S32826 disodium
目录号 : GC63997
Inhibitor of autotaxin (lysophospholipase D)
Cas No.:1103672-43-0
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Autotaxin is a lysophospholipase D, cleaving lysophosphatidylcholine to produce choline and lysophosphatidic acid (LPA). S32826 is a potent and selective inhibitor of autotaxin, inhibiting recombinant autotaxin β with an IC50 of 8.8 nM.1 It shows similar effectiveness against the three known autotaxin isoforms (α, β, and γ). It has no effect on a variety of receptors and enzymes, with the exceptions of src (IC50 = 6 μM) and phosphatase 1B (IC50 = 15 μM).1 S32826 inhibits LPA release from adipocytes (IC50 = 90 nM) and reduces plasma autotaxin activity by 57% when used at 5 μM.1
1.Ferry, G., Moulharat, N., Pradère, J.P., et al.S32826, a nanomolar inhibitor of autotaxin: Discovery, synthesis and applications as a pharmacological toolJ. Pharmacol. Exp. Ther.327809-819(2008)
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.2653 mL | 11.3263 mL | 22.6526 mL |
| 5 mM | 0.4531 mL | 2.2653 mL | 4.5305 mL |
| 10 mM | 0.2265 mL | 1.1326 mL | 2.2653 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。