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(S)-3'-amino Blebbistatin Sale

(Synonyms: (-)-3'-amino Blebbistatin, m-amino Blebbistatin, meta-amino Blebbistatin) 目录号 : GC41557

A more stable form of (–)-blebbistatin

(S)-3'-amino Blebbistatin Chemical Structure

Cas No.:2097141-18-7

规格 价格 库存 购买数量
500μg
¥1,696.00
现货
1mg
¥3,221.00
现货
5mg
¥15,264.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

(S)-3'-amino Blebbistatin is a more stable and less phototoxic form of (-)-blebbistatin , which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. (-)-Blebbistatin rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50s = 0.5-5 µM), while poorly inhibiting smooth muscle myosin (IC50 = 80 µM). Through these effects, it blocks apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells. However, prolonged exposure to blue light (450-490 nm) results in degradation of blebbistatin to an inactive product via cytotoxic intermediates, which may be problematic for its use in fluorescent live cell imaging applications. The addition of a 3'-amino group decreases the inherent fluorescence while retaining the activity of (-)-blebbistatin. (S)-3'-amino Blebbistatin has the same stereochemistry as the active (-)-blebbistatin enantiomer.

Chemical Properties

Cas No. 2097141-18-7 SDF
别名 (-)-3'-amino Blebbistatin, m-amino Blebbistatin, meta-amino Blebbistatin
Canonical SMILES O=C1[C@@]2(O)C(N(C3=CC=CC(N)=C3)CC2)=NC4=C1C=C(C)C=C4
分子式 C18H17N3O2 分子量 307.3
溶解度 DMF: 20 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 12.5 mg/ml 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.2541 mL 16.2707 mL 32.5415 mL
5 mM 0.6508 mL 3.2541 mL 6.5083 mL
10 mM 0.3254 mL 1.6271 mL 3.2541 mL
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