Rp-Adenosine-5'-O-(1-thiotriphosphate) (sodium salt)
(Synonyms: Rp-ATP-α-S) 目录号 : GC90895一种ATP-α-S的同分异构体和P2Y1受体激动剂
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Rp-Adenosine-5'-O-(1-thiotriphosphate) (Rp-ATP-α-S) is an isomer of the sulfur-containing nucleotide derivative ATP-α-S and an agonist of the purinergic P2Y1 receptor.1 It increases calcium mobilization in HEK293 cells expressing the human P2Y1 receptor (EC50 = 75 nM). Rp-ATP-α-S binds to washed isolated human platelets (Ki = 156 nM), inhibits ADP-induced aggregation of isolated human platelet-rich plasma (PRP; pA2 = 4.74), and inhibits cAMP production induced by prostaglandin E1 in isolated human PRP (pA2 = 5.26).2,3 It also induces relaxation of carbamoylcholine-preconstricted guinea pig taenia coli strips (EC50 = 56 nM).4 Rp-ATP-α-S has been used in the synthesis of cyclic dinucleotides that are recognized by bacterial riboswitches.5
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.6361 mL | 8.1806 mL | 16.3613 mL |
| 5 mM | 0.3272 mL | 1.6361 mL | 3.2723 mL |
| 10 mM | 0.1636 mL | 0.8181 mL | 1.6361 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。