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Sinensetin Sale

(Synonyms: 5,6,7,3',4'-五甲氧基黄酮,Pedalitin permethyl ether) 目录号 : GN10280

An anti-inflammatory flavone

Sinensetin Chemical Structure

Cas No.:2306-27-6

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20mg
¥1,565.00
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产品描述

Sinensetin is a selective inhibitor of α-glucosidase with IC50 value of 0.66 mg/ml [1].
Sinensetin is a family of the major polymethoxyflavones (PMFs) that mainly contained in the citrus peels. It has been reported that sinensetin has various bioactivities, including antifungal, antimutagenic, anticancer, and anti-inflammatory [2] [3].
When tested with human cytochrome P450 1A2 (CYP1A2), sinensetin treatment significantly inhibited the activity of CYP1A2 [4]. Using a method modified by Apostolidis, incubation of sinensetin solution and phosphate buffer (pH 6.9) containing α-glucosidase solution in 96-well plates at 25°C for 10 min markedly inhibitedα-glucosidase [1]. In Human umbilical vein endothelial cells, administration of sinensetin inhibited cell proliferation via inducing cell cycle arrest in the G0/G1 phase which means it has antiangiogenesis activity with low toxicity [2]. When tested with RAW 264.7 cells, sinensetin inhibited inflammatory activity through regulating κB-α expression in protein level [3]. Treated human AGS gastric cancer cells with sinensetin showed that it increased p53 and p21 expression and resulted in the inhibited proliferation and apoptosis [5].
In animal model of zebrafish, sinensetin treatment downregulated the expression of flt1, kdrl, and hras that associated with angiogenesis in mRNA level [2].
References:
[1].    Mohamed, E.A., et al., Potent alpha-glucosidase and alpha-amylase inhibitory activities of standardized 50% ethanolic extracts and sinensetin from Orthosiphon stamineus Benth as anti-diabetic mechanism. BMC Complement Altern Med, 2012. 12: p. 176.
[2].    Lam, I.K., et al., In vitro and in vivo structure and activity relationship analysis of polymethoxylated flavonoids: identifying sinensetin as a novel antiangiogenesis agent. Mol Nutr Food Res, 2012. 56(6): p. 945-56.
[3].    Shin, H.S., et al., Sinensetin attenuates LPS-induced inflammation by regulating the protein level of IkappaB-alpha. Biosci Biotechnol Biochem, 2012. 76(4): p. 847-9.
[4].    Pan, Y., et al., In vitro effect of important herbal active constituents on human cytochrome P450 1A2 (CYP1A2) activity. Phytomedicine, 2014. 21(12): p. 1645-50.
[5].    Dong, Y., et al., [Effects of sinensetin on proliferation and apoptosis of human gastric cancer AGS cells]. Zhongguo Zhong Yao Za Zhi, 2011. 36(6): p. 790-4.

Chemical Properties

Cas No. 2306-27-6 SDF
别名 5,6,7,3',4'-五甲氧基黄酮,Pedalitin permethyl ether
化学名 2-(3,4-dimethoxyphenyl)-5,6,7-trimethoxychromen-4-one
Canonical SMILES COC1=C(C=C(C=C1)C2=CC(=O)C3=C(C(=C(C=C3O2)OC)OC)OC)OC
分子式 C20H20O7 分子量 372.37
溶解度 DMF: 0.5 mg/mL 储存条件 Store at 2-8°C
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1 mg 5 mg 10 mg
1 mM 2.6855 mL 13.4275 mL 26.855 mL
5 mM 0.5371 mL 2.6855 mL 5.371 mL
10 mM 0.2686 mL 1.3428 mL 2.6855 mL
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