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(S)-(+)-1,2-Propanediol Sale

(Synonyms: (S)-1,2-丙二醇) 目录号 : GC39833

(S)-(+)-1,2-Propanediol 是一种内源性代谢产物。

(S)-(+)-1,2-Propanediol Chemical Structure

Cas No.:4254-15-3

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10mM (in 1mL DMSO)
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500mg
¥350.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

(S)-(+)-1,2-Propanediol is an endogenous metabolite.

Chemical Properties

Cas No. 4254-15-3 SDF
别名 (S)-1,2-丙二醇
Canonical SMILES C[C@H](O)CO
分子式 C3H8O2 分子量 76.09
溶解度 DMSO : 100 mg/mL (1314.23 mM; Need ultrasonic) 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 13.1423 mL 65.7117 mL 131.4233 mL
5 mM 2.6285 mL 13.1423 mL 26.2847 mL
10 mM 1.3142 mL 6.5712 mL 13.1423 mL
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Research Update

Propylene Glycol

Dermatitis 2018 Jan-Feb;29(1):3-5.PMID:29059092DOI:10.1097/DER.0000000000000315.

Propylene glycol (PG), an emollient and emulsifier found in cosmetics, medications, and food, has been granted the dubious honor of being named the American Contact Dermatitis Society'S Allergen of the Year for 2018. Allergic and irritant contact dermatitis and systemic cutaneous reactions to PG, which has become an increasingly common ingredient, have been documented. Propylene glycol is as contentious as it is ubiquitous because it acts as both a weak sensitizer and an irritant, confounding the results of positive patch tests. This report serves to increase awareness about PG sensitization and appropriate testing and evaluation of PG patch tests.

Production of (S)-1,2-propanediol from l-rhamnose using the moderately thermophilic Clostridium strain AK1

Anaerobe 2018 Dec;54:26-30.PMID:30009943DOI:10.1016/j.anaerobe.2018.07.003.

Clostridium strain AK1 was investigated for its capacity of producing 1,2-propanediol from l-rhamnose but not l-fucose. The maximum yields of 1,2-propanediol from rhamnose was 0.81 mol 1,2-PD/mol l-rhamnose. The influence of different initial substrate concentrations as well as the effect of temperature and pH on 1,2-PD production was investigated.

Regulation of fucose and 1,2-propanediol utilization by Salmonella enterica serovar Typhimurium

Front Microbiol 2015 Oct 12;6:1116.PMID:26528264DOI:10.3389/fmicb.2015.01116.

After ingestion, Salmonella enterica serovar Typhimurium (S. Typhimurium) encounters a densely populated, competitive environment in the gastrointestinal tract. To escape nutrient limitation caused by the intestinal microbiota, this pathogen has acquired specific metabolic traits to use compounds that are not metabolized by the commensal bacteria. For example, the utilization of 1,2-propanediol (1,2-PD), a product of the fermentation of L-fucose, which is present in foods of herbal origin and is also a terminal sugar of gut mucins. Under anaerobic conditions and in the presence of tetrathionate, 1,2-PD can serve as an energy source for S. Typhimurium. Comprehensive database analysis revealed that the 1,2-PD and fucose utilization operons are present in all S. enterica serovars sequenced thus far. The operon, consisting of 21 genes, is expressed as a single polycistronic mRNA. As demonstrated here, 1,2-PD was formed and further used when S. Typhimurium strain 14028 was grown with L-fucose, and the gene fucA encoding L-fuculose-1-phosphate aldolase was required for this growth. Using promoter fusions, we monitored the expression of the propanediol utilization operon that was induced at very low concentrations of 1,2-PD and was inhibited by the presence of D-glucose.

Respiration of Microbiota-Derived 1,2-propanediol Drives Salmonella Expansion during Colitis

PLoS Pathog 2017 Jan 5;13(1):e1006129.PMID:28056091DOI:10.1371/journal.ppat.1006129.

Intestinal inflammation caused by Salmonella enterica serovar Typhimurium increases the availability of electron acceptors that fuel a respiratory growth of the pathogen in the intestinal lumen. Here we show that one of the carbon sources driving this respiratory expansion in the mouse model is 1,2-propanediol, a microbial fermentation product. 1,2-propanediol utilization required intestinal inflammation induced by virulence factors of the pathogen. S. Typhimurium used both aerobic and anaerobic respiration to consume 1,2-propanediol and expand in the murine large intestine. 1,2-propanediol-utilization did not confer a benefit in germ-free mice, but the pdu genes conferred a fitness advantage upon S. Typhimurium in mice mono-associated with Bacteroides fragilis or Bacteroides thetaiotaomicron. Collectively, our data suggest that intestinal inflammation enables S. Typhimurium to sidestep nutritional competition by respiring a microbiota-derived fermentation product.

Assessment of 1,2-propanediol (PrOH) genotoxicity on mouse oocytes by comet assay

Fertil Steril 2011 Oct;96(4):1002-7.PMID:21890131DOI:10.1016/j.fertnstert.2011.07.1106.

Objective: To assess the genotoxicity of 1,2-propanediol (PrOH) on mouse oocytes by comet assay. Design: In vitro assay using murine model. Setting: Biogenotoxicology research laboratory. Animal(S): CD1 female mice. Intervention(S): Three 40-oocyte groups were exposed to different PrOH concentrations (5%, 7.5%, and 15%). Each concentration was tested during both long and short exposures (1-2 hours and 1-5 minutes) in comparison with control groups. DNA damage was evaluated by a single-cell gel electrophoresis assay, also called "comet assay," and analyzed with Komet software. Main outcome measure(S): DNA damage was quantified as Olive tail moment (OTM). Interpretation was done on OTM with the use of χ(2). Result(S): High PrOH concentrations (7.5% and 15%) induced significant DNA damage on mouse oocytes. The OTM χ(2) values were 4.16 ± 0.40 and 6.80 ± 0.4 with 7.5% PrOH at 1 and 2 hours, respectively, 24.35 ± 1.60 with 15% at 1 hour, and for 2h at 15% the DNA damage was too drastic to calculate OTM χ(2). After 1 and 5 minutes, the OTM χ(2) values were, respectively, 5.19 ± 0.26 and 6.06 ± 0.42 with 7.5%, and 7.53 ± 0.33 and 16.81 ± 0.67 with 15%. Conclusion(S): High concentrations of PrOH (7.5% and 15%) induced significant DNA damage on mouse oocytes, whatever the exposure duration. These results should be interpreted with caution, because additional data are needed to evaluate PrOH genotoxicity and DNA oocyte reparation after exposure to high PrOH concentrations.