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S119-8 Sale

目录号 : GC32222

S119-8是A型和B型流感病毒的广谱抑制剂。

S119-8 Chemical Structure

Cas No.:443639-96-1

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥792.00
现货
5mg
¥720.00
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10mg
¥1,260.00
现货
25mg
¥2,250.00
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50mg
¥3,375.00
现货
100mg
¥4,950.00
现货

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Sample solution is provided at 25 µL, 10mM.

Description

S119-8 is a broad spectrum inhibitor of influenza A and B viruses.

S119-8 is an analog of S119. S119-8 has acquired enhanced broad-spectrum activity with improved calculated physical properties, while maintaining significant potency (IC50=1.43 μM) at non-toxic (CC50=66.10 μM) concentrations, albeit somewhat higher (7-fold) than that of the parent S119 against influenza A/WSN/33 H1N1 (WSN) virus. S119-8 also shows activity against multiple influenza B viruses and an oseltamivir-resistant influenza A virus, but does not inhibit a non-influenza virus, vesicular stomatitis nirus (VSV). S119-8 has increased breadth of inhibition against influenza A and B viruses accompanied by only a small loss in potency. S119-8 inhibits influenza viruses A/Puerto Rico/8/1934 (H1N1) (PR8) with an IC50 of 6.05 μM. S119-8 inhibits influenza A/Vietnam/1203/2004 (H5N1) with an IC50 of 8.42 μM[1].

[1]. White KM, et al. Broad Spectrum Inhibitor of Influenza A and B Viruses Targeting the Viral Nucleoprotein. ACS Infect Dis. 2018 Feb 9;4(2):146-157.

化学性质

Cas No. 443639-96-1 SDF
Canonical SMILES O=C(NC1=CC=C(NC2=CC=CC=C2)C=C1)C3=CC=C(C(C)(C)C)C=C3
分子式 C23H24N2O 分子量 344.45
溶解度 DMSO : ≥ 150 mg/mL (435.48 mM) 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

制备储备液
1 mg 5 mg 10 mg
1 mM 2.9032 mL 14.5159 mL 29.0318 mL
5 mM 0.5806 mL 2.9032 mL 5.8064 mL
10 mM 0.2903 mL 1.4516 mL 2.9032 mL
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