Secoisolariciresinol diglucoside (SDG)
(Synonyms: (R,R)-亚麻木酚素; (R,R)-SDG; (R,R)-LGM2605) 目录号 : GC34020
A lignan with diverse biological activities
Cas No.:158932-33-3
Sample solution is provided at 25 µL, 10mM.
Secoisolariciresinol diglucoside (SDG) is a lignan that has been found in flaxseed with antioxidant, antiproliferative, antidiabetic, and cardioprotective biological activities.1,2,3,4,5,6 It scavenges 2,2-diphenyl-1-picrylhydrazyl radicals (IC50 = 78.9 μg/ml) in a cell-free assay and dose-dependently inhibits the growth of SW480 human colon cancer cells in vitro.2,3 Dietary administration of SDG reduces the number of proliferating tumor cells in an MCF-7 human breast cancer mouse xenograft model in the presence of circulating estrogen.4 It also increases insulin and decreases glucose serum levels in rats with diabetes induced by streptozotocin when administered at a dose of 20 mg/kg.5 SDG (20 mg/kg per day) decreases infarct size in rats with myocardial infarction induced by permanent occlusion of the left anterior descending coronary artery.6
1.Imran, M., Ahmad, N., Anjum, F.M., et al.Potential protective properties of flax lignan secoisolariciresinol diglucosideNutr. J.14:71(2015) 2.Moree, S.S., and Rajesha, J.Investigation of in vitro and in vivo antioxidant potential of secoisolariciresinol diglucosideMol. Cell Biochem.373(1-2)179-187(2013) 3.Ayella, A., Lim, S., Jiang, Y., et al.Cytostatic inhibition of cancer cell growth by lignan secoisolariciresinol diglucosideNutr. Res.30(11)762-769(2010) 4.Truan, J.S., Chen, J.-M., and Thompson, L.U.Comparative effects of sesame seed lignan and flaxseed lignan in reducing the growth of human breast tumors (MCF-7) at high levels of circulating estrogen in athymic miceNutr. Cancer64(1)65-71(2012) 5.Moree, S.S., Kavishankar, G.B., and Rajesha, J.Antidiabetic effect of secoisolariciresinol diglucoside in streptozotocin-induced diabetic ratsPhytomedicine20(3-4)237-245(2013) 6.Penumathsa, S.V., Koneru, S., Zhan, L., et al.Secoisolariciresinol diglucoside induces neovascularization-mediated cardioprotection against ischemia-reperfusion injury in hypercholesterolemic myocardiumJ. Mol. Cell. Cardiol.44(1)170-179(2008)
| Cas No. | 158932-33-3 | SDF | |
| 别名 | (R,R)-亚麻木酚素; (R,R)-SDG; (R,R)-LGM2605 | ||
| Canonical SMILES | COC1=C(O)C=CC(C[C@@H](CO[C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)CO)[C@@](CO[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO)([H])CC4=CC(OC)=C(O)C=C4)=C1 | ||
| 分子式 | C32H46O16 | 分子量 | 686.7 |
| 溶解度 | Water : ≥ 100 mg/mL (145.62 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.4562 mL | 7.2812 mL | 14.5624 mL |
| 5 mM | 0.2912 mL | 1.4562 mL | 2.9125 mL |
| 10 mM | 0.1456 mL | 0.7281 mL | 1.4562 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet