Resorantel
(Synonyms: 雷琐太尔) 目录号 : GC64981
Resorantel is a safe, hydroxybenzanilide cestocide highly effective against Moniezia and Thysaniezia spp. and moderately effective against Paramphistomum spp.
Cas No.:20788-07-2
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Resorantel is a safe, hydroxybenzanilide cestocide highly effective against Moniezia and Thysaniezia spp. and moderately effective against Paramphistomum spp.
| Cas No. | 20788-07-2 | SDF | Download SDF |
| 别名 | 雷琐太尔 | ||
| 分子式 | C13H10BrNO3 | 分子量 | 308.13 |
| 溶解度 | DMSO : 250 mg/mL (811.35 mM; Need ultrasonic) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.2454 mL | 16.2269 mL | 32.4538 mL |
| 5 mM | 0.6491 mL | 3.2454 mL | 6.4908 mL |
| 10 mM | 0.3245 mL | 1.6227 mL | 3.2454 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
The pharmacology of halogenated salicylanilides and their anthelmintic use in animals
J S Afr Vet Assoc 1999 Jun;70(2):61-70.PMID:10855824DOI:10.4102/jsava.v70i2.756.
The halogenated salicylanilides are a large group of compounds developed mainly for their antiparasitic activity in animals. Several halogenated salicylanilides with potent antiparasitic activity have been synthesised of which only closantel, niclosamide, oxyclozanide, rafoxanide and Resorantel are commercially available. Closantel and rafoxanide, which represent the most important drugs in the group, are used extensively for the control of Haemonchus spp. and Fasciola spp. infestations in sheep and cattle and Oestrus ovis in sheep in many parts of the world. Niclosamide is used extensively for its anticestodal activity in a wide range of animals. Antiparasitic activity of the halogenated salicylanilides has also been demonstrated against a large number of other internal parasites, in particular haematophagous helminths, and external parasites including ticks and mites, in a variety of animal species. Several cases of toxicity and mortality have been reported for closantel and rafoxanide in sheep and goats. Their unique pharmacokinetic behaviour appears to play an important role in the efficacy and safety of these compounds. The chemical and physical characteristics, mode of action, pharmacokinetics, antiparasitic activity and toxicity of the halogenated salicylanilides in animals are reviewed.
The anthelmintic efficacy of Resorantel against Houttuynia struthionis in ostriches
J S Afr Vet Assoc 1988 Dec;59(4):207-8.PMID:3210222doi
Resorantel at a dosage rate of 130 mg kg-1 live body mass was found to be highly effective against Houttuynia struthionis in ostriches when dosed alone or in combination with fenbendazole or levamisole.
The metabolism of the anthelmintics clioxanide and Resorantel and related compounds in vitro by Moniezia expansa, Ascaris suum and mouse- and sheep-liver enzymes
Xenobiotica 1979 Apr;9(4):263-8.PMID:483862DOI:10.3109/00498257909038729.
1. Clioxanide and related compounds were deacetylated by the cestode Moniezia expansa, the nematode Ascaris suum, by enzymes prepared from these species and by mouse- and sheep-liver homogenates. Deacetylase activity was found in the cytosol of cestode proglottids throughout the strobila, and in the cytosol of nematode intestinal cells and reproductive tract. 2. The O-deacetylases from both helminths showed similar pH optima of about 7.0. Activity was enhanced by Ca2+ and low molecular weight thiols. Cu2+, Cd2+, Hg2+, Zn2+, and La2+ inhibited the deacetylation of clioxanide. 3. Resorantel and clioxanide were not hydrolysed at the amide bond by helminth or mammalian enzymes. 4. Resorantel was hydroxylated by mammalian microsomal enzymes, but helminths did not modify the molecule.
The anthelmintic efficacy of Resorantel against cestodes in sheep
J S Afr Vet Assoc 1988 Dec;59(4):204-5.PMID:3210220doi
The anthelmintic efficacy of Resorantel against Thysaniezia giardi and Avitellina spp. was tested in sheep at a dosage rate of 65 mg kg-1 live mass. The reduction obtained was 100% in at least 80% of the treated flock.
Chemotherapy of paramphistomosis in sheep
Aust Vet J 1988 May;65(5):148-50.PMID:3401161DOI:10.1111/j.1751-0813.1988.tb14443.x.
Controlled trials were used to assess the efficacy of various anthelmintics against immature and adult paramphistomes in 75 experimentally or naturally infected sheep. Albendazole (20 mg/kg), praziquantel (10 mg/kg), nitroxynil (10 mg/kg) triclabendazole (10 and 100 mg/kg), profenophos (25 mg/kg) and netobimin (15 mg/kg) had little or no activity against adult or immature fluke. Niclosamide at 100 mg/kg had high efficacy (99%) against intestinal fluke but none against adult fluke. A 2- tertiary-butyl benzthiazole compound (CGA 72630) at 25 mg/kg and Resorantel at 65 mg/kg had very high efficacy against both adult and immature fluke in the rumen and small intestine respectively. The efficacy of other anthelmintics which have been used against paramphistomes in sheep is reviewed.