Sinapinic acid (Sinapic acid)
(Synonyms: 芥子酸; Sinapic acid) 目录号 : GC31511
A phenylpropanoid hydroxycinnamic acid with diverse biological activities
Cas No.:530-59-6
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Sinapic acid is a phenylpropanoid hydroxycinnamic acid with diverse biological activities.1 Sinapic acid inhibits collagen-induced human platelet aggregation by up to 70% in vitro (IC50 = 1.03 mM).2 It scavenges 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS) free radicals with IC50 values of 8.3 and 5.4 μg/ml, respectively.3 Sinapic acid (200 μM) reduces colony formation of SW480 human colon carcinoma cells by 4-fold.4 It also inhibits colony formation of E. coli, S. enteritidis, and S. aureus on agar (MICs = 2.2, 2, and 1.8 mM, respectively).5 In vivo, sinapic acid (4 mg/kg, p.o.) increases the time spent in the open arms of the elevated plus maze by approximately 15% in mice, an effect that can be blocked by the GABAA receptor antagonists flumazenil and bicuculline .1 Sinapic acid is also commonly used as a matrix in protein mass spectrometry.6
1.Yoon, B.H., Jung, J.W., Lee, J.J., et al.Anxiolytic-like effects of sinapic acid in miceLife Sci.81(3)234-240(2007) 2.Kim, M.-S., Shin, W.-C., Kang, D.-K., et al.Anti-thrombosis activity of sinapic acid isolated from the lees of bokbunja wineJ. Microbiol. Biotechnol.26(1)61-65(2016) 3.Lee, K.J., Oh, Y.C., Cho, W.K., et al.Antioxidant and anti-inflammatory activity determination of one hundred kinds of pure chemical compounds using offline and online screening HPLC assayEvid. Based Complement. Alternat. Med.165457(2015) 4.Hudson, E.A., Dinh, P.A., Kokubun, T., et al.Characterization of potentially chemopreventive phenols in extracts of brown rice that inhibit the growth of human breast and colon cancer cellsCancer Epidemiol. Biomarkers Prev.9(11)1163-1170(2000) 5.Tesaki, S., Tanabe, S., Ono, H., et al.4-Hydroxy-3-nitrophenylacetic and sinapic acids as antibacterial compounds from mustard seedsBiosci. Biotechnol. Biochem.62(5)998-1000(1998) 6.Jonsson, A.P.Mass spectrometry for protein and peptide characterisationCell. Mol. Life Sci.58(7)868-884(2001)
| Cas No. | 530-59-6 | SDF | |
| 别名 | 芥子酸; Sinapic acid | ||
| Canonical SMILES | COC1=C(O)C(OC)=CC(/C=C/C(O)=O)=C1 | ||
| 分子式 | C11H12O5 | 分子量 | 224.21 |
| 溶解度 | DMSO: 100 mg/mL (446.01 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
||
| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 4.4601 mL | 22.3005 mL | 44.601 mL |
| 5 mM | 0.892 mL | 4.4601 mL | 8.9202 mL |
| 10 mM | 0.446 mL | 2.2301 mL | 4.4601 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet