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Resveratroloside Sale

(Synonyms: 白藜芦醇-4'-O-葡萄糖苷,trans-Resveratrol 4'-O-β-D-glucopyranoside) 目录号 : GC61242

Resveratroloside是一种α-glucosidase的竞争新抑制剂,能调节血糖水平。Resveratroloside具有心脏保护作用。

Resveratroloside Chemical Structure

Cas No.:38963-95-0

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1mg
¥3,150.00
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5mg
¥8,820.00
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10mg
¥14,850.00
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产品描述

Resveratroloside is a competitive inhibitior of α-glucosidase with an IC50 of 22.9 μM. Resveratroloside has the ability to regulate PBG (postprandial blood glucose) levels. Resveratroloside exhibits cardioprotective effect[1][2].

[1]. Zhao X, et al. Resveratroloside Alleviates Postprandial Hyperglycemia in Diabetic Mice by Competitively Inhibiting α-Glucosidase. J Agric Food Chem. 2019 Mar 13;67(10):2886-2893. [2]. Naumenko SE, et al. Cardioprotective effect of resveratrol and resveratroloside. Cardiovasc Hematol Agents Med Chem. 2013 Sep;11(3):207-10.

Chemical Properties

Cas No. 38963-95-0 SDF
别名 白藜芦醇-4'-O-葡萄糖苷,trans-Resveratrol 4'-O-β-D-glucopyranoside
Canonical SMILES OC1=CC(O)=CC(/C=C/C(C=C2)=CC=C2O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO)=C1
分子式 C20H22O8 分子量 390.38
溶解度 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 2.5616 mL 12.808 mL 25.6161 mL
5 mM 0.5123 mL 2.5616 mL 5.1232 mL
10 mM 0.2562 mL 1.2808 mL 2.5616 mL
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Research Update

Resveratroloside Alleviates Postprandial Hyperglycemia in Diabetic Mice by Competitively Inhibiting α-Glucosidase

J Agric Food Chem 2019 Mar 13;67(10):2886-2893.PMID:30785285DOI:10.1021/acs.jafc.9b00455.

The regulation of postprandial blood glucose (PBG) levels is an effective therapeutic method to treat diabetes and prevent diabetes-related complications. Resveratroloside is a monoglucosylated form of stilbene that is present in red wine, grapes, and several traditional medicinal plants. In our study, the effect of Resveratroloside on reducing PBG was studied in vitro and in vivo. In comparison to the starch treatment alone, the oral administration of resveratroloside-starch complexes significantly inhibited the PBG increase in a dose-dependent pattern in normal and diabetic mice. The PBG level treated with resveratrol (30 mg/kg) was not lower than that of Resveratroloside. Further analyses demonstrated that Resveratroloside strongly and effectively inhibited α-glucosidase, with an 50% inhibitory concentration value of 22.9 ± 0.17 μM, and its inhibition was significantly stronger than those of acarbose and resveratrol (264 ± 3.27 and 108 ± 2.13 μM). Moreover, a competitive inhibition mechanism of Resveratroloside on α-glucosidase was determined by enzyme kinetic assays and molecular docking experiments. The molecular docking of Resveratroloside with α-glucosidase demostrated the competitive inhibitory effect of Resveratroloside, which occupies the catalytic site and forms strong hydrogen bonds with the residues of α-glucosidase. Resveratrol was also determined to be a competitive inhibition mechanism on α-glucosidase by enzyme kinetic assays and molecular docking experiments. This study suggested that Resveratroloside had the ability to regulate PBG levels and can be considered a potential agent for the treatment of diabetes mellitus.

Cardioprotective effect of resveratrol and Resveratroloside

Cardiovasc Hematol Agents Med Chem 2013 Sep;11(3):207-10.PMID:23547903DOI:10.2174/187152571103140120103302.

Cardioprotective effect of resveratrol and Resveratroloside was determined in ischemia-reperfusion experiments on rats. It was found that single intraperitoneal administration of any compound (10 mg/kg) followed by 30-min ischemia and 120-min reperfusion resulted in statistically significant decrease of myocardial infarct area (55.0±4.0% for control group; 40.7±4.4% for the group 1 received resveratrol; 41.6±4.8% for the group 2 received Resveratroloside). The cardioprotective effect of Resveratroloside was detected for the first time.

Glycyrrhetinic acid and E.Resveratroloside act as potential plant derived compounds against dopamine receptor D3 for Parkinson's disease: a pharmacoinformatics study

Drug Des Devel Ther 2014 Dec 18;9:187-98.PMID:25565772DOI:10.2147/DDDT.S72794.

Parkinson's disease (PD) is caused by loss in nigrostriatal dopaminergic neurons and is ranked as the second most common neurodegenerative disorder. Dopamine receptor D3 is considered as a potential target in drug development against PD because of its lesser side effects and higher degree of neuro-protection. One of the prominent therapies currently available for PD is the use of dopamine agonists which mimic the natural action of dopamine in the brain and stimulate dopamine receptors directly. Unfortunately, use of these pharmacological therapies such as bromocriptine, apomorphine, and ropinirole provides only temporary relief of the disease symptoms and is frequently linked with insomnia, anxiety, depression, and agitation. Thus, there is a need for an alternative treatment that not only hinders neurodegeneration, but also has few or no side effects. Since the past decade, much attention has been given to exploitation of phytochemicals and their use in alternative medicine research. This is because plants are a cheap, indispensable, and never ending resource of active compounds that are beneficial against various diseases. In the current study, 40 active phytochemicals against PD were selected through literature survey. These ligands were docked with dopamine receptor D3 using AutoDock and AutoDockVina. Binding energies were compared to docking results of drugs approved by the US Food and Drug Administration against PD. The compounds were further analyzed for their absorption, distribution, metabolism, and excretion-toxicity profile. From the study it is concluded that glycyrrhetinic acid and E.Resveratroloside are potent compounds having high binding energies which should be considered as potential lead compounds for drug development against PD.

From bench to counter: Discovery and validation of a peony extract as tyrosinase inhibiting cosmeceutical

Eur J Med Chem 2019 Dec 15;184:111738.PMID:31655335DOI:10.1016/j.ejmech.2019.111738.

The anti-melanogenic principle of peony (Paeonia officinalis subsp. officinalis) seeds was elucidated via activity-guided isolation. Resveratroloside (trans-resveratrol-4'-O-beta-d-glucopyranoside) was found to be the main metabolite of P. officinalis subsp. officinalis seeds and its tyrosinase inhibiting activity was confirmed via an enzymatic assay. Furthermore, the in vitro activity and the therapeutic window were studied employing the murine melanoma cell line B16F10. The results from the conducted stability assay and the high content of Resveratroloside in the seeds (i.e. 10.4% dw) motivated us to push the extract forward to an in vivo tolerance assay. A clinical study with forty Caucasian participants proofed a good skin-tolerance with high moisture effect and reduction of pores.

Analysis and functionality of major polyphenolic components of Polygonum cuspidatum (itadori)

J Nutr Sci Vitaminol (Tokyo) 2012;58(4):278-86.PMID:23132312DOI:10.3177/jnsv.58.278.

Polygonum cuspidatum has been broadly utilized as a herbal medicine in Asia, but the outline of the polyphenol compounds in the plant has not been characterized well. In the present study, the major polyphenolic components were isolated from the roots of P. cuspidatum, and identified as resveratrol and its glucosides, Resveratroloside and polydatin. On the other hand, chlorogenic acid was found to be one of the polyphenolic components in the leaves and stems of the plant. Next, we elucidated that resveratrol derivatives and chlorogenic acid exhibit α-glucosidase inhibitory activities, and Resveratroloside exhibits the same inhibitory activity as quercetin does. Furthermore, DPPH radical scavenging activities of antioxidants including resveratrol derivatives and chlorogenic acid derivatives were examined by initial rate analyses of their reactions. Subsequently, it was revealed that resveratrol derivatives have slow-acting effects on the radical scavenging activity and that chlorogenic acid derivatives exhibit very fast-acting effects.