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Rhein Sale

(Synonyms: 大黄酸; Rheic Acid; Rhubarb yellow; Monorhein) 目录号 : GN10475

An anthraquinone derivative

Rhein Chemical Structure

Cas No.:478-43-3

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20mg
¥515.00
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产品描述

Rhein is a lipophilic anthraquinone extensively found in medicinal herbs, and has many pharmacological effects, including epatoprotective, nephroprotective, anti-inflammatory, antioxidant, anticancer, and antimicrobial activities. IC50 value:Target:In vitro: Rhein (0.1 and 1 mg/mL) evidently suppressed cell proliferation and mitogen-activated protein (MAP) kinase activation in human colon adenocarcinoma cells (Caco-2) but significantly lessened H2O2-induced DNA damage and the elevated MDA and ROS levels induced by H2O2/Fe2+ at the concentrations of 0.1–10 mg/mL [1].In vivo: Oral administration of rhein (150 mg/kg/d) evidently ameliorated renal interstitial fibrotic lesions and attenuated the expression of α-SMA and deposition of fibronectin (FN) in mice with renal interstitial fibrosis induced by unilateral ureteral obstruction. Rhein also suppressed TGF-β1 and its type I receptor expression in obstructed kidneys [1]. The biochemical parameters results of IgAN model rats showed that rhein-prevented and rhein-treated both improved the biochemical parameters and relieved renal pathological injury. The expressions of renal tissue TLR4, TGF-β1, but not TLR9 were significantly elevated in IgAN model rats (P < 0.05). Rhein-prevented and rhein-treated both inhibited TLR4 and TGF-β1 expressions [2].

References:
[1]. Xiaowen Chen, et al. Toll-like receptor 4 is involved in a protective effect of rhein on immunoglobulin A nephropathy. Indian J Pharmacol. 2015 Jan-Feb; 47(1): 27–33.
[2]. Hou ML, et al. The Drug-Drug Effects of Rhein on the Pharmacokinetics and Pharmacodynamics of Clozapine in Rat Brain Extracellular Fluid by In Vivo Microdialysis. J Pharmacol Exp Ther. 2015 Oct;355(1):125-34.
[3]. Yan-Xi Zhou, et al. Rhein: A Review of Pharmacological Activities. Evid Based Complement Alternat Med. 2015; 2015: 578107.

Chemical Properties

Cas No. 478-43-3 SDF
别名 大黄酸; Rheic Acid; Rhubarb yellow; Monorhein
化学名 4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid
Canonical SMILES C1=CC2=C(C(=C1)O)C(=O)C3=C(C=C(C=C3C2=O)C(=O)O)O
分子式 C15H8O6 分子量 284.22
溶解度 ≥ 7.1mg/mL in DMSO 储存条件 Store at RT
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1 mg 5 mg 10 mg
1 mM 3.5184 mL 17.592 mL 35.184 mL
5 mM 0.7037 mL 3.5184 mL 7.0368 mL
10 mM 0.3518 mL 1.7592 mL 3.5184 mL
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