(S)-Indoximod
(Synonyms: 相思子碱,1-Methyl-L-tryptophan; (S)-NLG-8189) 目录号 : GC60417
An IDO inhibitor
Cas No.:21339-55-9
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
1-methyl-L-Tryptophan is an inhibitor of indoleamine 2,3-dioxygenase (IDO; Ki = 19 ?M).1 It inhibits kynurenine production from primary human monocyte-derived IDO-positive dendritic cells and increases T cell proliferation in an allogeneic mixed lymphocyte reaction (allo-MLR) when used at a concentration of 100 ?M. 1-methyl-L-Tryptophan reverses depressive-like behavior in mice in a Bacillus Calmette-Guerin inflammation-induced model of depression.2 Unlike 1-methyl-D-tryptophan, 1-methyl-L-tryptophan does not have an additive effect on survival induced by cyclophosphamide in an orthotopic murine mammary carcinoma model of 4T1 tumors when administered at a dose of 400 mg/kg twice per day.1
1.Hou, D.-Y., Muller, A.J., Sharma, M.D., et al.Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responsesCancer Res.67(2)792-801(2007) 2.Rana, P., Sharma, A.K., Jain, S., et al.Comparison of fluoxetine and 1-methyl-L-tryptophan in treatment of depression-like illness in Bacillus Calmette-Guerin-induced inflammatory model of depression in miceJ. Basic Clin. Physiol. Pharmacol.27(6)569-576(2016)
| Cas No. | 21339-55-9 | SDF | |
| 别名 | 相思子碱,1-Methyl-L-tryptophan; (S)-NLG-8189 | ||
| Canonical SMILES | N[C@@H](CC1=CN(C)C2=CC=CC=C12)C(O)=O | ||
| 分子式 | C12H14N2O2 | 分子量 | 218.25 |
| 溶解度 | DMSO: 5 mg/mL (22.91 mM; ultrasonic and adjust pH to 5 with HCl); 2.28 mg/mL in Water(ultrasonic and warming and heat) | 储存条件 | 4°C, protect from light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
||
| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 4.5819 mL | 22.9095 mL | 45.819 mL |
| 5 mM | 0.9164 mL | 4.5819 mL | 9.1638 mL |
| 10 mM | 0.4582 mL | 2.291 mL | 4.5819 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet