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Safinamide Mesylate Sale

(Synonyms: 沙芬酰胺甲磺酸盐,FCE-28073, PNU 151774E, methanesulfonate) 目录号 : GC14673

An inhibitor of MAO-B

Safinamide Mesylate Chemical Structure

Cas No.:202825-46-5

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥1,292.00
现货
10mg
¥777.00
现货
50mg
¥2,499.00
现货
500mg
¥5,534.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Safinamide mesylate is the methanesulfonic acid form of its active component safinamide, a selective and reversible monoamine oxidase B (MAO-B) inhibitor with the value of 50% inhibition concentration IC50 of 98 nM. Having been used for the treatment of Parkinson’s disease (PD), safinamide potently modulates dopamine (DA), a substrate of MAO-B, suppressing DA uptake and reversibly binds to MAO-B blocking the function of MAO-B, which lead to the relief of PD symptoms. Besides MAO-B inhibition, safinamide exhibits novel anticonvulsant activities, including sodium channel blockade, calcium channel blockade and glutamate release inhibition, with values of IC50 of 8.2 μM, 31.5 μM and >56.4 μM respectively.

Reference

[1].Fariello RG, McArthur RA, Bonsignori A, Cervini MA, Maj R, Marrari P, Pevarello P, Wolf HH, Woodhead JW, White HS, Varasi M, Salvati P, Post C. Preclinical evaluation of PNU-151774E as a novel anticonvulsant. J Pharmacol Exp Ther. 1998; 285(2): 397-403
[2].Onofrj M, Bonanni L, Thomas A. An expert opinion on safinamide in Parkinson's disease. Expert Opin Investig Drugs. 2008;17(7):1115-1125
[3].Naveed M Malek, Donald G Grosset. Investigational agents in the treatment of Parkinson's disease: focus on safinamide. Journal of Experimental Pharmacology 2012: 4 85-90

Chemical Properties

Cas No. 202825-46-5 SDF
别名 沙芬酰胺甲磺酸盐,FCE-28073, PNU 151774E, methanesulfonate
化学名 (2S)-2-[[4-[(3-fluorophenyl)methoxy]phenyl]methylamino]propanamide;methanesulfonic acid
Canonical SMILES CC(C(=O)N)NCC1=CC=C(C=C1)OCC2=CC(=CC=C2)F.CS(=O)(=O)O
分子式 C17H19FN2O2.CH4O3S 分子量 398.45
溶解度 ≥ 16.1 mg/mL in DMSO, ≥ 10.08 mg/mL in EtOH with ultrasonic and warming, ≥ 84.6 mg/mL in Water 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.5097 mL 12.5486 mL 25.0973 mL
5 mM 0.5019 mL 2.5097 mL 5.0195 mL
10 mM 0.251 mL 1.2549 mL 2.5097 mL
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