Schizandrin B
(Synonyms: 五味子乙素; γ-Schisandrin; Wuweizisu B) 目录号 : GN10132
A dibenzocyclooctadiene with diverse biological activities
Cas No.:61281-37-6
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
IC50: N/A
Schisandrin B (Sch B), the most abundant dibenzocyclooctadiene lignin, is isolated from the fruit of Schisandra chinensis.
In vitro: Schisandrin B has early been found to inhibit in vitro lipid peroxidation by NADPH/ ascorbate and cysteine/ferric systems in isolated rat liver microsomes. In addition, using electron spin resonance measurement, Sch B was shown to scavenge both in vitro hydroxyl and superoxide radicals. In contrast to that α-tocopherol produced prooxidant and antioxidant effect on Fe3+-induced lipid peroxidation, Sch B could only inhibit the peroxidation reaction [1].
In vivo: Five days after a single injection of doxorubicin (Dox) administration (20 mg/kg IP), left ventricular (LV) performance in mice was depressed significantly and was improved by Sch B treatment. Sch B could prevent the Dox-induced lipid peroxidation increase, nitrotyrosine formation, as well as metalloproteinase activation in the heart. Additionally, the increased expression of phosphop38 MAPK and phospho-MAPK activated mitogen kinase 2 levels by Dox were found to be suppressed by Sch B treatment significantly. Moreover, Sch B also attenuated Dox-induced higher expression of LV proinflammatory cytokines, myocardial apoptosis, cardiomyocyte DNA damage, caspase-3 positive cells and phopho-p53 levels in mice [2].
Clinical trial: N/A
References:
[1] Mak DH,Ip SP,Li PC,Poon MK,Ko KM. Effects of Schisandrin B and alpha-tocopherol on lipid peroxidation, in vitro and in vivo. Mol Cell Biochem.1996 Dec 20;165(2):161-5.
[2] Thandavarayan RA,Giridharan VV,Arumugam S,Suzuki K,Ko KM,Krishnamurthy P,Watanabe K,Konishi T. Schisandrin B prevents doxorubicin induced cardiac dysfunction by modulation of DNA damage, oxidative stress and inflammation through inhibition of MAPK/p53 signaling. PLoS One.2015 Mar 5;10(3):e0119214.
| Cas No. | 61281-37-6 | SDF | |
| 别名 | 五味子乙素; γ-Schisandrin; Wuweizisu B | ||
| 化学名 | 1,2,3,13-tetramethoxy-6,7-dimethyl-5,6,7,8-tetrahydrobenzo[3',4']cycloocta[1',2':4,5]benzo[1,2-d][1,3]dioxole | ||
| Canonical SMILES | [H]C(C([H])([H])C(C1=C2OC([H])([H])[H])=C([H])C3=C2OC([H])([H])O3)(C([H])([H])[H])C(C([H])([H])[H])([H])C([H])([H])C(C1=C4OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C4OC([H])([H])[H] | ||
| 分子式 | C23H28O6 | 分子量 | 400.46 |
| 溶解度 | ≥ 20mg/mL in DMSO | 储存条件 | Store at 2-8°C, protect from light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
||
| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 2.4971 mL | 12.4856 mL | 24.9713 mL |
| 5 mM | 0.4994 mL | 2.4971 mL | 4.9943 mL |
| 10 mM | 0.2497 mL | 1.2486 mL | 2.4971 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet