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SB-334867 free base Sale

(Synonyms: 1-(2-甲基苯并[D]噁唑-6-基)-3-(1,5-萘啶-4-基)脲,SB334867A free base) 目录号 : GC15034

An orexin 1 receptor antagonist

SB-334867 free base Chemical Structure

Cas No.:792173-99-0

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥693.00
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5mg
¥630.00
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10mg
¥1,080.00
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50mg
¥3,555.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

SB-334867 free base is a selective antagonist of orexin-1 receptor [1].

Orexin-A and orexin-B are two peptides isolated from rat hypothalamus. They are involved in some physiological functions such as the control of feeding, energy metabolism and regulation of the sleep-wake cycle.

SB-334867 free base could inhibit the orexin-A and orexin-B induced calcium responses in CHO-OX1 cells with pKB values of 7.27 and 7.23, respectively. SB-334867 was more selective for OX1 receptor over OX2 receptor. It caused 32.7% and 22% inhibition of orexin-A and orexin-B induced calcium responses in CHO-OX2 cells, respectively. Moreover, SB-334867 was found to reduce both orexin-A-induced and fasting-induced food intake. The acute anorectic effect of it was associated with significant reductions in all active behaviours [1, 2].

References:
[1] Smart D, Sabido-David C, Brough S J, et al.  SB-334867-A: the first selective orexin-1 receptor antagonist. British journal of pharmacology, 2001, 132(6): 1179-1182.
[2] Rodgers R J, Halford J C G, Nunes de Souza R L, et al.  SB-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-A in rats. European Journal of Neuroscience, 2001, 13(7): 1444-1452.

Chemical Properties

Cas No. 792173-99-0 SDF
别名 1-(2-甲基苯并[D]噁唑-6-基)-3-(1,5-萘啶-4-基)脲,SB334867A free base
化学名 1-(2-methyl-1,3-benzoxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea
Canonical SMILES CC1=NC2=C(O1)C=C(C=C2)NC(=O)NC3=C4C(=NC=C3)C=CC=N4
分子式 C17H13N5O2 分子量 319.32
溶解度 ≥ 14.55mg/mL in DMSO 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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1 mg 5 mg 10 mg
1 mM 3.1317 mL 15.6583 mL 31.3165 mL
5 mM 0.6263 mL 3.1317 mL 6.2633 mL
10 mM 0.3132 mL 1.5658 mL 3.1317 mL
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