Sancycline (Bonomycin)

Sancycline is a semisynthetic tetracycline antibiotic that is more active than tetracycline against 339 strains of anaerobic bacteria (average MIC₉₀s = 1 and 32 μg/ml, respectively).^1,2 Sancycline is active against tetracycline-resistant E. coli, S. aureus, and E. faecalis strains with MICs ranging from 0.06 to 1 μg/ml.³ In vivo, sancycline is active against S. aureus in mice with ED₅₀ values of 0.46 and 0.6 mg/kg for intravenous and subcutaneous administration, respectively.

1.McCormick, J.R.D., Jensen, E.R., Miller, P.A., et al.The 6-deoxytetracyclines. Further studies on the relationship between structure and antibacterial activity in the tetracycline seriesJ. Am. Chem. Soc.82(13)3381-3386(1960) 2.Wexler, H.M., Molitoris, E., and Finegold, S.M.In vitro activities of two new glycylcyclines, N,N-dimethylglycylamido derivatives of minocycline and 6-demethyl-6-deoxytetracycline, against 339 strains of anaerobic bacteriaAntimicrob. Agents Chemother.38(10)2513-2515(1994) 3.Testa, R.T., Perterson, P.J., Jacobus, N.V., et al.In vitro and in vivo antibacterial activities of the glycylcyclines, a new class of semisynthetic tetracyclinesAntimicrob. Agents Chemother.37(11)2270-2277(1993)