaparib (AZD2281, Ku-0059436) 是一种有效的选择性 PARP 抑制剂，特异性靶向 PARP1 和 PARP2（IC 50 分别 = 5 nM 和 1 nM）。
GC11720 17-AAG (KOS953)
坦螺旋霉素; 17-AAG; NSC 330507; CP 127374
17-AAG（格尔德霉素）是一种天然的苯醌安沙霉素抗生素，是第一个确定的 Hsp90 抑制剂。
GC17390 Vorinostat (SAHA, MK0683)
伏立诺他; SAHA; Suberoylanilide hydroxamic acid

An HDAC inhibitor
GC15706 Aspirin (Acetylsalicylic acid)
阿司匹林; Acetylsalicylic Acid; ASA
A non-selective, irreversible COX inhibitor
GC14191 Ruxolitinib (INCB18424)
芦可替尼; INCB18424

Ruxolitinib (INCB18424)作为一种抑制剂，能够抑制Janus相关激酶(JAKs)JAK1和JAK2, IC50 分别为 3.3 nM 和 2.8 nM，Ruxolitinib介导对造血和免疫功能重要的若干细胞因子和生长因子信号。
GC17234 ABT-737
ABT 737, ABT737
An inhibitor of anti-apoptotic Bcl-2 proteins
GN10257 Naringin
柚皮苷; Naringoside
A natural flavanone glycoside
GN10266 Quercetin
槲皮素

Quercetin 是一种天然类黄酮，是重组 SIRT1 的刺激剂，也是 PI3K 抑制剂，对 PI3K γ、PI3K δ 和 PI3K β 的 IC50 分别为 2.4 μM、3.0 μM 和 5.4 μM。
GN10331 Polydatin
虎杖苷; Piceid; 反式虎杖苷
A stilbene glucoside with diverse biological activities
GN10156 Ginsenoside Rb1
人参皂苷 Rb1; Gypenoside III
A triterpene saponin with diverse biological activities
GN10357 Parthenolide
小白菊内酯; (-)-Parthenolide
A natural inhibitor of NOD2 and NF-κB signaling
GC10518 AICAR
阿卡地新; Acadesine; AICA Riboside
AICAR（也称为 acadesine）是一种嘌呤核苷。
GA10942 H-D-Gln-OH
D-谷氨酰胺
H-D-Gln-OH 是一种可渗透细胞的 D 型谷氨酰胺立体异构体。
GC15083 Celastrol
雷公藤红素; Celastrol
Celastrol是一种蛋白酶体抑制剂，有效且优先的抑制纯化的20S蛋白酶体，IC₅₀ 为2.5 μM。