RS Repeat Peptide (trifluoroacetate salt)
目录号 : GC91854RS repeat peptide is a serine/arginine-rich peptide substrate for CDC-like kinase 1 (Clk1).
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
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- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
RS repeat peptide is a serine/arginine-rich peptide substrate for CDC-like kinase 1 (Clk1).[1],[2] It has been used to identify inhibitors of Clk1 with anticancer activity.
References:
[1].Araki, S., Dairiki, R., Nakayama, Y., et al.Inhibitors of CLK protein kinases suppress cell growth and induce apoptosis by modulating pre-mRNA splicingPLoS One10(1)e0116929(2015).
[2].Schmitt, C., Kail, D., Mariano, M., et al.Design and synthesis of a library of lead-like 2,4-bisheterocyclic substituted thiophenes as selective Dyrk/Clk inhibitorsPLoS One9(3)e87851(2014).
制备储备液 | |||
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1 mg | 5 mg | 10 mg |
1 mM | 0.517 mL | 2.5852 mL | 5.1704 mL |
5 mM | 0.1034 mL | 0.517 mL | 1.0341 mL |
10 mM | 0.0517 mL | 0.2585 mL | 0.517 mL |
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量) | ||||||||||
给药剂量 | mg/kg | 动物平均体重 | g | 每只动物给药体积 | ul | 动物数量 | 只 | |||
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方) | ||||||||||
% DMSO % % Tween 80 % saline | ||||||||||
计算重置 |
计算结果:
工作液浓度: mg/ml;
DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,
体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL saline,混匀澄清。
1. 首先保证母液是澄清的;
2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。