Salvianolic acid B

Salvianolic acid B is a water-soluble phenolic compound extracted from Salvia miltiorrhiza, which has many pharmacological effects, including anti-tumor, anti-inflammation and anti-oxidation. Salvianolic acid B can cross the blood-brain barrier and directly act on the central nervous system ^[1-4].

Amyloid beta protein fragment 1-40 (Aβ40) shows obvious toxic effects after incubation of PC12 cells for 30 h, and Salvianolic acid B (10nM and 100nM) can significantly reduce the toxic effects of Aβ40 ^[2]. Salvianolic acid B can inhibit the growth of JHU-022 and JHU-013 cells with IC₅₀ values of 18 and 50μM, respectively. Treatment of JHU-022 cells with different concentrations of Salvianolic acid B (12.5-125μM) for 24 h reduced the level of cycooxygenase-2 (COX-2) protein by 50-61% ^[3].

Salvianolic acid B (80mg/kg) can inhibit tumor growth in nude mouse model of JHU-013 cell xenotransplantation, and the average tumor weight of Salvianolic acid B treatment group is significantly lower than that of untreated group ^[3]. In the rat model of depression induced by chronic mild stress (CMS), Salvianolic acid B (30mg/kg) can significantly increase the sucrose preference of rats, reduce the rest time of rats in the forced swimming experiment, and improve the depression-like behavior of rats ^[4].

References:
[1]Guo P, Wang S, Liang W, et al. Salvianolic acid B reverses multidrug resistance in HCT‑8/VCR human colorectal cancer cells by increasing ROS levels[J]. Molecular Medicine Reports, 2017, 15(2): 724-730.
[2] Tang MK, Zhang JT. Salvianolic acid B inhibits fibril formation and neurotoxicity of amyloid beta-protein in vitro. Acta Pharmacol Sin. 2001 Apr;22(4):380-4.
[3] Hao Y, Xie T, Korotcov A, et al. Salvianolic acid B inhibits growth of head and neck squamous cell carcinoma in vitro and in vivovia cyclooxygenase-2 and apoptotic pathways[J]. International Journal of Cancer, 2009, 124(9): 2200-2209.
[4] Liao D, Chen Y, Guo Y, Wang C, Liu N, Gong Q, Fu Y, Fu Y, Cao L, Yao D, Jiang P. Salvianolic Acid B Improves Chronic Mild Stress-Induced Depressive Behaviors in Rats: Involvement of AMPK/SIRT1 Signaling Pathway. J Inflamm Res. 2020 May 12;13:195-206.

Salvianolic acid B是一种从丹参中提取的水溶性酚类化合物，具有多种药理作用，包括抗肿瘤、抗炎和抗氧化等。Salvianolic acid B可以穿过血脑屏障，直接作用于中枢神经系统^[1-4]。

淀粉样β蛋白片段1-40（Aβ₄₀）在孵育PC12细胞30 h后显示出明显的毒性作用，Salvianolic acid B（10nM和100nM）可显著降低Aβ₄₀的毒性作用^[2]。Salvianolic acid B可抑制JHU-022和JHU-013细胞的生长，IC₅₀值分别为18和50μM。使用不同浓度的Salvianolic acid B（12.5-125μM）处理JHU-022细胞24小时，环氧化酶2（COX-2）蛋白水平降低了50-61%^[3]。

Salvianolic acid B（80mg/kg）可抑制JHU-013细胞异种移植裸鼠模型中裸鼠肿瘤的生长，Salvianolic acid B治疗组平均肿瘤重量显著低于未治疗组^[3]。在慢性轻度应激（CMS）诱导的大鼠抑郁模型中，Salvianolic acid B（30mg/kg）可显著增加大鼠蔗糖偏好，减少大鼠在强迫游泳实验中静止时间，改善了大鼠的抑郁样行为^[4]。