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SD 1029 Sale

(Synonyms: JAK2 Inhibitor III, Janus-Associated Kinase 2 Inhibitor III) 目录号 : GC44880

A JAK2 inhibitor

SD 1029 Chemical Structure

Cas No.:118372-34-2

规格 价格 库存 购买数量
1mg
¥428.00
现货
5mg
¥1,936.00
现货

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Sample solution is provided at 25 µL, 10mM.

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Quality Control & SDS

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Chemical Properties

Cas No. 118372-34-2 SDF
别名 JAK2 Inhibitor III, Janus-Associated Kinase 2 Inhibitor III
Canonical SMILES ClC1=C(Cl)C=CC(C2C3=C(CCC(CN(C)C)C3=O)OC4=C2C(C(CN(C)C)CC4)=O)=C1.Br.Br
分子式 C25H30Cl2N2O3•2HBr 分子量 639.3
溶解度 DMSO: 10 mg/ml 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

制备储备液
1 mg 5 mg 10 mg
1 mM 1.5642 mL 7.8211 mL 15.6421 mL
5 mM 0.3128 mL 1.5642 mL 3.1284 mL
10 mM 0.1564 mL 0.7821 mL 1.5642 mL
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Research Update

Pre-stroke seizures: A nationwide register-based investigation

Seizure 2017 Jul;49:25-29.PMID:28544888DOI:10.1016/j.seizure.2017.05.010.

Purpose: The relationship between cerebrovascular disease and seizures is clearly illustrated by poststroke epilepsy. Seizures can also be the first manifestation of cerebrovascular disease and case-control studies have demonstrated that seizures carry an increased risk of subsequent stroke. Thus, seizures could serve as a marker for vascular risk that merits intervention, but more data is needed before proper trials can be conducted. The occurrence of pre-stroke seizures has not been assessed on a national scale. We asked what proportion of strokes in middle-aged and elderly patients was preceded by seizures. Methods: All patients over 60 years of age with first-ever stroke in 2005-2010 (n=92,596) were identified in the Swedish stroke register (Riksstroke) and cross-sectional data on a history of a first seizure or epilepsy diagnosis in the ten years preceding stroke were collected from national patient registers with mandatory reporting. Results: 1372 patients (1.48%) had a first seizure or epilepsy diagnosis registered less than ten years prior to the index stroke. The mean latency between seizure and stroke was 1474days (SD 1029 days). Conclusions: Seizures or epilepsy preceded 1.48% of strokes in patients >60years of age. Based on recent national incidence figures, 5-20% of incident cases of seizures or epilepsy after 60 years of age could herald stroke, depending on age group. These proportions are of a magnitude that merit further study on how to reduce the risk of stroke in patients with late-onset seizures or epilepsy.