Sermorelin (acetate)
(Synonyms: 易吸潮) 目录号 : GC49592
A growth hormone-releasing hormone analog
Cas No.:516482-86-3
Sample solution is provided at 25 µL, 10mM.
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Sermorelin is a 29-residue N-terminal analog of growth hormone-releasing hormone (GHRH) that retains the ability to stimulate growth hormone (GH) release.1 Sermorelin (1 μg/kg, i.v.) increases serum GH levels in rats by approximately 17% compared with saline control after 15 minutes.2 It also increases GH release in pigs when administered at a dose of 250 ng/kg.3 Sermorelin (1 μM) increases proliferation of NCI-H727 human bronchial carcinoid cells by 30% and increases vascular endothelial growth factor (VEGF) secretion.4 It increases phosphorylation of focal adhesion kinase (FAK) and expression of VEGF in A549 lung cancer cells when used at a concentration of 0.1 μM.5 Formulations containing sermorelin have been used to diagnose and treat growth hormone deficiency.
1.Rivier, J., Spiess, J., Thorner, M., et al.Characterization of a growth hormone-releasing factor from a human pancreatic islet tumourNature300(5889)276-278(1982) 2.Izdebski, J., Pinski, J., Horvath, J.E., et al.Synthesis and biological evaluation of superactive agonists of growth hormone-releasing hormoneProc. Natl. Acad. Sci. USA92(11)4872-4876(1995) 3.Lance, V.A., Murphy, W.A., Sueiras-Diaz, J., et al.Super-active analogs of growth hormone-releasing factor (1-29)-amideBiochem. Bioph. Res. Commun.119(1)265-272(1984) 4.Stepie, T., Sacewicz, M., Lawnicka, H., et al.Stimulatory effect of growth hormone-releasing hormone (GHRH(1-29)NH2) on the proliferation, VEGF and chromogranin A secretion by human neuroendocrine tumor cell line NCI-H727 in vitroNeuropeptides43(5)397-400(2009) 5.Siejka, A., Barabutis, N., and Schally, A.V.GHRH antagonist inhibits focal adhesion kinase (FAK) and decreases expression of vascular endothelial growth factor (VEGF) in human lung cancer cells in vitroPeptides37(1)63-68(2012)
| Cas No. | 516482-86-3 | SDF | Download SDF |
| 别名 | 易吸潮 | ||
| Canonical SMILES | NC([C@H](CCCNC(N)=N)NC([C@H](CO)NC([C@@H](NC([C@@]([C@H](CC)C)([H])NC([C@@H](NC([C@H](CCC(N)=O)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CCC(N)=O)NC(CNC([C@H](CC(C)C)NC([C@H](C(C)C)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CO)NC([C@H](CC(N)=O)NC([C@@]([C@@H](C)O)([H])NC([C@@H](NC([C@@]([C@H](CC)C)([H])NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](N[H])CC1=CC=C(O)C=C1)=O)C)=O)CC(O)=O)=O)C)=O)=O)CC2=CC=CC=C2)=O)=O)=O)=O)CC3=CC=C(O)C=C3)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)CC(O)=O)=O)=O)CCSC)=O)=O)=O.CC(O)=O | ||
| 分子式 | C149H246N44O42S • XC2H4O2 | 分子量 | 3357.9 |
| 溶解度 | Water: 1 mg/ml | 储存条件 | -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 0.2978 mL | 1.489 mL | 2.9781 mL |
| 5 mM | 0.0596 mL | 0.2978 mL | 0.5956 mL |
| 10 mM | 0.0298 mL | 0.1489 mL | 0.2978 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet