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Risedronate Sale

(Synonyms: 利塞膦酸; Risedronate) 目录号 : GC10399

An aminobisphosphonate and antimalarial agent

Risedronate Chemical Structure

Cas No.:105462-24-6

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Risedronic acid (Risedronate ) is a pyridinyl biphosphonate which inhibits osteoclast-mediated bone resorption.Target: OthersRisedronate, which was promoted in Croatia a few months ago, is the latest (III) generation of bisphosphonates, the most efficient anti-resorption drugs that inhibit osteoclast-mediated bone resorption and change the bone metabolism. Risedronate is hence the first line of bisphosphonates for the reduction of vertebral and non-vertebral fracture risks in postmenopausal women with osteoporosis or those with a high risk of osteoporosis. It also efficiently prevents bone loss or improves bone density in men and women on a long-term corticosteroid therapy .The administration of 20 and 25 mg/kg risedronate for 4 days led to decreases of parasitemia of 68.9% and 83.6%, respectively. On the seventh day of treatment the inhibitions were 63% and 88.9% with 20 and 25 mg/kg, respectively. After recovering the parasitemia, a dose-response curve was obtained for estimating the ID50 (dose causing 50% inhibition), equivalent to 17 ± 1.8 mg/kg after 7 days of treatment. Four days after the interruption of treatment (11 days postinfection), the parasitemias of the groups treated with 10, 15, 20, and 25 mg/kg/day were 15.3%, 15.9%, 15.2%, and 5.7%, respectively. Conversely, the group that received PBS presented parasitemia of 25.6%. Among the groups treated with risedronate, only the animals that received 25 mg/kg had a significant inhibition of 77.8% (see Table S1 in the supplemental material), demonstrating that even after treatment discontinuation, the parasitemia of the animals remained low in relation to that of the controls .

References:
[1]. Giljevic Z, et al. Treatment of osteoporosis by risedronate-- speed, efficacy and safety. Reumatizam. 2006;53(2):66-71.
[2]. Jordao FM, et al. In vitro and in vivo antiplasmodial activities of risedronate and its interference with protein prenylation in Plasmodium falciparum. Antimicrob Agents Chemother. 2011 May;55(5):2026-31.

Chemical Properties

Cas No. 105462-24-6 SDF
别名 利塞膦酸; Risedronate
化学名 (1-hydroxy-1-phosphono-2-pyridin-3-ylethyl)phosphonic acid
Canonical SMILES C1=CC(=CN=C1)CC(O)(P(=O)(O)O)P(=O)(O)O
分子式 C7H11NO7P2 分子量 283.11
溶解度 <2.83mg/mL in DMSO, Limited solubility in EtOH 储存条件 Store at -20°C
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.5322 mL 17.661 mL 35.322 mL
5 mM 0.7064 mL 3.5322 mL 7.0644 mL
10 mM 0.3532 mL 1.7661 mL 3.5322 mL
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