RLN3 Human
目录号 : GP24397Relaxin-3 Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 95.0% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. | Shipping Condition | Shipped at Room temp. |
| Synonyms | Relaxin 3; Prorelaxin H3; RXN3; Insl7; ZINS4; H3; Relaxin 3 (H3); Relaxin-3; RLN3. | ||
| Amino Acid Sequence | A chain: DVLAGLSSSC CKWGCSKSEI SSLC.B chain: RAAPYGVRLCG REFIRAVIFT CGGSRW. | ||
| Solubility | It is recommended to reconstitute the lyophilized RLN3 in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. | ||
| Stability | Lyophilized RLN3 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C . Upon reconstitution Relaxin-3 should be stored at 4°C between 2-7 days and for future use below -18°C .For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. | ||
| Biological Activity | The ED50, as measured by cAMP accumulation in human THP-1 cells, is less than 17.5ng/ml. | ||
| Formulation | Lyophilized from a 0.2µm filtered solution in Acetonitrile and TFA. | ||
Relaxin-3 (RLN3) belongs to the relaxin family. Relaxinsare endocrine and autocrine/paracrine hormones. Relaxin, which is produced by the ovary, targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. Unlike human Relaxins 1 and 2, Relaxin 3 does not seem to have a role in reproduction; however it is involved in stress response in the brain stem. RLN3 is the only known ligand for the G-protein-coupled receptor GPCR135, titled RXFP3. In addition, RLN3 binds the LGR7 (RXFP1) receptor, however with lower affinity than Relaxin-2. Even though binding of RLN3 to LGR7 increases intracellular cAMP, binding to GPCR135 suppresses cAMP accumulation, indicating coupling to Gi, Go, or Gz by this receptor.
The ED50, as measured by cAMP accumulation in human THP-1 cells, is less than 17.5ng/ml.
Lyophilized RLN3 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C . Upon reconstitution Relaxin-3 should be stored at 4°C between 2-7 days and for future use below -18°C .For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.