SIBA
(Synonyms: 5ˊ-异丁硫基-5ˊ-脱氧腺苷,5'-Isobutylthioadenosine; 5'-Deoxy-5'-isobutylthioadenosine) 目录号 : GC33442SIBA (5′-Isobutylthio-5′-deoxyadenosine, 5'-Deoxy-5'-isobutylthioadenosine, 5'-Isobutylthioadenosine) is a synthetic analogue of S-adenosylhomocysteine and is a powerful antipro-liferative drug. SIBA is not only an inhibitor of transmethylation but also interferes with polyamine biosynthesis, probably by blocking aminopropyltransferase.
Cas No.:35899-54-8
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
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- Purity: >99.50%
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- SDS (Safety Data Sheet)
- Datasheet
SIBA (5′-Isobutylthio-5′-deoxyadenosine, 5'-Deoxy-5'-isobutylthioadenosine, 5'-Isobutylthioadenosine) is a synthetic analogue of S-adenosylhomocysteine and is a powerful antipro-liferative drug. SIBA is not only an inhibitor of transmethylation but also interferes with polyamine biosynthesis, probably by blocking aminopropyltransferase.
[1] M Carteni-Farina, et al. FEBS Lett. 1979 Aug 15;104(2):266-70. [2] F Lawrence,, et al. Biochem J. 1982 Jun 15;204(3):853-9.
Cas No. | 35899-54-8 | SDF | |
别名 | 5ˊ-异丁硫基-5ˊ-脱氧腺苷,5'-Isobutylthioadenosine; 5'-Deoxy-5'-isobutylthioadenosine | ||
Canonical SMILES | O[C@@H]([C@H]([C@H](N1C=NC2=C1N=CN=C2N)O3)O)[C@H]3CSCC(C)C | ||
分子式 | C14H21N5O3S | 分子量 | 339.41 |
溶解度 | DMSO : ≥ 100 mg/mL (294.63 mM) | 储存条件 | Store at -20°C |
General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。 为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。 |
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Shipping Condition | 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。 |
制备储备液 | |||
1 mg | 5 mg | 10 mg | |
1 mM | 2.9463 mL | 14.7314 mL | 29.4629 mL |
5 mM | 0.5893 mL | 2.9463 mL | 5.8926 mL |
10 mM | 0.2946 mL | 1.4731 mL | 2.9463 mL |
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给药剂量 | mg/kg | 动物平均体重 | g | 每只动物给药体积 | ul | 动物数量 | 只 | |||
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工作液浓度: mg/ml;
DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,
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1. 首先保证母液是澄清的;
2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。
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Proceedings of the 3rd IPLeiria's International Health Congress : Leiria, Portugal. 6-7 May 2016
BMC Health Serv Res 2016 Jul 6;16 Suppl 3(Suppl 3):200.PMID:27409075DOI:10.1186/s12913-016-1423-5.
S1 Health literacy and health education in adolescence Catarina Cardoso Tomás S2 The effect of a walking program on the quality of life and well-being of people with schizophrenia Emanuel Oliveira, D. Sousa, M. Uba-Chupel, G. Furtado, C. Rocha, A. Teixeira, P. Ferreira S3 Diagnosis and innovative treatments - the way to a better medical practice Celeste Alves S4 Simulation-based learning and how it is a high contribution Stefan Gisin S5 Formative research about acceptability, utilization and promotion of a home fortification programme with micronutrient powders (MNP) in the Autonomous Region of Príncipe, São Tomé and Príncipe Elisabete Catarino, Nelma Carvalho, Tiago Coucelo, Luís Bonfim, Carina Silva S6 Safety culture of the patient: a reflexion about the therapeutic approach on the patient with vocal pathology Débora Franco S7 About wine, fortune cookies and patient experience Jesús Alcoba González O1 The psychological impact on the emergency crews after the disaster event on February 20, 2010 Helena G. Jardim, Rita Silva O2 Musculoskeletal disorders in midwives Cristina L. Baixinho, Mª Helena Presado, Mª Fátima Marques, Mário E. 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Amaral, Marina Lourenço, Mª Clara Rocha, Rui Cruz O23 Sexually transmitted diseases in higher education institutions Sandra Antunes, Verónica Mendonça, Isabel Andrade, Nádia Osório, Ana Valado, Armando Caseiro, António Gabriel, Anabela C. Martins, Fernando Mendes O24 Alcohol consumption and suicide ideation in higher education students Lídia Cabral, Manuela Ferreira, Amadeu Gonçalves O25 Quality of life in university students Tatiana D. Luz, Leonardo Luz, Raul Martins O26 Male and female adolescent antisocial behaviour: characterizing vulnerabilities in a Portuguese sample Alice Morgado, Maria L. Vale-Dias O27 Risk factors for mental health in higher education students of health sciences Rui Porta-Nova O28 International classification of functioning disability and health as reflexive reasoning in primary attention in health Tânia C. Fleig, Éboni M. Reuter, Miriam B. Froemming, Sabrina L. Guerreiro, Lisiane L. Carvalho O29 Risk factors and cardiovascular disease in Portalegre Daniel Guedelha, P. Coelho, A. Pereira O30 Health status of the elderly population living in Portalegre historic city centre: A longitudinal study António Calha, Raul Cordeiro O31 Student’s sleep in higher education: sleep quality among students of the IPB Ana Gonçalves, Ana Certo, Ana Galvão, Mª Augusta Mata O32 Trend in mortality from cervical cancer in the metropolitan area of Florianópolis, state of Santa Catarina, Brazil, 2000 to 2013 Aline Welter, Elayne Pereira, Sandra Ribeiro, Marcia Kretzer O33 Adherence to treatment in the elderly in an urban environment in Spain Juan-Fernando Jiménez-Díaz, Carla Jiménez-Rodríguez, Francisco-José Hernández-Martínez, Bienvenida-Del-Carmen Rodríguez-De-Vera, Alexandre Marques-Rodrigues O34 Beira Baixa Blood Pressure Study (Study PABB) Patrícia Coelho, Tiago Bernardes, Alexandre Pereira O35 Trends in cervical cancer mortality statistics in Santa Catarina State, Brazil, by age group and macro-region, from 2000 to 2013 Patrícia Sousa, João G. Filho, Nazare Nazario, Marcia Kretzer O36 Sleep problems among Portuguese adolescents: a public health issue Odete Amaral, António Garrido, Nélio Veiga, Carla Nunes, Ana R. Pedro, Carlos Pereira O37 Association between body fat and health-related quality of life in patients with type 2 diabetes António Almeia, Helder M. Fernandes, Carlos Vasconcelos, Nelson Sousa, Victor M. Reis, M. João Monteiro, Romeu Mendes O38 Therapy adherence and polypharmacy in non-institutionalized elderly from Amares county, Portugal Isabel C. Pinto, Tânia Pires, João Gama O39 Prevalence of surgical site infection in adults at a hospital unit in the North of Portugal Vera Preto, Norberto Silva, Carlos Magalhães, Matilde Martins O40 Frailty phenotype in old age: implications to intervention Mafalda Duarte, Constança Paúl, Ignácio Martín O41 Portuguese women: sexual symptoms in perimenopause Arminda A. Pinheiro O42 Predictive ability of the Perinatal Depression Screening and Prevention Tool – preliminary results of the categorical approach Sandra Xavier, Julieta Azevedo, Elisabete Bento, Cristiana Marques, Mariana Marques, António Macedo, Ana T. Pereira O43 Aging and muscle strength in patients with type 2 diabetes: cross sectional analysis José P. Almeida, António Almeida, Josiane Alves, Nelson Sousa, Francisco Saavedra, Romeu Mendes O44 Accessibility of the elderly in the prevention of hypertension in a family health unit Ana S. Maia, Michelle T. Oliveira, Anderson R. Sousa, Paulo P. Ferreira, Luci S. Lopes, Eujcely C. Santiago O45 Community Health screenings and self-reported chronic diseases Sílvia Monteiro, Ângelo Jesus, Armanda Colaço, António Carvalho, Rita P. Silva, Agostinho Cruz O46 Evaluation of indoor air quality in Kindergartens Ana Ferreira, Catarina Marques, João P. Figueiredo, Susana Paixão O47 Atmospheric exposure to chemical agents under the occupational activity of pathology technicians Ana Ferreira, Carla Lopes, Fernando Moreira, João P. Figueiredo O48 Occupational exposure to air pollutants in night entertainment venues workers Ana Ferreira, Diana Ribeiro, Fernando Moreira, João P. Figueiredo, Susana Paixão O49 Beliefs and attitudes of young people towards breastfeeding Telma Fernandes, Diogo Amado, Jéssica Leal, Marcelo Azevedo, Sónia Ramalho O50 Profiling informal caregivers: surveying needs in the care of the elderly Catarina Mangas, Jaime Ribeiro, Rita Gonçalves O51 Visual health in teenagers Amélia F Nunes, Ana R. Tuna, Carlos R. Martins, Henriqueta D. Forte O52 Amenable mortality and the geographic accessibility to healthcare in Portugal Cláudia Costa, José A. Tenedório, Paula Santana O53 Bacterial contamination of door handles in a São Paulo See Metropolitan Cathedral public restrooms in Brazil J. A. Andrade, J. L. Pinto, C. Campofiorito, S. Nunes, A. Carmo, A. Kaliniczenco, B. Alves, F. Mendes, C. Jesus, F. Fonseca, F. Gehrke O54 Adherence of patients to rehabilitation programmes Carlos Albuquerque, Rita Batista, Madalena Cunha, António Madureira, Olivério Ribeiro, Rosa Martins O55 Prevalence of malnutrition among Portuguese elderly living in nursing homes: preliminary results of the PEN-3S project Teresa Madeira, Catarina Peixoto-Plácido, Nuno Santos, Osvaldo Santos, Astrid Bergland, Asta Bye, Carla Lopes, Violeta Alarcão, Beatriz Goulão, Nuno Mendonça, Paulo Nicola, João G. Clara O56 Relation between emotional intelligence and mental illness in health students João Gomes, Ana Querido, Catarina Tomás, Daniel Carvalho, Marina Cordeiro P1 Fall risk factors in people older than 50 years old – a pilot report Marlene C. Rosa, Alda Marques P2 What about the Portuguese oldest old? 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Fernandes, Cremilde Cabral, Samuel Alves, Pedro Sousa O75 Community Based Mental Health: contributions of an interdisciplinary international program for students in higher health education António Ferreira, Fernanda Príncipe, Ulla-Maija Seppänen, Margarida Ferreira, Maribel Carvalhais, Marilene Silva O76 Study of satisfaction at work of graduates in nursing: 2002-2014 Manuela Ferreira, Joana Silva, Jéssica Neves, Diana Costa, Bruno Santos, Soraia Duarte O77 Health professionals’ attitudes towards breastfeeding Sílvia Marques, Sónia Ramalho, Isabel Mendes O78 Continuity of nursing care to person with type 2 diabetes Clarisse Louro, Eva Menino, Maria Dixe, Sara S. Dias O79 Stigma toward mental illness among future health professionals Marina Cordeiro, Catarina Tomás, Ana Querido, Daniel Carvalho, João Gomes O80 Working with fears and anxieties of medical students in search of a humanized care Frederico C. Valim, Joyce O. Costa, Lúcia G. 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Silva, Rafaela Rosário P40 Coping strategies of college students Luís Pimenta, Diana Carreira, Patrícia Teles, Teresa Barros P41 Emotional intelligence and mental health stigma in health students Catarina Tomás, Ana Querido, Daniel Carvalho, João Gomes, Marina Cordeiro P42 Stigma of mental health assessment: Comparison between health courses Daniel Carvalho, Ana Querido, Catarina Tomás, João Gomes, Marina Cordeiro O81 Short- and long-term effects of pulmonary rehabilitation in mild COPD Cristina Jácome, Alda Marques O82 Phonological awareness programme for preschool children Sylvie Capelas, Andreia Hall, Dina Alves, Marisa Lousada O83 REforma ATIVA: An efficient health promotion program to be implemented during retirement Mª Helena Loureiro, Ana Camarneiro, Margarida Silva, Aida Mendes, Ana Pedreiro O84 Intervention for men who batter women, a case report Anne G.Silva, Elza S. Coelho O85 Immediate effects of Bowen Therapy on muscle tone and flexibility Flávio Melo, Fernando Ribeiro, Rui Torres, Rui Costa O86 Predictive equation for incremental shuttle walk test in adolescents Tânia Pinho, Cristina Jácome, Alda Marques O87 Life satisfaction and psychopathology in institutionalized elderly people: The results of an adapted Mindfulness-Based Stress Reduction program Bárbara Cruz, Daniel Seabra, Diogo Carreira, Maria Ventura O88 Outcome changes in COPD rehabilitation: exploring the relationship between physical activity and health-related outcomes Joana Cruz, Dina Brooks, Alda Marques O89 Assessing the effectiveness of a Complex Nursing Intervention M Rosário Pinto, Pedro Parreira, Marta Lima-Basto, Miguel Neves, Lisete M. Mónico O90 Psychotherapeutic intervention in addiction disorders: Change in psychopathological symptoms and emotional states Carla Bizarro, Marina Cunha, Ana Galhardo, Couto Margarida, Ana P. Amorim, Eduardo Silva O91 Economic impact of a nursing intervention program to promote self-management in COPD Susana Cruz, José M. Padilha, Jorge Valente O92 Multimodal acute pain management during uterine artery embolization in treatment of uterine myomas José T. Guerrero, Francisco P. Caballero, Rafael B. Santos, Estefania P. Gonzalez, Fátima M. Monago, Lierni U. Ugalde, Marta M. Vélez, Maria J. Tena O93 Fluid administration strategies in major surgery: Goal-directed therapy José T. Guerrero, Rafael Bravo, Francisco L. Pérez-Caballero, Isabel A. Becerra, Mª Elizabeth Agudelo, Guadalupe Acedo, Roberto Bajo O94 Development and implementation of a self-management educational programme using lay-led’s in adolescents Spina Bifida: A pilot study Isabel Malheiro, Filomena Gaspar, Luísa Barros O95 Influence of chair-based yoga exercises on salivary anti-microbial proteins in institutionalized frail-elderly women: a preliminary study Guilherme Furtado, Mateus Uba-Chupel, Mariana Marques, Luís Rama, Margarida Braga, José P. Ferreira, Ana Mª Teixeira O96 High intensity interval training vs moderate intensity continuous training impact on diabetes 2 João Cruz, Tiago Barbosa, Ângela Simões, Luís Coelho O97 Family caregiver of people with pressure ulcer: Nursing intervention plan Alexandre Rodrigues, Juan-Fernando Jiménez-Díaz, Francisco Martinez-Hernández, Bienvenida Rodriguez-De-Vera, Pedro Ferreira, Alexandrina Rodrigues O98 Chronic effects of exercise on motor memory consolidation in elderly people André Ramalho, João Petrica, Pedro Mendes, João Serrano, Inês Santo, António Rosado O99 Impression cytology of the ocular surface: Collection technique and sample processing Paula Mendonça, Kátia Freitas O100 Does sport practice affect the reaction time in neuromuscular activity? Dora Ferreira, António Brito, Renato Fernandes O101 Efficiency of the enteral administration of fibbers in the treatment of chronic obstipation Sofia Gomes, Fernando Moreira, Cláudia Pinho, Rita Oliveira, Ana I. Oliveira O102 Fast decalcifier in compact bone and spongy bone Paula Mendonça, Ana P. Casimiro, Patrícia Martins, Iryna Silva O103 Health promotion in the elderly – Intervention project in dementia Diana Evangelista O104 Prevention of musculoskeletal disorders through an exercise protocol held in labour context Catarina Leitão, Fábia Velosa, Nélio Carecho, Luís Coelho O105 Knowledge of teachers and other education agents on diabetes type 1: Effectiveness of an intervention program Eva Menino, Anjos Dixe, Helena Catarino, Fátima Soares, Ester Gama, Clementina Gordo O106 Treatment of diabetic peripheral neuropathic pain: a systematic review of clinical trials of phase II and III Eliana Moreira, Cristiana Midões, Marlene Santos O107 New drugs for osteoporosis treatment: Systematic review of clinical trials of phase II and III Sara Machado, Vânia P. Oliveira, Marlene Santos O108 Promoting hope at the end of life: Effectiveness of an Intervention Programme Ana Querido, Anjos Dixe, Rita Marques, Zaida Charepe P43 Psychomotor therapy effects on adaptive behaviour and motor proficiency of adults with intellectual disability Ana Antunes, Sofia Santos P44 The effect of exercise therapy in multiple sclerosis – a single study case Marlene C. Rosa P45 Physical condition and self-efficacy in people with fall risk – a preliminary study Marlene C. Rosa, Silvana F. Marques P46 Shock waves: their effectiveness in improving the symptoms of calcifying tendinitis of the shoulder Beatriz Minghelli, Eulália Caro P47 Pacifier – construction and pilot application of a parenting intervention for parents of babies until six months in primary health care Mª José Luís, Teresa Brandão P48 The influence of Motor Imagery in fine motor skills of individuals with disabilities Pedro Mendes, Daniel Marinho, João Petrica, Diogo Monteiro, Rui Paulo, João Serrano, Inês Santo P49 Evaluation of the effects of a walking programme on the fall risk factors in older people – a longitudinal pilot study Lina Monteiro, Fátima Ramalho, Rita Santos-Rocha, Sónia Morgado, Teresa Bento P50 Nursing intervention programme in lifestyles of adolescents Gilberta Sousa, Otília Freitas, Isabel Silva, Gregório Freitas, Clementina Morna, Rita Vasconcelos P51 The person submitted to hip replacement rehabilitation, at home Tatiana Azevedo, Salete Soares, Jacinta Pisco P52 Effects of Melatonin use in the treatment of neurovegetative diseases Paulo P. Ferreira, Efrain O. Olszewer, Michelle T. Oliveira, Anderson R. Sousa, Ana S. Maia, Sebastião T. Oliveira P53 Review of Phytotherapy and other natural substances in alcohol abuse and alcoholism Erica Santos, Ana I. Oliveira, Carla Maia, Fernando Moreira, Joana Santos, Maria F. Mendes, Rita F. Oliveira, Cláudia Pinho P54 Dietary programme impact on biochemical markers in diabetics: systematic review Eduarda Barreira, Ana Pereira, Josiana A. Vaz, André Novo P55 Biological approaches to knee osteoarthritis: platelet-rich plasma and hyaluronic acid Luís D. Silva, Bruno Maia, Eduardo Ferreira, Filipa Pires, Renato Andrade, Luís Camarinha P56 Platelet-rich plasma and hyaluronic acid intra-articular injections for the treatment of ankle osteoarthritis Luís D. Silva, Bruno Maia, Eduardo Ferreira, Filipa Pires, Renato Andrade, Luís Camarinha P57 The impact of preventive measures in the incidence of diabetic foot ulcers: a systematic review Ana F. César, Mariana Poço, David Ventura, Raquel Loura, Pedro Gomes, Catarina Gomes, Cláudia Silva, Elsa Melo, João Lindo P58 Dating violence among young adolescents Joana Domingos, Zaida Mendes, Susana Poeta, Tiago Carvalho, Catarina Tomás, Helena Catarino, Mª Anjos Dixe P59 Physical activity and motor memory in pedal dexterity André Ramalho, António Rosado, Pedro Mendes, Rui Paulo, Inês Garcia, João Petrica P60 The effects of whole body vibration on the electromyographic activity of thigh muscles Sandra Rodrigues, Rui Meneses, Carlos Afonso, Luís Faria, Adérito Seixas P61 Mental health promotion in the workplace Marina Cordeiro, Paulo Granjo, José C. Gomes P62 Influence of physical exercise on the self-perception of body image in elderly women: A systematic review of qualitative studies Nelba R. Souza, Guilherme E. Furtado, Saulo V. Rocha, Paula Silva, Joana Carvalho O109 Psychometric properties of the Portuguese version of the Éxamen Geronto-Psychomoteur (P-EGP) Marina Ana Morais, Sofia Santos, Paula Lebre, Ana Antunes O110 Symptoms of depression in the elderly population of Portugal, Spain and Italy António Calha O111 Emotion regulation strategies and psychopathology symptoms: A comparison between adolescents with and without deliberate self-harm Ana Xavier, Marina Cunha, José Pinto-Gouveia O112 Prevalence of physical disability in people with leprosy Liana Alencar, Madalena Cunha, António Madureira O113 Quality of life and self-esteem in type 1 and type 2 diabetes mellitus patients Ilda Cardoso, Ana Galhardo, Fernanda Daniel, Vítor Rodrigues O114 Cross-cultural comparison of gross motor coordination in children from Brazil and Portugal Leonardo Luz, Tatiana Luz, Maurício R. Ramos, Dayse C. Medeiros, Bruno M. Carmo, André Seabra, Cristina Padez, Manuel C. Silva O115 Electrocardiographic differences between African and Caucasian people António Rodrigues, Patrícia Coelho, Alexandre Coelho O116 Factors associated with domestic, sexual and other types of violence in the city of Palhoça - Brazil Madson Caminha, Filipe Matheus, Elenice Mendes, Jony Correia, Marcia Kretzer O117 Tinnitus prevalence study of users of a hospital of public management - Spain Francisco J. Hernandez-Martinez, Juan F. Jimenez-Diaz, Bienvendida C. Rodriguez-De-Vera, Carla Jimenez-Rodriguez, Yadira Armas-Gonzalez O118 Difficulties experienced by parents of children with diabetes mellitus of preschool age in therapeutic and nutritional management Cátia Rodrigues, Rosa Pedroso O119 E-mental health - “nice to have” or “must have”? Exploring the attitudes towards e-mental health in the general population Jennifer Apolinário-Hagen, Viktor Vehreschild O120 Violence against children and adolescents and the role of health professionals: Knowing how to identify and care Milene Veloso, Celina Magalhães, Isabel Cabral, Maira Ferraz O121 Marital violence. A study in the Algarve population Filipe Nave, Emília Costa, Filomena Matos, José Pacheco O122 Clinical factors and adherence to treatment in ischemic heart disease António Dias, Carlos Pereira, João Duarte, Madalena Cunha, Daniel Silva O123 Can religiosity improve optimism in participants in states of illness, when controlling for life satisfaction? Lisete M. Mónico, Valentim R. Alferes, Mª São João Brêda, Carla Carvalho, Pedro M. Parreira O124 Empowerment, knowledge and quality of life of people with diabetes type 2 in the Alto Minho Health Local Unit Mª Carminda Morais, Pedro Ferreira, Rui Pimenta, José Boavida O125 Antihypertensive therapy adherence among hypertensive patients from Bragança county, Portugal Isabel C. Pinto, Tânia Pires, Catarina Silva O126 Subjective perception of sexual achievement - An exploratory study on people with overweight Maria Ribeiro, Maria Viega-Branco, Filom