Sesamol
(Synonyms: 芝麻酚) 目录号 : GC34177
A lignan with diverse biological activities
Cas No.:533-31-3
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Sesamol is a lignan originally isolated from S. indicum that has diverse biological activities, including antioxidant, antibacterial, anticancer, and anti-obesity properties.1,2,3,4 Sesamol scavenges 2,2-diphenyl-1-picrylhydrazyl radicals with an IC50 value of 5.44 μg/ml and is active against B. cereus and S. aureus (MICs = 2 mg/ml for both).2 It also inhibits the growth of HepG2 human hepatocellular carcinoma cells in a concentration-dependent manner.3 Sesamol (100 mg/kg) reduces weight gain and hepatic steatosis in a mouse model of obesity induced by a high-fat diet (HFD).4
1.Majdalawieh, A.F., and Mansour, Z.R.Sesamol, a major lignan in sesame seeds (Sesamum indicum): Anti-cancer properties and mechanisms of actionEur. J. Pharmacol.85575-89(2019) 2.Kumar, C.M., and Singh, S.A.Bioactive lignans from sesame (Sesamum indicum L.): Evaluation of their antioxidant and antibacterial effects for food applicationsJ. Food Sci. Technol.52(5)2934-2941(2015) 3.Liu, Z., Ren, B., Wang, Y., et al.Sesamol induces human hepatocellular carcinoma cells apoptosis by impairing mitochondrial function and suppressing autophagySci. Rep.75728(2017) 4.Lee, D.H., Chang, S.-H., Yang, D.-K., et al.Sesamol increases Ucp1 expression in white adipose tissues and stimulates energy expenditure in high-fat diet-fed obese miceNutrients12(5)1459(2020)
| Cas No. | 533-31-3 | SDF | |
| 别名 | 芝麻酚 | ||
| Canonical SMILES | OC1=CC=C(OCO2)C2=C1 | ||
| 分子式 | C7H6O3 | 分子量 | 138.12 |
| 溶解度 | DMSO: ≥ 100 mg/mL (724.01 mM); Ethanol: ≥ 100 mg/mL (724.01 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 7.2401 mL | 36.2004 mL | 72.4008 mL |
| 5 mM | 1.448 mL | 7.2401 mL | 14.4802 mL |
| 10 mM | 0.724 mL | 3.62 mL | 7.2401 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Sesamol, a major lignan in sesame seeds (Sesamum indicum): Anti-cancer properties and mechanisms of action
Eur J Pharmacol 2019 Jul 15;855:75-89.PMID:31063773DOI:10.1016/j.ejphar.2019.05.008.
Sesamol is a natural phenolic compound and a major lignan isolated from sesame seeds (Sesamum indicum) and sesame oil. The therapeutic potential of Sesamol was investigated intensively, and there is compelling evidence that Sesamol acts as a metabolic regulator that possesses antioxidant, anti-mutagenic, anti-hepatotoxic, anti-inflammatory, anti-aging, and chemopreventive properties. Various studies have reported that Sesamol exerts potent anti-cancer effects. Herein, we provide a comprehensive review that summarizes the in vitro and in vivo anti-cancer activity of Sesamol in several cancer cell lines and animal models. The protective role that Sesamol plays against oxidative stress through its radical scavenging ability and lipid peroxidation lowering potential is analyzed. The ability of Sesamol to regulate apoptosis and various stages of the cell cycle is also outlined. Moreover, the signaling pathways that Sesamol seems to target to execute its antioxidant, anti-inflammatory, and pro-apoptotic/anti-proliferative roles are discussed. The signaling pathways that Sesamol targets include the p53, MAPK, JNK, PI3K/AKT, TNFα, NF-κB, PPARγ, caspase-3, Nrf2, eNOS, and LOX pathways. The mechanisms of action that Sesamol executes to deliver its anti-cancer effects are delineated. In sum, there is ample evidence suggesting that Sesamol possesses potent anti-cancer properties in vitro and in vivo. A thorough understanding of the molecular targets of Sesamol and the mechanisms of action underlying its anti-cancer effects is necessary for possible employment of Sesamol as a chemotherapeutic agent in cancer prevention and therapy.
Sesamol-Loaded PLGA Nanosuspension for Accelerating Wound Healing in Diabetic Foot Ulcer in Rats
Int J Nanomedicine 2020 Nov 23;15:9265-9282.PMID:33262587DOI:10.2147/IJN.S268941.
Background: Diabetic foot ulcer is an intractable complication of diabetes, characterized by the disturbed inflammatory and proliferative phases of wound healing. Sesamol, a phenolic compound, has been known for its powerful antioxidant, anti-inflammatory, anti-hyperglycaemic and wound healing properties. The aim of the present study was to develop a Sesamol nano formulation and to study its effect on the various phases of the wound healing process in diabetic foot condition. Methods: Sesamol-PLGA (SM-PLGA) nanosuspension was developed using nanoprecipitation method. TEM, in vitro drug release assay and in vivo pharmacokinetic studies were performed for the optimised formulation. Diabetic foot ulcer (DFU) in high fat diet (HFD)-fed streptozotocin-induced type-II diabetic animal model was used to assess the SM-PLGA nanosuspension efficacy. SM-PLGA nanosuspension was administered by oral route. TNF-α levels were estimated using ELISA and Western blot analysis was performed to assess the effect on the expression of HSP-27, ERK, PDGF-B and VEGF in wound tissue. Wound re-epithelization, fibroblast migration, collagen deposition and inflammatory cell infiltration were assessed by H&E and Masson's trichrome staining. Effect on angiogenesis was assessed by CD-31 IHC staining in wound sections. Results: The optimized SM-PLGA nanosuspension had an average particle size of <300 nm, PDI<0.200 with spherical shaped particles. Approximately 80% of the drug was released over a period of 60 h in in vitro assay. Half-life of the formulation was found to be 13.947 ± 0.596 h. SM-PLGA nanosuspension treatment decreased TNF-α levels in wound tissue and accelerated the collagen deposition. Whereas, HSP-27, ERK, PDGF-B and VEGF expression increased and improved new blood vessels' development. Rapid re-epithelization, fibroblast migration, collagen deposition and reduced inflammatory cell infiltration at the wound site were also observed. Conclusion: Results indicate that sesamol-PLGA nanosuspension significantly promotes the acceleration of wound healing in diabetic foot ulcers by restoring the altered wound healing process in diabetic condition.
Sesamol: a powerful functional food ingredient from sesame oil for cardioprotection
Food Funct 2020 Feb 26;11(2):1198-1210.PMID:32037412DOI:10.1039/c9fo01873e.
Phytophenols are important bioactive food based chemical entities, largely present in several natural sources. Among them, Sesamol is one of the key natural phenols found in sesame seeds, Piper cubeba etc. Several studies have reported that sesame oil is a potent cardioprotective functional food. Papers on the utility of Sesamol in sesame oil (the chemical name of Sesamol is methylenedioxyphenol, MDP) have appeared in the literature, though there is no single concise review on the usefulness of Sesamol in sesame oil in CVD in the literature. Cardiovascular disease (CVD) is the most challenging health problem encountered by the global population. There has been increasing interest in the growth of effective cardiovascular therapeutics, specifically of natural origin. Among various natural sources of chemicals, phytochemicals are micronutrients and bio-compatible scaffolds having an extraordinary efficacy at multiple disease targets with minimal or no adverse effect. This review offers a perspective on the existing literature on functional ingredients in sesame oil with particular focus on Sesamol and its derivatives having nutritional and cardioprotective properties. This is demonstrated to have shown a specifically modulating oxidative enzyme myeloperoxidase (MPO) and other proteins which are detrimental to human well-being. The molecular mechanism of cardioprotection by this food ingredient is primarily attributed to the methylenedioxy group present in the Sesamol component.
Sesamol Attenuates Scopolamine-Induced Cholinergic Disorders, Neuroinflammation, and Cognitive Deficits in Mice
J Agric Food Chem 2022 Oct 26;70(42):13602-13614.PMID:36239029DOI:10.1021/acs.jafc.2c04292.
Alzheimer's disease (AD) is a neurodegenerative disease, characterized by memory loss and cognitive deficits accompanied by neuronal damage and cholinergic disorders. Sesamol, a lignan component in sesame oil, has been proven to have neuroprotective effects. This research aimed to investigate the preventive effects of Sesamol on scopolamine (SCOP)-induced cholinergic disorders in C57BL/6 mice. The mice were pretreated with Sesamol (100 mg/kg/d, p.o.) for 30 days. Behavioral tests indicated that Sesamol supplement prevented SCOP-induced cognitive deficits. Sesamol enhanced the expression of neurotrophic factors and postsynaptic density (PSD) in SCOP-treated mice, reversing neuronal damage and synaptic dysfunction. Importantly, Sesamol could balance the cholinergic system by suppressing the AChE activity and increasing the ChAT activity and M1 mAChR expression. Sesamol treatment also inhibited the expression of inflammatory factors and overactivation of microglia in SCOP-treated mice. Meanwhile, Sesamol improved the antioxidant enzyme activity and suppressed oxidative stress in SCOP-treated mice and ameliorated the oxidized cellular status and mitochondrial dysfunction in SCOP-treated SH-SY5Y cells. In conclusion, these results indicated that Sesamol attenuated SCOP-induced cognitive dysfunction via balancing the cholinergic system and reducing neuroinflammation and oxidative stress.
An Appraisal of Current Pharmacological Perspectives of Sesamol: A Review
Mini Rev Med Chem 2020;20(11):988-1000.PMID:32167426DOI:10.2174/1389557520666200313120419.
Sesame (Sesamum indicum L.) seeds have been authenticated for its medicinal value in both Chinese and Indian systems of medicine. Its numerous potential nutritional benefits are attributed to its main bioactive constituents, Sesamol. As a result of those studies, several molecular mechanisms are emerging describing the pleiotropic biological effects of Sesamol. This review summarized the most interesting in vitro and in vivo studies on the biological effects of Sesamol. The present work summarises data available from Pubmed and Scopus database. Several molecular mechanisms have been elucidated describing the pleiotropic biological effects of Sesamol. Its major therapeutic effects have been elicited in managing oxidative and inflammatory conditions, metabolic syndrome and mood disorders. Further, compelling evidence reflected the ability of Sesamol in inhibiting proliferation of the inflammatory cell, prevention of invasion and angiogenesis via affecting multiple molecular targets and downstream mechanisms. Sesamol is a safe, non-toxic chemical that mediates anti-inflammatory effects by down-regulating the transcription of inflammatory markers such as cytokines, redox status, protein kinases, and enzymes that promote inflammation. In addition, Sesamol also induces apoptosis in cancer cells via mitochondrial and receptor-mediated pathways, as well as activation of caspase cascades. In the present review, several pharmacological effects of Sesamol are summarised namely, antioxidant, anti-cancer, neuroprotective, cardioprotective, anti-inflammatory, hypolipidemic, radioprotective, anti-aging, anti-ulcer, anti-dementia, anti-depressant, antiplatelet, anticonvulsant, anti-anxiolytic, wound healing, cosmetic (skin whitening), anti-microbial, matrix metalloproteinase (MMPs) inhibition, hepatoprotective activity and other biological effects. Here we have summarized the proposed mechanism behind these pharmacological effects.