Reynoutrin

Quercetin 3-O-β-D-xylopyranoside is a flavonoid glycoside that has been found in N. candida and has diverse biological activities.^1,2,3 It reduces malondialdehyde (MDA) levels in isolated rat brain when used at a concentration of 10 ?g/ml.¹ Quercetin 3-O-β-D-xylopyranoside (10, 50, and 100 ?g/ml) reduces LPS- and cerulein-induced increases in reactive oxygen species (ROS) production and levels of GRP78, a marker of endoplasmic reticulum stress, in an AR42J rat pancreatic acinar cell model of pancreatitis.² In vivo, quercetin 3-O-β-D-xylopyranoside (12.5, 25, and 50 mg/kg) decreases serum TNF-α and IL-6 levels, myocardial MDA levels, and myocardial fibrosis, as well as improves cardiac function, in a rat model of ischemic heart failure.³

1.Liu, R.-N., Wang, W., Ding, Y., et al.A new flavonol glycoside and activity of compounds from the flower of Nymphaea candidaJ. Asian Nat. Prod. Res.9(3-5)333-338(2007) 2.Seo, J.Y., Pandey, R.P., Lee, J., et al.Quercetin 3-O-xyloside ameliorates acute pancreatitis in vitro via the reduction of ER stress and enhancement of apoptosisPhytomedicine5540-49(2019) 3.Yang, W., Tu, H., Tang, K., et al.Reynoutrin improves ischemic heart failure in rats via targeting S100A1Front. Pharmacol.12703962(2021)